Resting-State Functional MRI Study: Connection Strength of Brain Networks in DR Patients
Lan Li,1 Hui Dai,2 Jun Ke,2 Cen Shi,2 Nan Jiang,2 Chun-Mei Yang3 1Department of Endocrinology, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 215006, People’s Republic of China; 2Department of Radiology, First Affiliated Hospital of Soochow University, Suzhou, Jia...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Dove Medical Press
2019-12-01
|
| Series: | Neuropsychiatric Disease and Treatment |
| Subjects: | |
| Online Access: | https://www.dovepress.com/resting-state-functional-mri-study-connection-strength-of-brain-networ-peer-reviewed-article-NDT |
| _version_ | 1818422187590156288 |
|---|---|
| author | Li L Dai H Ke J Shi C Jiang N Yang CM |
| author_facet | Li L Dai H Ke J Shi C Jiang N Yang CM |
| author_sort | Li L |
| collection | DOAJ |
| description | Lan Li,1 Hui Dai,2 Jun Ke,2 Cen Shi,2 Nan Jiang,2 Chun-Mei Yang3 1Department of Endocrinology, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 215006, People’s Republic of China; 2Department of Radiology, First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, People’s Republic of China; 3Department of Endocrinology, First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, People’s Republic of ChinaCorrespondence: Hui DaiDepartment of Radiology, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, People’s Republic of ChinaTel/Fax +86512-67780633Email huizi198208@126.comChun-Mei YangDepartment of Endocrinology, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, People’s Republic of ChinaTel/Fax +86512-67780633Email muyi1979yang@163.comPurpose: To explore the functional connection strength (FCS) changes of brain networks in diabetic retinopathy (DR) patients and uncover the underlying mechanism.Methods and Materials: Twenty-one patients with DR and 21 age- and sex-matched healthy controls were enrolled from August 2012 to September 2014. Subjects were scanned using 3T MR with blood-oxygen-level dependent (BOLD) and 3-dimension fast spoiled gradient echo (3D-FSPGR) sequences. MR data was analyzed via preprocessing and functional network construction. After a group comparison, components of brain networks with significant group differences were extracted and the FCS of the brain network was evaluated. The brain areas were compared between patients and controls. P-values less than 0.05 were considered statistically significant. Connection strength was evaluated with alphasim, P<0.01.Results: The component maps of altered brain networks with quantified FCS were obtained in DR patients, demonstrating more disconnections mainly in the bilateral Heschl’s gyrus, left cuneus, left occipital lobe, bilateral amygdala, left parahippocampal, bilateral fusiform, and left superior parietal in the patients group compared to the healthy controls (P<0.01), while compensations may occur in the frontal-cingulum region, as well as among the right caudate, left thalamus, left inferior temporal lobe, and middle orbital frontal lobe.Conclusion: Brain network connections, decreased in the brain areas of which in charging with cognition and visual function, suggests that DR patients might have cognitive decline and visual function loss. However, there might be a frontal compensatory circle in patients with DR.Keywords: resting-state functional MRI, brain networks, functional connection strength, diabetic retinopathy |
| first_indexed | 2024-12-14T13:22:16Z |
| format | Article |
| id | doaj.art-19616f4404e44e1ab418e0b7c2c1fec1 |
| institution | Directory Open Access Journal |
| issn | 1178-2021 |
| language | English |
| last_indexed | 2024-12-14T13:22:16Z |
| publishDate | 2019-12-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Neuropsychiatric Disease and Treatment |
