Ependymal Cilia: Physiology and Role in Hydrocephalus
Cerebrospinal fluid (CSF), a colorless liquid that generally circulates from the lateral ventricles to the third and fourth ventricles, provides essential nutrients for brain homeostasis and growth factors during development. As evidenced by an increasing corpus of research, CSF serves a range of im...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-07-01
|
| Series: | Frontiers in Molecular Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnmol.2022.927479/full |
| _version_ | 1811292647809089536 |
|---|---|
| author | Weiye Ji Weiye Ji Weiye Ji Weiye Ji Zhi Tang Yibing Chen Yibing Chen Yibing Chen Chuansen Wang Chuansen Wang Chuansen Wang Changwu Tan Changwu Tan Changwu Tan Junbo Liao Junbo Liao Junbo Liao Lei Tong Lei Tong Lei Tong Gelei Xiao Gelei Xiao Gelei Xiao |
| author_facet | Weiye Ji Weiye Ji Weiye Ji Weiye Ji Zhi Tang Yibing Chen Yibing Chen Yibing Chen Chuansen Wang Chuansen Wang Chuansen Wang Changwu Tan Changwu Tan Changwu Tan Junbo Liao Junbo Liao Junbo Liao Lei Tong Lei Tong Lei Tong Gelei Xiao Gelei Xiao Gelei Xiao |
| author_sort | Weiye Ji |
| collection | DOAJ |
| description | Cerebrospinal fluid (CSF), a colorless liquid that generally circulates from the lateral ventricles to the third and fourth ventricles, provides essential nutrients for brain homeostasis and growth factors during development. As evidenced by an increasing corpus of research, CSF serves a range of important functions. While it is considered that decreased CSF flow is associated to the development of hydrocephalus, it has recently been postulated that motile cilia, which line the apical surfaces of ependymal cells (ECs), play a role in stimulating CSF circulation by cilia beating. Ependymal cilia protrude from ECs, and their synchronous pulsing transports CSF from the lateral ventricle to the third and fourth ventricles, and then to the subarachnoid cavity for absorption. As a result, we postulated that malfunctioning ependymal cilia could disrupt normal CSF flow, raising the risk of hydrocephalus. This review aims to demonstrate the physiological functions of ependymal cilia, as well as how cilia immobility or disorientation causes problems. We also conclude conceivable ways of treatment of hydrocephalus currently for clinical application and provide theoretical support for regimen improvements by investigating the relationship between ependymal cilia and hydrocephalus development. |
| first_indexed | 2024-04-13T04:48:29Z |
| format | Article |
| id | doaj.art-195fa33c2ddc4f2b987df3db1958f67d |
| institution | Directory Open Access Journal |
| issn | 1662-5099 |
| language | English |
| last_indexed | 2024-04-13T04:48:29Z |
| publishDate | 2022-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Molecular Neuroscience |
| spelling | doaj.art-195fa33c2ddc4f2b987df3db1958f67d2022-12-22T03:01:46ZengFrontiers Media S.A.Frontiers in Molecular Neuroscience1662-50992022-07-011510.3389/fnmol.2022.927479927479Ependymal Cilia: Physiology and Role in HydrocephalusWeiye Ji0Weiye Ji1Weiye Ji2Weiye Ji3Zhi Tang4Yibing Chen5Yibing Chen6Yibing Chen7Chuansen Wang8Chuansen Wang9Chuansen Wang10Changwu Tan11Changwu Tan12Changwu Tan13Junbo Liao14Junbo Liao15Junbo Liao16Lei Tong17Lei Tong18Lei Tong19Gelei Xiao20Gelei Xiao21Gelei Xiao22Department of Neurosurgery, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, ChinaDepartment of Neurosurgery, Xiangya Hospital, Central South University, Changsha, ChinaDiagnosis and Treatment Center for Hydrocephalus, Xiangya Hospital, Central South University, Changsha, ChinaNational Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Neurosurgery, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, ChinaDepartment of Neurosurgery, Xiangya Hospital, Central South University, Changsha, ChinaDiagnosis and Treatment Center for Hydrocephalus, Xiangya Hospital, Central South University, Changsha, ChinaNational Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Neurosurgery, Xiangya Hospital, Central South University, Changsha, ChinaDiagnosis and Treatment Center for Hydrocephalus, Xiangya Hospital, Central South University, Changsha, ChinaNational Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Neurosurgery, Xiangya Hospital, Central South University, Changsha, ChinaDiagnosis and Treatment Center for Hydrocephalus, Xiangya Hospital, Central South University, Changsha, ChinaNational Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Neurosurgery, Xiangya Hospital, Central South