Sarcomatoid variant of Xp11 translocation renal cell carcinoma: A rare case report in an adult female
Xp11 translocation renal cell carcinoma (XPTRCC) is a very rare kidney neoplasm, which has been predominantly reported in young patients. Sarcomatoid transformation in renal cell carcinomas is known. However, its occurrence in XPTRCC is unreported so far in the literature. We report a unique case of...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2023-01-01
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| Series: | Indian Journal of Pathology and Microbiology |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.4103/ijpm.ijpm_1159_21 |
| _version_ | 1826860172781289472 |
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| author | Rakhi V. Jagdale Supriya Jain Jaydeep N. Pol Makarand V. Khochikar |
| author_facet | Rakhi V. Jagdale Supriya Jain Jaydeep N. Pol Makarand V. Khochikar |
| author_sort | Rakhi V. Jagdale |
| collection | DOAJ |
| description | Xp11 translocation renal cell carcinoma (XPTRCC) is a very rare kidney neoplasm, which has been predominantly reported in young patients. Sarcomatoid transformation in renal cell carcinomas is known. However, its occurrence in XPTRCC is unreported so far in the literature. We report a unique case of sarcomatoid transformation in a XPTRCC in a 23-year-old female, who presented with a huge right-sided renal mass and had metastatic deposits in lungs. Morphologically, clear cell morphology with papillary architecture along with foci of sarcomatoid transformation and rhabdoid differentiation were noted. Immunohistochemistry showed Pax-8 and TFE-3 expression in all components including the sarcomatous areas, whereas CK and EMA were expressed in conventional clear cell component. We present an extremely rare case of sarcomatous transformation in XPTRCC and discuss the case as determined by histopathology and immunocytochemistry. To our knowledge, this is the first case of sarcomatoid transformation XPTRCC being reported in the world literature. |
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| format | Article |
| id | doaj.art-19510bdb28fd45a1aeea593a3756d128 |
| institution | Directory Open Access Journal |
| issn | 0377-4929 0974-5130 |
| language | English |
| last_indexed | 2025-02-16T19:43:43Z |
| publishDate | 2023-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
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| series | Indian Journal of Pathology and Microbiology |
| spelling | doaj.art-19510bdb28fd45a1aeea593a3756d1282025-01-22T15:13:55ZengWolters Kluwer Medknow PublicationsIndian Journal of Pathology and Microbiology0377-49290974-51302023-01-0167117818110.4103/ijpm.ijpm_1159_21Sarcomatoid variant of Xp11 translocation renal cell carcinoma: A rare case report in an adult femaleRakhi V. JagdaleSupriya JainJaydeep N. PolMakarand V. KhochikarXp11 translocation renal cell carcinoma (XPTRCC) is a very rare kidney neoplasm, which has been predominantly reported in young patients. Sarcomatoid transformation in renal cell carcinomas is known. However, its occurrence in XPTRCC is unreported so far in the literature. We report a unique case of sarcomatoid transformation in a XPTRCC in a 23-year-old female, who presented with a huge right-sided renal mass and had metastatic deposits in lungs. Morphologically, clear cell morphology with papillary architecture along with foci of sarcomatoid transformation and rhabdoid differentiation were noted. Immunohistochemistry showed Pax-8 and TFE-3 expression in all components including the sarcomatous areas, whereas CK and EMA were expressed in conventional clear cell component. We present an extremely rare case of sarcomatous transformation in XPTRCC and discuss the case as determined by histopathology and immunocytochemistry. To our knowledge, this is the first case of sarcomatoid transformation XPTRCC being reported in the world literature.https://journals.lww.com/10.4103/ijpm.ijpm_1159_21sarcomatoid transformationtfe-3xp11 translocation carcinoma |
| spellingShingle | Rakhi V. Jagdale Supriya Jain Jaydeep N. Pol Makarand V. Khochikar Sarcomatoid variant of Xp11 translocation renal cell carcinoma: A rare case report in an adult female Indian Journal of Pathology and Microbiology sarcomatoid transformation tfe-3 xp11 translocation carcinoma |
| title | Sarcomatoid variant of Xp11 translocation renal cell carcinoma: A rare case report in an adult female |
| title_full | Sarcomatoid variant of Xp11 translocation renal cell carcinoma: A rare case report in an adult female |
| title_fullStr | Sarcomatoid variant of Xp11 translocation renal cell carcinoma: A rare case report in an adult female |
| title_full_unstemmed | Sarcomatoid variant of Xp11 translocation renal cell carcinoma: A rare case report in an adult female |
| title_short | Sarcomatoid variant of Xp11 translocation renal cell carcinoma: A rare case report in an adult female |
| title_sort | sarcomatoid variant of xp11 translocation renal cell carcinoma a rare case report in an adult female |
| topic | sarcomatoid transformation tfe-3 xp11 translocation carcinoma |
| url | https://journals.lww.com/10.4103/ijpm.ijpm_1159_21 |
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