Country-level association between antimicrobial consumption and resistance in Neisseria meningitidis: An ecological study
Background: It is unclear what is responsible for the large variations in the prevalence of meningococcal resistance to cephalosporins and quinolones. Methods: We used mixed-effects linear regression to assess if country-level prevalence of reduced susceptibility to cefotaxime and ciprofloxacin was...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-03-01
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| Series: | Journal of Infection and Public Health |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1876034122000156 |
| _version_ | 1819121490484789248 |
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| author | Sheeba S. Manoharan-Basil Natalia Gonzalez Chris Kenyon |
| author_facet | Sheeba S. Manoharan-Basil Natalia Gonzalez Chris Kenyon |
| author_sort | Sheeba S. Manoharan-Basil |
| collection | DOAJ |
| description | Background: It is unclear what is responsible for the large variations in the prevalence of meningococcal resistance to cephalosporins and quinolones. Methods: We used mixed-effects linear regression to assess if country-level prevalence of reduced susceptibility to cefotaxime and ciprofloxacin was associated with the population-level consumption of cephalosporins and quinolones in 13 European countries. Results: Positive correlations were found between the prevalence of reduced susceptibility to ciprofloxacin and the consumption of quinolones (coef. 0.16, 95% CI 0.05–0.27; P = 0.003). The same positive association was found for cefotaxime/cephalosporins (coef. 0.1, 95% CI 0.04–0.15; P = 0.001). Conclusions: Meningococcal reduced susceptibility to cefotaxime and ciprofloxacin is linked to homologous class antimicrobial consumption. This finding provides additional motivation for strengthening antimicrobial stewardship programs. |
| first_indexed | 2024-12-22T06:37:23Z |
| format | Article |
| id | doaj.art-1959bd152a744fad9d6cfde01ed5d4bd |
| institution | Directory Open Access Journal |
| issn | 1876-0341 |
| language | English |
| last_indexed | 2024-12-22T06:37:23Z |
| publishDate | 2022-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Infection and Public Health |
| spelling | doaj.art-1959bd152a744fad9d6cfde01ed5d4bd2022-12-21T18:35:32ZengElsevierJournal of Infection and Public Health1876-03412022-03-01153293296Country-level association between antimicrobial consumption and resistance in Neisseria meningitidis: An ecological studySheeba S. Manoharan-Basil0Natalia Gonzalez1Chris Kenyon2HIV/STI Unit, Institute of Tropical Medicine, Antwerp, Belgium; Division of Infectious Diseases and HIV Medicine, University of Cape Town, Anzio Road, Observatory 7700, South AfricaHIV/STI Unit, Institute of Tropical Medicine, Antwerp, Belgium; Division of Infectious Diseases and HIV Medicine, University of Cape Town, Anzio Road, Observatory 7700, South AfricaHIV/STI Unit, Institute of Tropical Medicine, Antwerp, Belgium; Division of Infectious Diseases and HIV Medicine, University of Cape Town, Anzio Road, Observatory 7700, South Africa; Correspondence to: HIV/STI Unit, Institute of Tropical Medicine, Antwerp, 2000, Belgium.Background: It is unclear what is responsible for the large variations in the prevalence of meningococcal resistance to cephalosporins and quinolones. Methods: We used mixed-effects linear regression to assess if country-level prevalence of reduced susceptibility to cefotaxime and ciprofloxacin was associated with the population-level consumption of cephalosporins and quinolones in 13 European countries. Results: Positive correlations were found between the prevalence of reduced susceptibility to ciprofloxacin and the consumption of quinolones (coef. 0.16, 95% CI 0.05–0.27; P = 0.003). The same positive association was found for cefotaxime/cephalosporins (coef. 0.1, 95% CI 0.04–0.15; P = 0.001). Conclusions: Meningococcal reduced susceptibility to cefotaxime and ciprofloxacin is linked to homologous class antimicrobial consumption. This finding provides additional motivation for strengthening antimicrobial stewardship programs.http://www.sciencedirect.com/science/article/pii/S1876034122000156Neisseria meningitidisFluoroquinolonesQuinolonesCephalosporinsAntimicrobial resistanceStewardship |
| spellingShingle | Sheeba S. Manoharan-Basil Natalia Gonzalez Chris Kenyon Country-level association between antimicrobial consumption and resistance in Neisseria meningitidis: An ecological study Journal of Infection and Public Health Neisseria meningitidis Fluoroquinolones Quinolones Cephalosporins Antimicrobial resistance Stewardship |
| title | Country-level association between antimicrobial consumption and resistance in Neisseria meningitidis: An ecological study |
| title_full | Country-level association between antimicrobial consumption and resistance in Neisseria meningitidis: An ecological study |
| title_fullStr | Country-level association between antimicrobial consumption and resistance in Neisseria meningitidis: An ecological study |
| title_full_unstemmed | Country-level association between antimicrobial consumption and resistance in Neisseria meningitidis: An ecological study |
| title_short | Country-level association between antimicrobial consumption and resistance in Neisseria meningitidis: An ecological study |
| title_sort | country level association between antimicrobial consumption and resistance in neisseria meningitidis an ecological study |
| topic | Neisseria meningitidis Fluoroquinolones Quinolones Cephalosporins Antimicrobial resistance Stewardship |
| url | http://www.sciencedirect.com/science/article/pii/S1876034122000156 |
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