Angiolymphoid hyperplasia with eosinophilia: a case report
Abstract Background Angiolymphoid hyperplasia with eosinophilia is a benign neoplasm that includes blood vessel proliferation and a dense eosinophilic inflammatory infiltrate. Mostly, it affects middle-aged adults manifesting as flesh/plum-colored pruritic nodules and papules, most commonly affectin...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2018-04-01
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| Series: | Journal of Medical Case Reports |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s13256-018-1599-x |
| _version_ | 1828403299018080256 |
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| author | Alexey Youssef Ali Ramez Hasan Youssef Youssef Lina Al-soufi Yahya Elshimali Zuheir Alshehabi |
| author_facet | Alexey Youssef Ali Ramez Hasan Youssef Youssef Lina Al-soufi Yahya Elshimali Zuheir Alshehabi |
| author_sort | Alexey Youssef |
| collection | DOAJ |
| description | Abstract Background Angiolymphoid hyperplasia with eosinophilia is a benign neoplasm that includes blood vessel proliferation and a dense eosinophilic inflammatory infiltrate. Mostly, it affects middle-aged adults manifesting as flesh/plum-colored pruritic nodules and papules, most commonly affecting the ear and the periauricular area. Case presentation In this case, we report a 13-year-old Caucasian girl with bilateral, huge, protruding, and yellowish nostril masses which were peculiar in location and of gross appearance. At first, the disease proved to be a diagnostic dilemma. After making a diagnosis of angiolymphoid hyperplasia with eosinophilia, the disease also proved to be a therapeutic dilemma. It did not respond to oral prednisolone or to oral indomethacin, and it proved to be resistant to topical steroids. Although surgery is the standard therapeutic approach, it recurred despite multiple surgical attempts. However, the only regimen that seemed to partially control the lesion was intralesional steroids combined with topical tacrolimus ointment. Conclusions Angiolymphoid hyperplasia with eosinophilia proves a therapeutic dilemma, because there is a large variety of proposed treatments, yet there is not enough data on most of them. Although the disease is not deadly by itself, it usually presents with disfiguring lesions that grimly affect the patient’s quality of life. This warrants further research and efforts to find an effective cure and a unified therapeutic approach. |
| first_indexed | 2024-12-10T10:16:45Z |
| format | Article |
| id | doaj.art-19508a98e6c7445786f898a5738b7628 |
| institution | Directory Open Access Journal |
| issn | 1752-1947 |
| language | English |
| last_indexed | 2024-12-10T10:16:45Z |
| publishDate | 2018-04-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Medical Case Reports |
| spelling | doaj.art-19508a98e6c7445786f898a5738b76282022-12-22T01:52:59ZengBMCJournal of Medical Case Reports1752-19472018-04-011211610.1186/s13256-018-1599-xAngiolymphoid hyperplasia with eosinophilia: a case reportAlexey Youssef0Ali Ramez Hasan1Youssef Youssef2Lina Al-soufi3Yahya Elshimali4Zuheir Alshehabi5Faculty of Medicine, Tishreen UniversityFaculty of Medicine, Tishreen UniversityDepartment of Otolaryngology and Head and Neck Surgery, Tishreen University Hospital, Tishreen UniversityMinistry of Health, National Hospital of LattakiaDepartment of Pathology, University of California Los Angeles, Charles Drew UniversityDepartment of Pathology, Tishreen University Hospital, Tishreen UniversityAbstract Background Angiolymphoid hyperplasia with eosinophilia is a benign neoplasm that includes blood vessel proliferation and a dense eosinophilic inflammatory infiltrate. Mostly, it affects middle-aged adults manifesting as flesh/plum-colored pruritic nodules and papules, most commonly affecting the ear and the periauricular area. Case presentation In this case, we report a 13-year-old Caucasian girl with bilateral, huge, protruding, and yellowish nostril masses which were peculiar in location and of gross appearance. At first, the disease proved to be a diagnostic dilemma. After making a diagnosis of angiolymphoid hyperplasia with eosinophilia, the disease also proved to be a therapeutic dilemma. It did not respond to oral prednisolone or to oral indomethacin, and it proved to be resistant to topical steroids. Although surgery is the standard therapeutic approach, it recurred despite multiple surgical attempts. However, the only regimen that seemed to partially control the lesion was intralesional steroids combined with topical tacrolimus ointment. Conclusions Angiolymphoid hyperplasia with eosinophilia proves a therapeutic dilemma, because there is a large variety of proposed treatments, yet there is not enough data on most of them. Although the disease is not deadly by itself, it usually presents with disfiguring lesions that grimly affect the patient’s quality of life. This warrants further research and efforts to find an effective cure and a unified therapeutic approach.http://link.springer.com/article/10.1186/s13256-018-1599-xAngiolymphoid hyperplasia with eosinophiliaTherapeutic approachPediatric disordersPeculiar presentation |
| spellingShingle | Alexey Youssef Ali Ramez Hasan Youssef Youssef Lina Al-soufi Yahya Elshimali Zuheir Alshehabi Angiolymphoid hyperplasia with eosinophilia: a case report Journal of Medical Case Reports Angiolymphoid hyperplasia with eosinophilia Therapeutic approach Pediatric disorders Peculiar presentation |
| title | Angiolymphoid hyperplasia with eosinophilia: a case report |
| title_full | Angiolymphoid hyperplasia with eosinophilia: a case report |
| title_fullStr | Angiolymphoid hyperplasia with eosinophilia: a case report |
| title_full_unstemmed | Angiolymphoid hyperplasia with eosinophilia: a case report |
| title_short | Angiolymphoid hyperplasia with eosinophilia: a case report |
| title_sort | angiolymphoid hyperplasia with eosinophilia a case report |
| topic | Angiolymphoid hyperplasia with eosinophilia Therapeutic approach Pediatric disorders Peculiar presentation |
| url | http://link.springer.com/article/10.1186/s13256-018-1599-x |
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