Recent Advance in Small Molecules Targeting RhlR of <i>Pseudomonas</i> <i>aeruginosa</i>
<i>Pseudomonas</i> <i>aeruginosa</i> (<i>P</i>. <i>aeruginosa</i>) is an opportunistic gram-negative pathogen that can cause various infections, particularly in patients with compromised host defenses. <i>P</i>. <i>aeruginosa</i>...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-02-01
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| Series: | Antibiotics |
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| Online Access: | https://www.mdpi.com/2079-6382/11/2/274 |
| _version_ | 1797483310605139968 |
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| author | Taehyeong Lim So-Young Ham SangJin Nam Myoungsun Kim Ki Yong Lee Hee-Deung Park Youngjoo Byun |
| author_facet | Taehyeong Lim So-Young Ham SangJin Nam Myoungsun Kim Ki Yong Lee Hee-Deung Park Youngjoo Byun |
| author_sort | Taehyeong Lim |
| collection | DOAJ |
| description | <i>Pseudomonas</i> <i>aeruginosa</i> (<i>P</i>. <i>aeruginosa</i>) is an opportunistic gram-negative pathogen that can cause various infections, particularly in patients with compromised host defenses. <i>P</i>. <i>aeruginosa</i> forms biofilms and produces virulence factors through quorum sensing (QS) network, resulting in resistance to antibiotics. RhlI/RhlR, one of key QS systems in <i>P</i>. <i>aeruginosa</i>, is considered an attractive target for inhibiting biofilm formation and attenuating virulence factors. Several recent studies examined small molecules targeting the RhlI/RhlR system and their in vitro and in vivo biological activities. In this review, RhlR-targeted modulators, including agonists and antagonists, are discussed with particular focus on structure-activity relationship studies and outlook for next-generation anti-biofilm agents. |
| first_indexed | 2024-03-09T22:45:10Z |
| format | Article |
| id | doaj.art-195cdf1937af44c1b25b39e5dd3c97a3 |
| institution | Directory Open Access Journal |
| issn | 2079-6382 |
| language | English |
| last_indexed | 2024-03-09T22:45:10Z |
| publishDate | 2022-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antibiotics |
| spelling | doaj.art-195cdf1937af44c1b25b39e5dd3c97a32023-11-23T18:29:25ZengMDPI AGAntibiotics2079-63822022-02-0111227410.3390/antibiotics11020274Recent Advance in Small Molecules Targeting RhlR of <i>Pseudomonas</i> <i>aeruginosa</i>Taehyeong Lim0So-Young Ham1SangJin Nam2Myoungsun Kim3Ki Yong Lee4Hee-Deung Park5Youngjoo Byun6College of Pharmacy, Korea University, Sejong 30019, KoreaSchool of Civil, Environmental and Architectural Engineering, Korea University, Seoul 02841, KoreaCollege of Pharmacy, Korea University, Sejong 30019, KoreaCollege of Pharmacy, Korea University, Sejong 30019, KoreaCollege of Pharmacy, Korea University, Sejong 30019, KoreaSchool of Civil, Environmental and Architectural Engineering, Korea University, Seoul 02841, KoreaCollege of Pharmacy, Korea University, Sejong 30019, Korea<i>Pseudomonas</i> <i>aeruginosa</i> (<i>P</i>. <i>aeruginosa</i>) is an opportunistic gram-negative pathogen that can cause various infections, particularly in patients with compromised host defenses. <i>P</i>. <i>aeruginosa</i> forms biofilms and produces virulence factors through quorum sensing (QS) network, resulting in resistance to antibiotics. RhlI/RhlR, one of key QS systems in <i>P</i>. <i>aeruginosa</i>, is considered an attractive target for inhibiting biofilm formation and attenuating virulence factors. Several recent studies examined small molecules targeting the RhlI/RhlR system and their in vitro and in vivo biological activities. In this review, RhlR-targeted modulators, including agonists and antagonists, are discussed with particular focus on structure-activity relationship studies and outlook for next-generation anti-biofilm agents.https://www.mdpi.com/2079-6382/11/2/274<i>Pseudomonas</i> <i>aeruginosa</i>RhlRbiofilm |
| spellingShingle | Taehyeong Lim So-Young Ham SangJin Nam Myoungsun Kim Ki Yong Lee Hee-Deung Park Youngjoo Byun Recent Advance in Small Molecules Targeting RhlR of <i>Pseudomonas</i> <i>aeruginosa</i> Antibiotics <i>Pseudomonas</i> <i>aeruginosa</i> RhlR biofilm |
| title | Recent Advance in Small Molecules Targeting RhlR of <i>Pseudomonas</i> <i>aeruginosa</i> |
| title_full | Recent Advance in Small Molecules Targeting RhlR of <i>Pseudomonas</i> <i>aeruginosa</i> |
| title_fullStr | Recent Advance in Small Molecules Targeting RhlR of <i>Pseudomonas</i> <i>aeruginosa</i> |
| title_full_unstemmed | Recent Advance in Small Molecules Targeting RhlR of <i>Pseudomonas</i> <i>aeruginosa</i> |
| title_short | Recent Advance in Small Molecules Targeting RhlR of <i>Pseudomonas</i> <i>aeruginosa</i> |
| title_sort | recent advance in small molecules targeting rhlr of i pseudomonas i i aeruginosa i |
| topic | <i>Pseudomonas</i> <i>aeruginosa</i> RhlR biofilm |
| url | https://www.mdpi.com/2079-6382/11/2/274 |
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