Host-directed therapy with 2-deoxy-D-glucose inhibits human rhinoviruses, endemic coronaviruses, and SARS-CoV-2

Host-directed therapy with 2-deoxy-D-glucose inhibits human rhinoviruses, endemic coronaviruses, and SARS-CoV-2

Rhinoviruses (RVs) and coronaviruses (CoVs) upregulate host cell metabolic pathways such as glycolysis to meet their bioenergetic demands for rapid multiplication. Using the glycolysis inhibitor 2-deoxy-d-glucose (2-DG), we assessed the dose-dependent inhibition of viral replication of minor- and ma...

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Bibliographic Details
Main Authors: Laxmikant Wali, Michael Karbiener, Scharon Chou, Vitalii Kovtunyk, Adam Adonyi, Irene Gösler, Ximena Contreras, Delyana Stoeva, Dieter Blaas, Johannes Stöckl, Thomas R. Kreil, Guido A. Gualdoni, Anna-Dorothea Gorki
Format: Article
Language:English
Published: Elsevier 2022-12-01
Series:Journal of Virus Eradication
Subjects:
Antiviral
Broad-spectrum antiviral therapy
2-DG
Rhinovirus
Coronavirus
SARS-CoV-2
Online Access:http://www.sciencedirect.com/science/article/pii/S2055664022002436

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http://www.sciencedirect.com/science/article/pii/S2055664022002436

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