Effect of silver/zinc co-dopant on enhancing cytotoxicity and antibacterial property of spray pyrolyzed bioactive glasses
ABSTRACTOwing to the advancement of bioactive materials, bioactive glasses (BGs) are progressively being recognized as promising choices in fields of bone and tissue engineering with their superior properties such as bioactivity and biocompatibility. However, their applications are limited by the fa...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2024-01-01
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| Series: | Journal of Asian Ceramic Societies |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/21870764.2024.2311968 |
| _version_ | 1827572929737523200 |
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| author | Henni Setia Ningsih Frizka Vietanti Chin-Chean Wong Yu-Jen Chou |
| author_facet | Henni Setia Ningsih Frizka Vietanti Chin-Chean Wong Yu-Jen Chou |
| author_sort | Henni Setia Ningsih |
| collection | DOAJ |
| description | ABSTRACTOwing to the advancement of bioactive materials, bioactive glasses (BGs) are progressively being recognized as promising choices in fields of bone and tissue engineering with their superior properties such as bioactivity and biocompatibility. However, their applications are limited by the fact that the material itself does not possess antibacterial properties. To address this limitation, antibacterial BGs with silver-zinc co-dopant were proposed and successfully synthesized via the one-step spray pyrolysis technique in this work. The phase composition, chemical composition, surface morphology, and nanoscale structures of the obtained BG specimens were characterized using X-ray diffraction, energy dispersive spectroscopy, scanning electron microscopy, and transmission electron microscopy. Moreover, in-vitro bioactivity was assessed through immersion of the SBF solution, while the in-vitro antibacterial property was examined using Escherichia coli bacteria. Meanwhile, the viability of MC3T3-E1 osteoblast cells was evaluated using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. Finally, the results showed positive effects of zinc addition, and the influence of silver and zinc dopants on the in-vitro bioactivity, antibacterial property, and cell viability were discussed. |
| first_indexed | 2024-03-07T19:59:47Z |
| format | Article |
| id | doaj.art-1952d0db45684480ac930eeda637250c |
| institution | Directory Open Access Journal |
| issn | 2187-0764 |
| language | English |
| last_indexed | 2024-03-07T19:59:47Z |
| publishDate | 2024-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Journal of Asian Ceramic Societies |
| spelling | doaj.art-1952d0db45684480ac930eeda637250c2024-02-28T10:00:57ZengTaylor & Francis GroupJournal of Asian Ceramic Societies2187-07642024-01-0112110411610.1080/21870764.2024.2311968Effect of silver/zinc co-dopant on enhancing cytotoxicity and antibacterial property of spray pyrolyzed bioactive glassesHenni Setia Ningsih0Frizka Vietanti1Chin-Chean Wong2Yu-Jen Chou3Department of Mechanical Engineering, National Taiwan University of Science and Technology, Taipei, TaiwanDepartment of Mechanical Engineering, National Taiwan University of Science and Technology, Taipei, TaiwanDepartment of Orthopedics, Taipei Medical University Shuang Ho Hospital, New Taipei City, TaiwanDepartment of Mechanical Engineering, National Taiwan University of Science and Technology, Taipei, TaiwanABSTRACTOwing to the advancement of bioactive materials, bioactive glasses (BGs) are progressively being recognized as promising choices in fields of bone and tissue engineering with their superior properties such as bioactivity and biocompatibility. However, their applications are limited by the fact that the material itself does not possess antibacterial properties. To address this limitation, antibacterial BGs with silver-zinc co-dopant were proposed and successfully synthesized via the one-step spray pyrolysis technique in this work. The phase composition, chemical composition, surface morphology, and nanoscale structures of the obtained BG specimens were characterized using X-ray diffraction, energy dispersive spectroscopy, scanning electron microscopy, and transmission electron microscopy. Moreover, in-vitro bioactivity was assessed through immersion of the SBF solution, while the in-vitro antibacterial property was examined using Escherichia coli bacteria. Meanwhile, the viability of MC3T3-E1 osteoblast cells was evaluated using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. Finally, the results showed positive effects of zinc addition, and the influence of silver and zinc dopants on the in-vitro bioactivity, antibacterial property, and cell viability were discussed.https://www.tandfonline.com/doi/10.1080/21870764.2024.2311968Bioactive glassSpray pyrolysisAntibacterialElectron microscopy |
| spellingShingle | Henni Setia Ningsih Frizka Vietanti Chin-Chean Wong Yu-Jen Chou Effect of silver/zinc co-dopant on enhancing cytotoxicity and antibacterial property of spray pyrolyzed bioactive glasses Journal of Asian Ceramic Societies Bioactive glass Spray pyrolysis Antibacterial Electron microscopy |
| title | Effect of silver/zinc co-dopant on enhancing cytotoxicity and antibacterial property of spray pyrolyzed bioactive glasses |
| title_full | Effect of silver/zinc co-dopant on enhancing cytotoxicity and antibacterial property of spray pyrolyzed bioactive glasses |
| title_fullStr | Effect of silver/zinc co-dopant on enhancing cytotoxicity and antibacterial property of spray pyrolyzed bioactive glasses |
| title_full_unstemmed | Effect of silver/zinc co-dopant on enhancing cytotoxicity and antibacterial property of spray pyrolyzed bioactive glasses |
| title_short | Effect of silver/zinc co-dopant on enhancing cytotoxicity and antibacterial property of spray pyrolyzed bioactive glasses |
| title_sort | effect of silver zinc co dopant on enhancing cytotoxicity and antibacterial property of spray pyrolyzed bioactive glasses |
| topic | Bioactive glass Spray pyrolysis Antibacterial Electron microscopy |
| url | https://www.tandfonline.com/doi/10.1080/21870764.2024.2311968 |
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