| spelling | doaj.art-19616f4404e44e1ab418e0b7c2c1fec12022-12-21T22:59:54ZengDove Medical PressNeuropsychiatric Disease and Treatment1178-20212019-12-01Volume 153359336650256Resting-State Functional MRI Study: Connection Strength of Brain Networks in DR PatientsLi LDai HKe JShi CJiang NYang CMLan Li,1 Hui Dai,2 Jun Ke,2 Cen Shi,2 Nan Jiang,2 Chun-Mei Yang3 1Department of Endocrinology, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 215006, People’s Republic of China; 2Department of Radiology, First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, People’s Republic of China; 3Department of Endocrinology, First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, People’s Republic of ChinaCorrespondence: Hui DaiDepartment of Radiology, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, People’s Republic of ChinaTel/Fax +86512-67780633Email huizi198208@126.comChun-Mei YangDepartment of Endocrinology, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, People’s Republic of ChinaTel/Fax +86512-67780633Email muyi1979yang@163.comPurpose: To explore the functional connection strength (FCS) changes of brain networks in diabetic retinopathy (DR) patients and uncover the underlying mechanism.Methods and Materials: Twenty-one patients with DR and 21 age- and sex-matched healthy controls were enrolled from August 2012 to September 2014. Subjects were scanned using 3T MR with blood-oxygen-level dependent (BOLD) and 3-dimension fast spoiled gradient echo (3D-FSPGR) sequences. MR data was analyzed via preprocessing and functional network construction. After a group comparison, components of brain networks with significant group differences were extracted and the FCS of the brain network was evaluated. The brain areas were compared between patients and controls. P-values less than 0.05 were considered statistically significant. Connection strength was evaluated with alphasim, P<0.01.Results: The component maps of altered brain networks with quantified FCS were obtained in DR patients, demonstrating more disconnections mainly in the bilateral Heschl’s gyrus, left cuneus, left occipital lobe, bilateral amygdala, left parahippocampal, bilateral fusiform, and left superior parietal in the patients group compared to the healthy controls (P<0.01), while compensations may occur in the frontal-cingulum region, as well as among the right caudate, left thalamus, left inferior temporal lobe, and middle orbital frontal lobe.Conclusion: Brain network connections, decreased in the brain areas of which in charging with cognition and visual function, suggests that DR patients might have cognitive decline and visual function loss. However, there might be a frontal compensatory circle in patients with DR.Keywords: resting-state functional MRI, brain networks, functional connection strength, diabetic retinopathyhttps://www.dovepress.com/resting-state-functional-mri-study-connection-strength-of-brain-networ-peer-reviewed-article-NDTresting-state functional mribrain networksfunctional connection strengthdiabetic retinopathy |
| spellingShingle | Li L Dai H Ke J Shi C Jiang N Yang CM Resting-State Functional MRI Study: Connection Strength of Brain Networks in DR Patients Neuropsychiatric Disease and Treatment resting-state functional mri brain networks functional connection strength diabetic retinopathy |
| title | Resting-State Functional MRI Study: Connection Strength of Brain Networks in DR Patients |
| title_full | Resting-State Functional MRI Study: Connection Strength of Brain Networks in DR Patients |
| title_fullStr | Resting-State Functional MRI Study: Connection Strength of Brain Networks in DR Patients |
| title_full_unstemmed | Resting-State Functional MRI Study: Connection Strength of Brain Networks in DR Patients |
| title_short | Resting-State Functional MRI Study: Connection Strength of Brain Networks in DR Patients |
| title_sort | resting state functional mri study connection strength of brain networks in dr patients |
| topic | resting-state functional mri brain networks functional connection strength diabetic retinopathy |
| url | https://www.dovepress.com/resting-state-functional-mri-study-connection-strength-of-brain-networ-peer-reviewed-article-NDT |
| work_keys_str_mv | AT lil restingstatefunctionalmristudyconnectionstrengthofbrainnetworksindrpatients AT daih restingstatefunctionalmristudyconnectionstrengthofbrainnetworksindrpatients AT kej restingstatefunctionalmristudyconnectionstrengthofbrainnetworksindrpatients AT shic restingstatefunctionalmristudyconnectionstrengthofbrainnetworksindrpatients AT jiangn restingstatefunctionalmristudyconnectionstrengthofbrainnetworksindrpatients AT yangcm restingstatefunctionalmristudyconnectionstrengthofbrainnetworksindrpatients |