Silent myelin-weighted magnetic resonance imaging [version 2; peer review: 2 approved, 2 approved with reservations]
Background: Inhomogeneous Magnetization Transfer (ihMT) is an emerging, uniquely myelin-specific magnetic resonance imaging (MRI) contrast. Current ihMT acquisitions utilise fast Gradient Echo sequences which are among the most acoustically noisy MRI sequences, reducing patient comfort during acquis...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wellcome
2020-08-01
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| Series: | Wellcome Open Research |
| Online Access: | https://wellcomeopenresearch.org/articles/5-74/v2 |
| _version_ | 1818158151381286912 |
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| author | Tobias C. Wood Nikou L. Damestani Andrew J. Lawrence Emil Ljungberg Gareth J. Barker Ana Beatriz Solana Florian Wiesinger Steven C.R. Williams |
| author_facet | Tobias C. Wood Nikou L. Damestani Andrew J. Lawrence Emil Ljungberg Gareth J. Barker Ana Beatriz Solana Florian Wiesinger Steven C.R. Williams |
| author_sort | Tobias C. Wood |
| collection | DOAJ |
| description | Background: Inhomogeneous Magnetization Transfer (ihMT) is an emerging, uniquely myelin-specific magnetic resonance imaging (MRI) contrast. Current ihMT acquisitions utilise fast Gradient Echo sequences which are among the most acoustically noisy MRI sequences, reducing patient comfort during acquisition. We sought to address this by modifying a near silent MRI sequence to include ihMT contrast. Methods: A Magnetization Transfer preparation module was incorporated into a radial Zero Echo-Time sequence. Repeatability of the ihMT ratio and inverse ihMT ratio were assessed in a cohort of healthy subjects. We also investigated how head orientation affects ihMT across subjects, as a previous study in a single subject suggests this as a potential confound. Results: We demonstrated that ihMT ratios comparable to existing, acoustically loud, implementations could be obtained with the silent sequence. We observed a small but significant effect of head orientation on inverse ihMTR. Conclusions: Silent ihMT imaging is a comparable alternative to conventional, noisy, alternatives. For all future ihMT studies we recommend careful positioning of the subject within the scanner. |
| first_indexed | 2024-12-11T15:25:32Z |
| format | Article |
| id | doaj.art-1955ab5a4f4342e2b9dfa937909dc24a |
| institution | Directory Open Access Journal |
| issn | 2398-502X |
| language | English |
| last_indexed | 2024-12-11T15:25:32Z |
| publishDate | 2020-08-01 |
| publisher | Wellcome |
| record_format | Article |
| series | Wellcome Open Research |
| spelling | doaj.art-1955ab5a4f4342e2b9dfa937909dc24a2022-12-22T01:00:13ZengWellcomeWellcome Open Research2398-502X2020-08-01510.12688/wellcomeopenres.15845.217734Silent myelin-weighted magnetic resonance imaging [version 2; peer review: 2 approved, 2 approved with reservations]Tobias C. Wood0Nikou L. Damestani1Andrew J. Lawrence2Emil Ljungberg3Gareth J. Barker4Ana Beatriz Solana5Florian Wiesinger6Steven C.R. Williams7Department of Neuroimaging, King's College London, London, UKDepartment of Neuroimaging, King's College London, London, UKDepartment of Psychological Medicine, King's College London, London, UKDepartment of Neuroimaging, King's College London, London, UKDepartment of Neuroimaging, King's College London, London, UKASL Europe, GE Healthcare, Munich, GermanyASL Europe, GE Healthcare, Munich, GermanyDepartment of Neuroimaging, King's College London, London, UKBackground: Inhomogeneous Magnetization Transfer (ihMT) is an emerging, uniquely myelin-specific magnetic resonance imaging (MRI) contrast. Current ihMT acquisitions utilise fast Gradient Echo sequences which are among the most acoustically noisy MRI sequences, reducing patient comfort during acquisition. We sought to address this by modifying a near silent MRI sequence to include ihMT contrast. Methods: A Magnetization Transfer preparation module was incorporated into a radial Zero Echo-Time sequence. Repeatability of the ihMT ratio and inverse ihMT ratio were assessed in a cohort of healthy subjects. We also investigated how head orientation affects ihMT across subjects, as a previous study in a single subject suggests this as a potential confound. Results: We demonstrated that ihMT ratios comparable to existing, acoustically loud, implementations could be obtained with the silent sequence. We observed a small but significant effect of head orientation on inverse ihMTR. Conclusions: Silent ihMT imaging is a comparable alternative to conventional, noisy, alternatives. For all future ihMT studies we recommend careful positioning of the subject within the scanner.https://wellcomeopenresearch.org/articles/5-74/v2 |
| spellingShingle | Tobias C. Wood Nikou L. Damestani Andrew J. Lawrence Emil Ljungberg Gareth J. Barker Ana Beatriz Solana Florian Wiesinger Steven C.R. Williams Silent myelin-weighted magnetic resonance imaging [version 2; peer review: 2 approved, 2 approved with reservations] Wellcome Open Research |
| title | Silent myelin-weighted magnetic resonance imaging [version 2; peer review: 2 approved, 2 approved with reservations] |
| title_full | Silent myelin-weighted magnetic resonance imaging [version 2; peer review: 2 approved, 2 approved with reservations] |
| title_fullStr | Silent myelin-weighted magnetic resonance imaging [version 2; peer review: 2 approved, 2 approved with reservations] |
| title_full_unstemmed | Silent myelin-weighted magnetic resonance imaging [version 2; peer review: 2 approved, 2 approved with reservations] |
| title_short | Silent myelin-weighted magnetic resonance imaging [version 2; peer review: 2 approved, 2 approved with reservations] |
| title_sort | silent myelin weighted magnetic resonance imaging version 2 peer review 2 approved 2 approved with reservations |
| url | https://wellcomeopenresearch.org/articles/5-74/v2 |
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