Intersection of Epigenetic and Metabolic Regulation of Histone Modifications in Acute Myeloid Leukemia

Intersection of Epigenetic and Metabolic Regulation of Histone Modifications in Acute Myeloid Leukemia

Acute myeloid leukemia (AML) is one of the most lethal blood cancers, accounting for close to a quarter of a million annual deaths worldwide. Even though genetically heterogeneous, all AMLs are characterized by two interrelated features—blocked differentiation and high proliferative capacity. Despit...

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Bibliographic Details
Main Authors: Abhinav Dhall, Barry M. Zee, Fangxue Yan, M. Andres Blanco
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-05-01
Series:Frontiers in Oncology
Subjects:
AML—acute myeloid leukaemia
metabolism
histone methlyation
HDACs
epigenetics (methylation/demethylation)
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2019.00432/full

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