Two‐Pore K+ Channel TREK‐1 Regulates Sinoatrial Node Membrane Excitability

Two‐Pore K+ Channel TREK‐1 Regulates Sinoatrial Node Membrane Excitability

BackgroundTwo‐pore K+ channels have emerged as potential targets to selectively regulate cardiac cell membrane excitability; however, lack of specific inhibitors and relevant animal models has impeded the effort to understand the role of 2‐pore K+ channels in the heart and their potential as a thera...

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Bibliographic Details
Main Authors: Sathya D. Unudurthi, Xiangqiong Wu, Lan Qian, Foued Amari, Birce Onal, Ning Li, Michael A. Makara, Sakima A. Smith, Jedidiah Snyder, Vadim V. Fedorov, Vincenzo Coppola, Mark E. Anderson, Peter J. Mohler, Thomas J. Hund
Format: Article
Language:English
Published: Wiley 2016-04-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
automaticity
K channel
sinoatrial node
spectrin
TREK‐1
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.115.002865

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