Non-High-Density Lipoprotein Cholesterol and Progression of Chronic Kidney Disease: Results from the KNOW-CKD Study
As the relation between serum non-high-density lipoprotein cholesterol (nHDL) level and renal outcomes has never been investigated in patients with non-dialysis chronic kidney disease (CKD) yet, we here aimed to unveil the association of nHDL with CKD progression. A total of 2152 patients with non-d...
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MDPI AG
2022-11-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/14/21/4704 |
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| author | Sang Heon Suh Tae Ryom Oh Hong Sang Choi Chang Seong Kim Eun Hui Bae Seong Kwon Ma Kook-Hwan Oh Young Youl Hyun Suah Sung Soo Wan Kim |
| author_facet | Sang Heon Suh Tae Ryom Oh Hong Sang Choi Chang Seong Kim Eun Hui Bae Seong Kwon Ma Kook-Hwan Oh Young Youl Hyun Suah Sung Soo Wan Kim |
| author_sort | Sang Heon Suh |
| collection | DOAJ |
| description | As the relation between serum non-high-density lipoprotein cholesterol (nHDL) level and renal outcomes has never been investigated in patients with non-dialysis chronic kidney disease (CKD) yet, we here aimed to unveil the association of nHDL with CKD progression. A total of 2152 patients with non-dialysis CKD at stages 1 to 5 from the KNOW-CKD study were categorized into the tertile (i.e., 1st (T1), 2nd (T2), and 3rd (T3) tertiles) by nHDL, and were prospectively analyzed. The primary outcome was the composite renal event, defined as a composite of decline of kidney function or onset of end-stage renal disease. Kaplan–Meier survival curves analysis demonstrated that the cumulative incidence of the composite renal event was significantly increased in T1 and T3, compared to T2 (<i>p</i> = 0.028, by Log-rank test). Cox regression analysis revealed that both T1 (adjusted hazard ratio 1.309, 95% confidence interval 1.074–1.595) and T3 (adjusted hazard ratio 1.272, 95% confidence interval 1.040–1.556) are associated with significantly increased risk of a composite renal event, compared to T2. The restricted cubic spline plot demonstrated a non-linear, U-shaped association between nHDL and the risk of a composite renal event. In conclusion, both low and high serum nHDL levels are associated with increased risk of CKD progression. |
| first_indexed | 2024-03-09T18:45:44Z |
| format | Article |
| id | doaj.art-195f60da6d8f4a5fa01d96c4da97c9ca |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-09T18:45:44Z |
| publishDate | 2022-11-01 |
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| series | Nutrients |
| spelling | doaj.art-195f60da6d8f4a5fa01d96c4da97c9ca2023-11-24T06:15:56ZengMDPI AGNutrients2072-66432022-11-011421470410.3390/nu14214704Non-High-Density Lipoprotein Cholesterol and Progression of Chronic Kidney Disease: Results from the KNOW-CKD StudySang Heon Suh0Tae Ryom Oh1Hong Sang Choi2Chang Seong Kim3Eun Hui Bae4Seong Kwon Ma5Kook-Hwan Oh6Young Youl Hyun7Suah Sung8Soo Wan Kim9Department of Internal Medicine, Chonnam National University Medical School and Chonnam National University Hospital, Gwangju 61469, KoreaDepartment of Internal Medicine, Chonnam National University Medical School and Chonnam National University Hospital, Gwangju 61469, KoreaDepartment of Internal Medicine, Chonnam National University Medical School and Chonnam National University Hospital, Gwangju 61469, KoreaDepartment of Internal Medicine, Chonnam National University Medical School and Chonnam National University Hospital, Gwangju 61469, KoreaDepartment of Internal Medicine, Chonnam National University Medical School and Chonnam National University Hospital, Gwangju 61469, KoreaDepartment of Internal Medicine, Chonnam National University Medical School and Chonnam National University Hospital, Gwangju 61469, KoreaDepartment of Internal Medicine, Seoul National University Hospital, Seoul 03080, KoreaDepartment of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul 03181, KoreaDepartment of Internal Medicine, Eulji Medical Center, Eulji University, Seoul 01830, KoreaDepartment of Internal Medicine, Chonnam National University Medical School and Chonnam National University Hospital, Gwangju 61469, KoreaAs the relation between serum non-high-density lipoprotein cholesterol (nHDL) level and renal outcomes has never been investigated in patients with non-dialysis chronic kidney disease (CKD) yet, we here aimed to unveil the association of nHDL with CKD progression. A total of 2152 patients with non-dialysis CKD at stages 1 to 5 from the KNOW-CKD study were categorized into the tertile (i.e., 1st (T1), 2nd (T2), and 3rd (T3) tertiles) by nHDL, and were prospectively analyzed. The primary outcome was the composite renal event, defined as a composite of decline of kidney function or onset of end-stage renal disease. Kaplan–Meier survival curves analysis demonstrated that the cumulative incidence of the composite renal event was significantly increased in T1 and T3, compared to T2 (<i>p</i> = 0.028, by Log-rank test). Cox regression analysis revealed that both T1 (adjusted hazard ratio 1.309, 95% confidence interval 1.074–1.595) and T3 (adjusted hazard ratio 1.272, 95% confidence interval 1.040–1.556) are associated with significantly increased risk of a composite renal event, compared to T2. The restricted cubic spline plot demonstrated a non-linear, U-shaped association between nHDL and the risk of a composite renal event. In conclusion, both low and high serum nHDL levels are associated with increased risk of CKD progression.https://www.mdpi.com/2072-6643/14/21/4704chronic kidney diseaseestimated glomerular filtration ratenon-high-density lipoprotein cholesterolrenal outcome |
| spellingShingle | Sang Heon Suh Tae Ryom Oh Hong Sang Choi Chang Seong Kim Eun Hui Bae Seong Kwon Ma Kook-Hwan Oh Young Youl Hyun Suah Sung Soo Wan Kim Non-High-Density Lipoprotein Cholesterol and Progression of Chronic Kidney Disease: Results from the KNOW-CKD Study Nutrients chronic kidney disease estimated glomerular filtration rate non-high-density lipoprotein cholesterol renal outcome |
| title | Non-High-Density Lipoprotein Cholesterol and Progression of Chronic Kidney Disease: Results from the KNOW-CKD Study |
| title_full | Non-High-Density Lipoprotein Cholesterol and Progression of Chronic Kidney Disease: Results from the KNOW-CKD Study |
| title_fullStr | Non-High-Density Lipoprotein Cholesterol and Progression of Chronic Kidney Disease: Results from the KNOW-CKD Study |
| title_full_unstemmed | Non-High-Density Lipoprotein Cholesterol and Progression of Chronic Kidney Disease: Results from the KNOW-CKD Study |
| title_short | Non-High-Density Lipoprotein Cholesterol and Progression of Chronic Kidney Disease: Results from the KNOW-CKD Study |
| title_sort | non high density lipoprotein cholesterol and progression of chronic kidney disease results from the know ckd study |
| topic | chronic kidney disease estimated glomerular filtration rate non-high-density lipoprotein cholesterol renal outcome |
| url | https://www.mdpi.com/2072-6643/14/21/4704 |
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