Bio-jetted human adipose-derived stem cells remain viable
Direct cell handling processes are increasingly becoming important as they allow the controlled deposition of living cells, with precision for a vast number of applications, spanning the printing of cells in either 2D/3D for the reconstruction of fully functional tissues to the delivery of therapeut...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2024-01-01
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| Series: | Next Materials |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2949822824000054 |
| _version_ | 1797237734737182720 |
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| author | Prasad Sawadkar Ferdinand Lali Suwan N. Jayasinghe |
| author_facet | Prasad Sawadkar Ferdinand Lali Suwan N. Jayasinghe |
| author_sort | Prasad Sawadkar |
| collection | DOAJ |
| description | Direct cell handling processes are increasingly becoming important as they allow the controlled deposition of living cells, with precision for a vast number of applications, spanning the printing of cells in either 2D/3D for the reconstruction of fully functional tissues to the delivery of therapeutic architectures bearing cells and genes of interest. Architectures reconstructed with such cells etc are most useful as models, for studying a wide range of molecular and cellular behaviours, to the development of personalised medicines. Our previous work demonstrated the ability for aerodynamically assisted bio-jets to process single and multiple cell-bearing suspensions, to whole fertilised embryos. Those studies found that the post-treated cells and embryos were indistinguishable from untreated controls. In the present study the authors further validate this jetting technology for the direct handling of stem cells, by demonstrating their viability post-treatment and their capacity to differentiate in comparison to controls. These studies together with our previous work unveil, aerodynamically assisted bio-jets as a platform biotechnology for the direct handling of a wide range of cells and embryos. |
| first_indexed | 2024-04-24T17:24:28Z |
| format | Article |
| id | doaj.art-1953318a8d364e728418f415bf94a2e1 |
| institution | Directory Open Access Journal |
| issn | 2949-8228 |
| language | English |
| last_indexed | 2024-04-24T17:24:28Z |
| publishDate | 2024-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Next Materials |
| spelling | doaj.art-1953318a8d364e728418f415bf94a2e12024-03-28T06:41:16ZengElsevierNext Materials2949-82282024-01-012100108Bio-jetted human adipose-derived stem cells remain viablePrasad Sawadkar0Ferdinand Lali1Suwan N. Jayasinghe2The Griffin Institute - Northwick Park Institute for Medical Research, Northwick Park and St Mark’s Hospitals, Y Block, Watford Road, Harrow, Middlesex HA1 3UJ, United Kingdom; Division of Surgery and Interventional Science, University College London, 43-45 Foley St, London W1W 7TY, United KingdomThe Griffin Institute - Northwick Park Institute for Medical Research, Northwick Park and St Mark’s Hospitals, Y Block, Watford Road, Harrow, Middlesex HA1 3UJ, United Kingdom; Division of Surgery and Interventional Science, University College London, 43-45 Foley St, London W1W 7TY, United KingdomBioPhysics Group, Centre for Stem Cells and Regenerative Medicine, and Department of Mechanical Engineering, University College London, Torrington Place, London WC1E 7JE, United Kingdom; Corresponding author.Direct cell handling processes are increasingly becoming important as they allow the controlled deposition of living cells, with precision for a vast number of applications, spanning the printing of cells in either 2D/3D for the reconstruction of fully functional tissues to the delivery of therapeutic architectures bearing cells and genes of interest. Architectures reconstructed with such cells etc are most useful as models, for studying a wide range of molecular and cellular behaviours, to the development of personalised medicines. Our previous work demonstrated the ability for aerodynamically assisted bio-jets to process single and multiple cell-bearing suspensions, to whole fertilised embryos. Those studies found that the post-treated cells and embryos were indistinguishable from untreated controls. In the present study the authors further validate this jetting technology for the direct handling of stem cells, by demonstrating their viability post-treatment and their capacity to differentiate in comparison to controls. These studies together with our previous work unveil, aerodynamically assisted bio-jets as a platform biotechnology for the direct handling of a wide range of cells and embryos.http://www.sciencedirect.com/science/article/pii/S2949822824000054Aerodynamically assisted bio-jetsHuman adipose-derived stem cells (hADSCs)ViabilityDifferentiationRegenerative medicine and biology |
| spellingShingle | Prasad Sawadkar Ferdinand Lali Suwan N. Jayasinghe Bio-jetted human adipose-derived stem cells remain viable Next Materials Aerodynamically assisted bio-jets Human adipose-derived stem cells (hADSCs) Viability Differentiation Regenerative medicine and biology |
| title | Bio-jetted human adipose-derived stem cells remain viable |
| title_full | Bio-jetted human adipose-derived stem cells remain viable |
| title_fullStr | Bio-jetted human adipose-derived stem cells remain viable |
| title_full_unstemmed | Bio-jetted human adipose-derived stem cells remain viable |
| title_short | Bio-jetted human adipose-derived stem cells remain viable |
| title_sort | bio jetted human adipose derived stem cells remain viable |
| topic | Aerodynamically assisted bio-jets Human adipose-derived stem cells (hADSCs) Viability Differentiation Regenerative medicine and biology |
| url | http://www.sciencedirect.com/science/article/pii/S2949822824000054 |
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