Mice Deficient in Epithelial or Myeloid Cell Iκκβ Have Distinct Colonic Microbiomes and Increased Resistance to Citrobacter rodentium Infection

Mice Deficient in Epithelial or Myeloid Cell Iκκβ Have Distinct Colonic Microbiomes and Increased Resistance to Citrobacter rodentium Infection

The colonic microenvironment, stemming from microbial, immunologic, stromal, and epithelial factors, serves as an important determinant of the host response to enteric pathogenic colonization. Infection with the enteric bacterial pathogen Citrobacter rodentium elicits a strong mucosal Th1-mediated c...

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Bibliographic Details
Main Authors: Amy R. Mackos, Jacob M. Allen, Eunsoo Kim, Chris A. Ladaika, Raad Z. Gharaibeh, Cathy Moore, Nicola M. A. Parry, Prosper N. Boyaka, Michael T. Bailey
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-09-01
Series:Frontiers in Immunology
Subjects:
Citrobacter rodentium
NF-κB
colonic epithelial cells
microbiota
colitis
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.02062/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.02062/full

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