Several Alkaloids Derived from Plants and Their Underlying Molecular Mechanisms of Action in the Fight Against Cancer
Multidrug resistance is one of the major obstacles to successful cancer chemotherapy, which causes cancer to remain one of the leading causes of death worldwide. Therefore, the use of natural products for cancer prevention and therapy has been continuously investigated and developed for decades. Alk...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Prince of Songkla University
2017-01-01
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| Series: | Journal of Health Science and Medical Research (JHSMR) |
| Subjects: | |
| Online Access: | https://www.jhsmr.org/index.php/jhsmr/article/view/135 |
| _version_ | 1818872957350445056 |
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| author | Siribhorn Madla Potchanapond Graidist |
| author_facet | Siribhorn Madla Potchanapond Graidist |
| author_sort | Siribhorn Madla |
| collection | DOAJ |
| description | Multidrug resistance is one of the major obstacles to successful cancer chemotherapy, which causes cancer to remain one of the leading causes of death worldwide. Therefore, the use of natural products for cancer prevention and therapy has been continuously investigated and developed for decades. Alkaloids are one of the important compounds derived from natural products that have been extensively studied for their potential use as cancer chemopreventive and chemotherapeutic drugs in both in vitro and animal studies. This short review intends to present the molecular mechanisms of action of alkaloids on stimulation and inhibition some signaling molecules involved in cell proliferation, differentiation, angiogenesis, metastasis and apoptosis pathways of cancer cells. The understanding of the molecular mechanisms of alkaloids against cancer will provide clues towards a diagnostic, prevention and therapeutic applications. Based on the information provided in this article, alkaloids show remarkable potential as anticancer agents. However, more research and clinical trials are crucial before applying any of these alkaloids as new medicine to treat cancer patients. |
| first_indexed | 2024-12-19T12:47:04Z |
| format | Article |
| id | doaj.art-194fdcf68b1a4836827d8ca63affa89e |
| institution | Directory Open Access Journal |
| issn | 2586-9981 2630-0559 |
| language | English |
| last_indexed | 2024-12-19T12:47:04Z |
| publishDate | 2017-01-01 |
| publisher | Prince of Songkla University |
| record_format | Article |
| series | Journal of Health Science and Medical Research (JHSMR) |
| spelling | doaj.art-194fdcf68b1a4836827d8ca63affa89e2022-12-21T20:20:43ZengPrince of Songkla UniversityJournal of Health Science and Medical Research (JHSMR)2586-99812630-05592017-01-013518394149Several Alkaloids Derived from Plants and Their Underlying Molecular Mechanisms of Action in the Fight Against CancerSiribhorn Madla0Potchanapond Graidist1Department of Biomedical Sciences, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla 90110,The Excellence Research Laboratory of Cancer Molecular Biology, Department of Biomedical Sciences, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla 90110,Multidrug resistance is one of the major obstacles to successful cancer chemotherapy, which causes cancer to remain one of the leading causes of death worldwide. Therefore, the use of natural products for cancer prevention and therapy has been continuously investigated and developed for decades. Alkaloids are one of the important compounds derived from natural products that have been extensively studied for their potential use as cancer chemopreventive and chemotherapeutic drugs in both in vitro and animal studies. This short review intends to present the molecular mechanisms of action of alkaloids on stimulation and inhibition some signaling molecules involved in cell proliferation, differentiation, angiogenesis, metastasis and apoptosis pathways of cancer cells. The understanding of the molecular mechanisms of alkaloids against cancer will provide clues towards a diagnostic, prevention and therapeutic applications. Based on the information provided in this article, alkaloids show remarkable potential as anticancer agents. However, more research and clinical trials are crucial before applying any of these alkaloids as new medicine to treat cancer patients.https://www.jhsmr.org/index.php/jhsmr/article/view/135alkaloidsanticancer activityanticancer mechanismcancermultidrug resistance |
| spellingShingle | Siribhorn Madla Potchanapond Graidist Several Alkaloids Derived from Plants and Their Underlying Molecular Mechanisms of Action in the Fight Against Cancer Journal of Health Science and Medical Research (JHSMR) alkaloids anticancer activity anticancer mechanism cancer multidrug resistance |
| title | Several Alkaloids Derived from Plants and Their Underlying Molecular Mechanisms of Action in the Fight Against Cancer |
| title_full | Several Alkaloids Derived from Plants and Their Underlying Molecular Mechanisms of Action in the Fight Against Cancer |
| title_fullStr | Several Alkaloids Derived from Plants and Their Underlying Molecular Mechanisms of Action in the Fight Against Cancer |
| title_full_unstemmed | Several Alkaloids Derived from Plants and Their Underlying Molecular Mechanisms of Action in the Fight Against Cancer |
| title_short | Several Alkaloids Derived from Plants and Their Underlying Molecular Mechanisms of Action in the Fight Against Cancer |
| title_sort | several alkaloids derived from plants and their underlying molecular mechanisms of action in the fight against cancer |
| topic | alkaloids anticancer activity anticancer mechanism cancer multidrug resistance |
| url | https://www.jhsmr.org/index.php/jhsmr/article/view/135 |
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