Influence of Dietary Polar Lipid Supplementation on Memory and Longitudinal Brain Development
Polar lipids, which are found in human milk, serve essential functions within biological membranes, hence their importance in brain development and cognition. Therefore, we aimed to evaluate the longitudinal effects on brain macrostructural and microstructural development and recognition memory of e...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-07-01
|
| Series: | Nutrients |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6643/13/8/2486 |
| _version_ | 1797522543042625536 |
|---|---|
| author | Joanne E. Fil Sangyun Joung Jonas Hauser Andreas Rytz Courtney A. Hayes Ryan N. Dilger |
| author_facet | Joanne E. Fil Sangyun Joung Jonas Hauser Andreas Rytz Courtney A. Hayes Ryan N. Dilger |
| author_sort | Joanne E. Fil |
| collection | DOAJ |
| description | Polar lipids, which are found in human milk, serve essential functions within biological membranes, hence their importance in brain development and cognition. Therefore, we aimed to evaluate the longitudinal effects on brain macrostructural and microstructural development and recognition memory of early-life polar lipid supplementation using the translational pig model. Twenty-eight intact (i.e., not castrated) male pigs were provided either a control diet (n = 14) or the control diet supplemented with polar lipids (n = 14) from postnatal day 2 until postnatal week 4. After postnatal week 4, all animals were provided the same nutritionally-adequate diets until postnatal week 24. Pigs underwent magnetic resonance imaging at 8 longitudinal time-points to model brain macrostructural and microstructural developmental trajectories. The novel object recognition task was implemented at postnatal weeks 4 and 8 to evaluate recognition memory. Subtle differences were observed between groups in hippocampal absolute brain volumes and fractional anisotropy, and no differences in myelin water fraction developmental patterns were noted. Behavioral outcomes did not differ in recognition memory, and only minimal differences were observed in exploratory behaviors. Our findings suggest that early-life dietary supplementation of polar lipids has limited effect on brain developmental patterns, object recognition memory, and exploratory behaviors. |
| first_indexed | 2024-03-10T08:30:54Z |
| format | Article |
| id | doaj.art-195a6451ef9940d6a8613697d7e5f5b5 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T08:30:54Z |
| publishDate | 2021-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-195a6451ef9940d6a8613697d7e5f5b52023-11-22T09:01:23ZengMDPI AGNutrients2072-66432021-07-01138248610.3390/nu13082486Influence of Dietary Polar Lipid Supplementation on Memory and Longitudinal Brain DevelopmentJoanne E. Fil0Sangyun Joung1Jonas Hauser2Andreas Rytz3Courtney A. Hayes4Ryan N. Dilger5Neuroscience Program, University of Illinois, Urbana, IL 61801, USANeuroscience Program, University of Illinois, Urbana, IL 61801, USASociété des Produits Nestlé, 1000 Lausanne, SwitzerlandSociété des Produits Nestlé, 1000 Lausanne, SwitzerlandCollege of Veterinary Medicine, University of Illinois, Urbana, IL 61801, USANeuroscience Program, University of Illinois, Urbana, IL 61801, USAPolar lipids, which are found in human milk, serve essential functions within biological membranes, hence their importance in brain development and cognition. Therefore, we aimed to evaluate the longitudinal effects on brain macrostructural and microstructural development and recognition memory of early-life polar lipid supplementation using the translational pig model. Twenty-eight intact (i.e., not castrated) male pigs were provided either a control diet (n = 14) or the control diet supplemented with polar lipids (n = 14) from postnatal day 2 until postnatal week 4. After postnatal week 4, all animals were provided the same nutritionally-adequate diets until postnatal week 24. Pigs underwent magnetic resonance imaging at 8 longitudinal time-points to model brain macrostructural and microstructural developmental trajectories. The novel object recognition task was implemented at postnatal weeks 4 and 8 to evaluate recognition memory. Subtle differences were observed between groups in hippocampal absolute brain volumes and fractional anisotropy, and no differences in myelin water fraction developmental patterns were noted. Behavioral outcomes did not differ in recognition memory, and only minimal differences were observed in exploratory behaviors. Our findings suggest that early-life dietary supplementation of polar lipids has limited effect on brain developmental patterns, object recognition memory, and exploratory behaviors.https://www.mdpi.com/2072-6643/13/8/2486brainneurodevelopmentmagnetic resonance imagingbehaviorGompertzlongitudinal |
| spellingShingle | Joanne E. Fil Sangyun Joung Jonas Hauser Andreas Rytz Courtney A. Hayes Ryan N. Dilger Influence of Dietary Polar Lipid Supplementation on Memory and Longitudinal Brain Development Nutrients brain neurodevelopment magnetic resonance imaging behavior Gompertz longitudinal |
| title | Influence of Dietary Polar Lipid Supplementation on Memory and Longitudinal Brain Development |
| title_full | Influence of Dietary Polar Lipid Supplementation on Memory and Longitudinal Brain Development |
| title_fullStr | Influence of Dietary Polar Lipid Supplementation on Memory and Longitudinal Brain Development |
| title_full_unstemmed | Influence of Dietary Polar Lipid Supplementation on Memory and Longitudinal Brain Development |
| title_short | Influence of Dietary Polar Lipid Supplementation on Memory and Longitudinal Brain Development |
| title_sort | influence of dietary polar lipid supplementation on memory and longitudinal brain development |
| topic | brain neurodevelopment magnetic resonance imaging behavior Gompertz longitudinal |
| url | https://www.mdpi.com/2072-6643/13/8/2486 |
| work_keys_str_mv | AT joanneefil influenceofdietarypolarlipidsupplementationonmemoryandlongitudinalbraindevelopment AT sangyunjoung influenceofdietarypolarlipidsupplementationonmemoryandlongitudinalbraindevelopment AT jonashauser influenceofdietarypolarlipidsupplementationonmemoryandlongitudinalbraindevelopment AT andreasrytz influenceofdietarypolarlipidsupplementationonmemoryandlongitudinalbraindevelopment AT courtneyahayes influenceofdietarypolarlipidsupplementationonmemoryandlongitudinalbraindevelopment AT ryanndilger influenceofdietarypolarlipidsupplementationonmemoryandlongitudinalbraindevelopment |