Structural determinants of Rab11 activation by the guanine nucleotide exchange factor SH3BP5
Rab11 GTPases are involved in various cellular processes but their activation by guanine nucleotide exchange factors (GEFs) is not fully understood. Here, the authors present a structural and biochemical analysis of Rab11 bound to the GEF SH3BP5, providing insights how Rab-GEF specificity is achieve...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2018-09-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-018-06196-z |
| _version_ | 1818341633185284096 |
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| author | Meredith L. Jenkins Jean Piero Margaria Jordan T. B. Stariha Reece M. Hoffmann Jacob A. McPhail David J. Hamelin Martin J. Boulanger Emilio Hirsch John E. Burke |
| author_facet | Meredith L. Jenkins Jean Piero Margaria Jordan T. B. Stariha Reece M. Hoffmann Jacob A. McPhail David J. Hamelin Martin J. Boulanger Emilio Hirsch John E. Burke |
| author_sort | Meredith L. Jenkins |
| collection | DOAJ |
| description | Rab11 GTPases are involved in various cellular processes but their activation by guanine nucleotide exchange factors (GEFs) is not fully understood. Here, the authors present a structural and biochemical analysis of Rab11 bound to the GEF SH3BP5, providing insights how Rab-GEF specificity is achieved. |
| first_indexed | 2024-12-13T16:01:54Z |
| format | Article |
| id | doaj.art-195d660c5d9c4b958c577bebd6f5b073 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-13T16:01:54Z |
| publishDate | 2018-09-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-195d660c5d9c4b958c577bebd6f5b0732022-12-21T23:39:08ZengNature PortfolioNature Communications2041-17232018-09-019111310.1038/s41467-018-06196-zStructural determinants of Rab11 activation by the guanine nucleotide exchange factor SH3BP5Meredith L. Jenkins0Jean Piero Margaria1Jordan T. B. Stariha2Reece M. Hoffmann3Jacob A. McPhail4David J. Hamelin5Martin J. Boulanger6Emilio Hirsch7John E. Burke8Department of Biochemistry and Microbiology, University of VictoriaDepartment of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center, University of TurinDepartment of Biochemistry and Microbiology, University of VictoriaDepartment of Biochemistry and Microbiology, University of VictoriaDepartment of Biochemistry and Microbiology, University of VictoriaDepartment of Biochemistry and Microbiology, University of VictoriaDepartment of Biochemistry and Microbiology, University of VictoriaDepartment of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center, University of TurinDepartment of Biochemistry and Microbiology, University of VictoriaRab11 GTPases are involved in various cellular processes but their activation by guanine nucleotide exchange factors (GEFs) is not fully understood. Here, the authors present a structural and biochemical analysis of Rab11 bound to the GEF SH3BP5, providing insights how Rab-GEF specificity is achieved.https://doi.org/10.1038/s41467-018-06196-z |
| spellingShingle | Meredith L. Jenkins Jean Piero Margaria Jordan T. B. Stariha Reece M. Hoffmann Jacob A. McPhail David J. Hamelin Martin J. Boulanger Emilio Hirsch John E. Burke Structural determinants of Rab11 activation by the guanine nucleotide exchange factor SH3BP5 Nature Communications |
| title | Structural determinants of Rab11 activation by the guanine nucleotide exchange factor SH3BP5 |
| title_full | Structural determinants of Rab11 activation by the guanine nucleotide exchange factor SH3BP5 |
| title_fullStr | Structural determinants of Rab11 activation by the guanine nucleotide exchange factor SH3BP5 |
| title_full_unstemmed | Structural determinants of Rab11 activation by the guanine nucleotide exchange factor SH3BP5 |
| title_short | Structural determinants of Rab11 activation by the guanine nucleotide exchange factor SH3BP5 |
| title_sort | structural determinants of rab11 activation by the guanine nucleotide exchange factor sh3bp5 |
| url | https://doi.org/10.1038/s41467-018-06196-z |
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