Spike-timing-dependent plasticity can account for connectivity aftereffects of dual-site transcranial alternating current stimulation
Transcranial alternating current stimulation (tACS), applied to two brain sites with different phase lags, has been shown to modulate stimulation-outlasting functional EEG connectivity between the targeted regions. Given the lack of knowledge on mechanisms of tACS aftereffects, it is difficult to fu...
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| Format: | Article |
| Language: | English |
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Elsevier
2021-08-01
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| Series: | NeuroImage |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1053811921004560 |
| _version_ | 1818655167789137920 |
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| author | Bettina C. Schwab Peter König Andreas K. Engel |
| author_facet | Bettina C. Schwab Peter König Andreas K. Engel |
| author_sort | Bettina C. Schwab |
| collection | DOAJ |
| description | Transcranial alternating current stimulation (tACS), applied to two brain sites with different phase lags, has been shown to modulate stimulation-outlasting functional EEG connectivity between the targeted regions. Given the lack of knowledge on mechanisms of tACS aftereffects, it is difficult to further enhance effect sizes and reduce variability in experiments. In this computational study, we tested if spike-timing-dependent plasticity (STDP) can explain stimulation-outlasting connectivity modulation by dual-site tACS and explored the effects of tACS parameter choices. Two populations of spiking neurons were coupled with synapses subject to STDP, and results were validated via a re-analysis of EEG data. Our simulations showed stimulation-outlasting connectivity changes between in- and anti-phase tACS, dependent on both tACS frequency and synaptic conduction delays. Importantly, both a simple network entraining to a wide range of tACS frequencies as well as a more realistic network that spontaneously oscillated at alpha frequency predicted that the largest effects would occur for short conduction delays between the stimulated regions. This finding agreed with experimental EEG connectivity modulation by 10Hz tACS, showing a clear negative correlation of tACS effects with estimated conduction delays between regions. In conclusion, STDP can explain connectivity aftereffects of dual-site tACS. However, not all combinations of tACS frequency and application sites are expected to effectively modulate connectivity via STDP. We therefore suggest using appropriate computational models and/or EEG analysis for planning and interpretation of dual-site tACS studies relying on aftereffects. |
| first_indexed | 2024-12-17T03:05:23Z |
| format | Article |
| id | doaj.art-194ef51c10fb419286c8ff95b99e6140 |
| institution | Directory Open Access Journal |
| issn | 1095-9572 |
| language | English |
| last_indexed | 2024-12-17T03:05:23Z |
| publishDate | 2021-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage |
| spelling | doaj.art-194ef51c10fb419286c8ff95b99e61402022-12-21T22:05:58ZengElsevierNeuroImage1095-95722021-08-01237118179Spike-timing-dependent plasticity can account for connectivity aftereffects of dual-site transcranial alternating current stimulationBettina C. Schwab0Peter König1Andreas K. Engel2Corresponding author at:. Department of Neurophysiology and Pathophysiology, University Medical Center Hamburg-Eppendorf Martinistraße 52, 20246 Hamburg, Germany.; Department of Neurophysiology and Pathophysiology, University Medical Center Hamburg-Eppendorf, Germany; Berlin Institute for Advanced Study, GermanyDepartment of Neurophysiology and Pathophysiology, University Medical Center Hamburg-Eppendorf, Germany; Institute of Cognitive Science, University of Osnabrück, GermanyDepartment of Neurophysiology and Pathophysiology, University Medical Center Hamburg-Eppendorf, GermanyTranscranial alternating current stimulation (tACS), applied to two brain sites with different phase lags, has been shown to modulate stimulation-outlasting functional EEG connectivity between the targeted regions. Given the lack of knowledge on mechanisms of tACS aftereffects, it is difficult to further enhance effect sizes and reduce variability in experiments. In this computational study, we tested if spike-timing-dependent plasticity (STDP) can explain stimulation-outlasting connectivity modulation by dual-site tACS and explored the effects of tACS parameter choices. Two populations of spiking neurons were coupled with synapses subject to STDP, and results were validated via a re-analysis of EEG data. Our simulations showed stimulation-outlasting connectivity changes between in- and anti-phase tACS, dependent on both tACS frequency and synaptic conduction delays. Importantly, both a simple network entraining to a wide range of tACS frequencies as well as a more realistic network that spontaneously oscillated at alpha frequency predicted that the largest effects would occur for short conduction delays between the stimulated regions. This finding agreed with experimental EEG connectivity modulation by 10Hz tACS, showing a clear negative correlation of tACS effects with estimated conduction delays between regions. In conclusion, STDP can explain connectivity aftereffects of dual-site tACS. However, not all combinations of tACS frequency and application sites are expected to effectively modulate connectivity via STDP. We therefore suggest using appropriate computational models and/or EEG analysis for planning and interpretation of dual-site tACS studies relying on aftereffects.http://www.sciencedirect.com/science/article/pii/S1053811921004560Transcranial alternating current stimulationSpike-timing-dependent plasticityElectroencephalogramFunctional connectivityEntrainment |
| spellingShingle | Bettina C. Schwab Peter König Andreas K. Engel Spike-timing-dependent plasticity can account for connectivity aftereffects of dual-site transcranial alternating current stimulation NeuroImage Transcranial alternating current stimulation Spike-timing-dependent plasticity Electroencephalogram Functional connectivity Entrainment |
| title | Spike-timing-dependent plasticity can account for connectivity aftereffects of dual-site transcranial alternating current stimulation |
| title_full | Spike-timing-dependent plasticity can account for connectivity aftereffects of dual-site transcranial alternating current stimulation |
| title_fullStr | Spike-timing-dependent plasticity can account for connectivity aftereffects of dual-site transcranial alternating current stimulation |
| title_full_unstemmed | Spike-timing-dependent plasticity can account for connectivity aftereffects of dual-site transcranial alternating current stimulation |
| title_short | Spike-timing-dependent plasticity can account for connectivity aftereffects of dual-site transcranial alternating current stimulation |
| title_sort | spike timing dependent plasticity can account for connectivity aftereffects of dual site transcranial alternating current stimulation |
| topic | Transcranial alternating current stimulation Spike-timing-dependent plasticity Electroencephalogram Functional connectivity Entrainment |
| url | http://www.sciencedirect.com/science/article/pii/S1053811921004560 |
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