High Serum Estradiol Reduces Acute Hepatotoxicity Risk Induced by Epirubicin Plus Cyclophosphamide Chemotherapy in Premenopausal Women with Breast Cancer

High Serum Estradiol Reduces Acute Hepatotoxicity Risk Induced by Epirubicin Plus Cyclophosphamide Chemotherapy in Premenopausal Women with Breast Cancer

Aim: We evaluated whether acute drug-induced liver injury (DILI) caused by adjuvant chemotherapy with epirubicin plus cyclophosphamide for early breast cancer was associated with estradiol (E2), luteinizing hormone (LH), and follicle-stimulating hormone (FSH).Methods: Reproductive hormone test resul...

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Bibliographic Details
Main Authors: Shunmin Huang, Maobai Liu, Fangmeng Fu, Hangmin Liu, Baochang He, Danni Xiao, Jing Yang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Pharmacology
Subjects:
breast neoplasms
drug-induced liver injury
adjuvant chemotherapy
estradiol
menopause
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2020.572444/full

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