University, Changsha, ChinaDiagnosis and Treatment Center for Hydrocephalus, Xiangya Hospital, Central South University, Changsha, ChinaNational Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Neurosurgery, Xiangya Hospital, Central South University, Changsha, ChinaDiagnosis and Treatment Center for Hydrocephalus, Xiangya Hospital, Central South University, Changsha, ChinaNational Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Neurosurgery, Xiangya Hospital, Central South University, Changsha, ChinaDiagnosis and Treatment Center for Hydrocephalus, Xiangya Hospital, Central South University, Changsha, ChinaNational Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, ChinaCerebrospinal fluid (CSF), a colorless liquid that generally circulates from the lateral ventricles to the third and fourth ventricles, provides essential nutrients for brain homeostasis and growth factors during development. As evidenced by an increasing corpus of research, CSF serves a range of important functions. While it is considered that decreased CSF flow is associated to the development of hydrocephalus, it has recently been postulated that motile cilia, which line the apical surfaces of ependymal cells (ECs), play a role in stimulating CSF circulation by cilia beating. Ependymal cilia protrude from ECs, and their synchronous pulsing transports CSF from the lateral ventricle to the third and fourth ventricles, and then to the subarachnoid cavity for absorption. As a result, we postulated that malfunctioning ependymal cilia could disrupt normal CSF flow, raising the risk of hydrocephalus. This review aims to demonstrate the physiological functions of ependymal cilia, as well as how cilia immobility or disorientation causes problems. We also conclude conceivable ways of treatment of hydrocephalus currently for clinical application and provide theoretical support for regimen improvements by investigating the relationship between ependymal cilia and hydrocephalus development.https://www.frontiersin.org/articles/10.3389/fnmol.2022.927479/fullependymal ciliahydrocephaluscerebrospinal fluidpathogenesistreatment |
| spellingShingle | Weiye Ji Weiye Ji Weiye Ji Weiye Ji Zhi Tang Yibing Chen Yibing Chen Yibing Chen Chuansen Wang Chuansen Wang Chuansen Wang Changwu Tan Changwu Tan Changwu Tan Junbo Liao Junbo Liao Junbo Liao Lei Tong Lei Tong Lei Tong Gelei Xiao Gelei Xiao Gelei Xiao Ependymal Cilia: Physiology and Role in Hydrocephalus Frontiers in Molecular Neuroscience ependymal cilia hydrocephalus cerebrospinal fluid pathogenesis treatment |
| title | Ependymal Cilia: Physiology and Role in Hydrocephalus |
| title_full | Ependymal Cilia: Physiology and Role in Hydrocephalus |
| title_fullStr | Ependymal Cilia: Physiology and Role in Hydrocephalus |
| title_full_unstemmed | Ependymal Cilia: Physiology and Role in Hydrocephalus |
| title_short | Ependymal Cilia: Physiology and Role in Hydrocephalus |
| title_sort | ependymal cilia physiology and role in hydrocephalus |
| topic | ependymal cilia hydrocephalus cerebrospinal fluid pathogenesis treatment |
| url | https://www.frontiersin.org/articles/10.3389/fnmol.2022.927479/full |
| work_keys_str_mv | AT weiyeji ependymalciliaphysiologyandroleinhydrocephalus AT weiyeji ependymalciliaphysiologyandroleinhydrocephalus AT weiyeji ependymalciliaphysiologyandroleinhydrocephalus AT weiyeji ependymalciliaphysiologyandroleinhydrocephalus AT zhitang ependymalciliaphysiologyandroleinhydrocephalus AT yibingchen ependymalciliaphysiologyandroleinhydrocephalus AT yibingchen ependymalciliaphysiologyandroleinhydrocephalus AT yibingchen ependymalciliaphysiologyandroleinhydrocephalus AT chuansenwang ependymalciliaphysiologyandroleinhydrocephalus AT chuansenwang ependymalciliaphysiologyandroleinhydrocephalus AT chuansenwang ependymalciliaphysiologyandroleinhydrocephalus AT changwutan ependymalciliaphysiologyandroleinhydrocephalus AT changwutan ependymalciliaphysiologyandroleinhydrocephalus AT changwutan ependymalciliaphysiologyandroleinhydrocephalus AT junboliao ependymalciliaphysiologyandroleinhydrocephalus AT junboliao ependymalciliaphysiologyandroleinhydrocephalus AT junboliao ependymalciliaphysiologyandroleinhydrocephalus AT leitong ependymalciliaphysiologyandroleinhydrocephalus AT leitong ependymalciliaphysiologyandroleinhydrocephalus AT leitong ependymalciliaphysiologyandroleinhydrocephalus AT geleixiao ependymalciliaphysiologyandroleinhydrocephalus AT geleixiao ependymalciliaphysiologyandroleinhydrocephalus AT geleixiao ependymalciliaphysiologyandroleinhydrocephalus |