Genome-wide RNAi screening identifies TMIGD3 isoform1 as a suppressor of NF-κB and osteosarcoma progression
The ability of cancer cells to survive in anchorage-independent conditions correlates with cancer aggressiveness. Here, by screening a human whole-genome shRNA library for the ability of osteosarcoma cells to form spheres in vitro, the authors identify a role for TMIGD3 isoform 1 in suppressing the...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2016-11-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms13561 |
| _version_ | 1818978500514676736 |
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| author | Swathi V. Iyer Atul Ranjan Harold K. Elias Alejandro Parrales Hiromi Sasaki Badal C. Roy Shahid Umar Ossama W. Tawfik Tomoo Iwakuma |
| author_facet | Swathi V. Iyer Atul Ranjan Harold K. Elias Alejandro Parrales Hiromi Sasaki Badal C. Roy Shahid Umar Ossama W. Tawfik Tomoo Iwakuma |
| author_sort | Swathi V. Iyer |
| collection | DOAJ |
| description | The ability of cancer cells to survive in anchorage-independent conditions correlates with cancer aggressiveness. Here, by screening a human whole-genome shRNA library for the ability of osteosarcoma cells to form spheres in vitro, the authors identify a role for TMIGD3 isoform 1 in suppressing the metastatic potential of osteosarcoma. |
| first_indexed | 2024-12-20T16:44:38Z |
| format | Article |
| id | doaj.art-19507a575f184165b6f54592493cb519 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-20T16:44:38Z |
| publishDate | 2016-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-19507a575f184165b6f54592493cb5192022-12-21T19:32:58ZengNature PortfolioNature Communications2041-17232016-11-017111310.1038/ncomms13561Genome-wide RNAi screening identifies TMIGD3 isoform1 as a suppressor of NF-κB and osteosarcoma progressionSwathi V. Iyer0Atul Ranjan1Harold K. Elias2Alejandro Parrales3Hiromi Sasaki4Badal C. Roy5Shahid Umar6Ossama W. Tawfik7Tomoo Iwakuma8Department of Cancer Biology, University of Kansas Medical CenterDepartment of Cancer Biology, University of Kansas Medical CenterDepartment of Internal Medicine, Icahn School of Medicine at Mount SinaiDepartment of Cancer Biology, University of Kansas Medical CenterDepartment of Cancer Biology, University of Kansas Medical CenterDepartment of Surgery, University of Kansas Medical CenterDepartment of Surgery, University of Kansas Medical CenterDepartment of Pathology and Laboratory Medicine, University of Kansas Medical CenterDepartment of Cancer Biology, University of Kansas Medical CenterThe ability of cancer cells to survive in anchorage-independent conditions correlates with cancer aggressiveness. Here, by screening a human whole-genome shRNA library for the ability of osteosarcoma cells to form spheres in vitro, the authors identify a role for TMIGD3 isoform 1 in suppressing the metastatic potential of osteosarcoma.https://doi.org/10.1038/ncomms13561 |
| spellingShingle | Swathi V. Iyer Atul Ranjan Harold K. Elias Alejandro Parrales Hiromi Sasaki Badal C. Roy Shahid Umar Ossama W. Tawfik Tomoo Iwakuma Genome-wide RNAi screening identifies TMIGD3 isoform1 as a suppressor of NF-κB and osteosarcoma progression Nature Communications |
| title | Genome-wide RNAi screening identifies TMIGD3 isoform1 as a suppressor of NF-κB and osteosarcoma progression |
| title_full | Genome-wide RNAi screening identifies TMIGD3 isoform1 as a suppressor of NF-κB and osteosarcoma progression |
| title_fullStr | Genome-wide RNAi screening identifies TMIGD3 isoform1 as a suppressor of NF-κB and osteosarcoma progression |
| title_full_unstemmed | Genome-wide RNAi screening identifies TMIGD3 isoform1 as a suppressor of NF-κB and osteosarcoma progression |
| title_short | Genome-wide RNAi screening identifies TMIGD3 isoform1 as a suppressor of NF-κB and osteosarcoma progression |
| title_sort | genome wide rnai screening identifies tmigd3 isoform1 as a suppressor of nf κb and osteosarcoma progression |
| url | https://doi.org/10.1038/ncomms13561 |
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