Influence of Intratumor Heterogeneity on the Predictivity of MGMT Gene Promoter Methylation Status in Glioblastoma

Influence of Intratumor Heterogeneity on the Predictivity of MGMT Gene Promoter Methylation Status in Glioblastoma

Glioblastoma is the most aggressive tumor of the central nervous system. Prognosis is poor, even in the presence of a methylated state of MGMT gene promoter, which represents the biomarker with the highest prognostic/predictive value for the standard treatment of patients. Among patients with a meth...

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Bibliographic Details
Main Authors: Giovanni Brigliadori, Giulia Goffredo, Daniela Bartolini, Luigino Tosatto, Lorena Gurrieri, Laura Mercatali, Toni Ibrahim
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-10-01
Series:Frontiers in Oncology
Subjects:
temozolamide
MGMT methylation
intratumor heterogeneity
predictivity
glioblastoma
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2020.533000/full

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