Valsartan and candesartan can inhibit deteriorating effects of angiotensin II on coronary endothelial function
The angiotensin II (Ang II) AT 1 -receptor antagonists, valsartan and candesartan, were compared with regard to their effect on Ang II-mediated changes in parameters of coronary endothelial function. Ang II (10 µM) induced increased concentrations of the vasoconstrictor endothelin, the procoagulator...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publications
2001-06-01
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| Series: | Journal of the Renin-Angiotensin-Aldosterone System |
| Online Access: | https://doi.org/10.3317/jraas.2001.016 |
| _version_ | 1797282063283388416 |
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| author | Harald Seeger Caroline Lippert Diethelm Wallwiener Alfred O Mueck |
| author_facet | Harald Seeger Caroline Lippert Diethelm Wallwiener Alfred O Mueck |
| author_sort | Harald Seeger |
| collection | DOAJ |
| description | The angiotensin II (Ang II) AT 1 -receptor antagonists, valsartan and candesartan, were compared with regard to their effect on Ang II-mediated changes in parameters of coronary endothelial function. Ang II (10 µM) induced increased concentrations of the vasoconstrictor endothelin, the procoagulatory substance plasminogen-activator-inhibitor-1 (PAI-1) and the precursor of the matrix-metalloproteinase 1 (MMP-1) in endothelial cell cultures from human coronary arteries. These increases were completely prevented by the addition of 10 µM valsartan or candesartan and partially by the addition of lower concentrations of these drugs, i.e. 1 µM and 0.1 µM. No significant difference between the effect of the two AT 1 -receptor antagonists was observed. These results suggest that AT 1 -receptor antagonists not only can reduce blood pressure by blocking the action of Ang II, but might also contribute to the prevention of atherogenesis and plaque instability. |
| first_indexed | 2024-03-07T17:06:32Z |
| format | Article |
| id | doaj.art-19624f5437da433babf4aae02923c166 |
| institution | Directory Open Access Journal |
| issn | 1470-3203 |
| language | English |
| last_indexed | 2024-03-07T17:06:32Z |
| publishDate | 2001-06-01 |
| publisher | SAGE Publications |
| record_format | Article |
| series | Journal of the Renin-Angiotensin-Aldosterone System |
| spelling | doaj.art-19624f5437da433babf4aae02923c1662024-03-03T02:33:03ZengSAGE PublicationsJournal of the Renin-Angiotensin-Aldosterone System1470-32032001-06-01210.3317/jraas.2001.016Valsartan and candesartan can inhibit deteriorating effects of angiotensin II on coronary endothelial functionHarald SeegerCaroline LippertDiethelm WallwienerAlfred O MueckThe angiotensin II (Ang II) AT 1 -receptor antagonists, valsartan and candesartan, were compared with regard to their effect on Ang II-mediated changes in parameters of coronary endothelial function. Ang II (10 µM) induced increased concentrations of the vasoconstrictor endothelin, the procoagulatory substance plasminogen-activator-inhibitor-1 (PAI-1) and the precursor of the matrix-metalloproteinase 1 (MMP-1) in endothelial cell cultures from human coronary arteries. These increases were completely prevented by the addition of 10 µM valsartan or candesartan and partially by the addition of lower concentrations of these drugs, i.e. 1 µM and 0.1 µM. No significant difference between the effect of the two AT 1 -receptor antagonists was observed. These results suggest that AT 1 -receptor antagonists not only can reduce blood pressure by blocking the action of Ang II, but might also contribute to the prevention of atherogenesis and plaque instability.https://doi.org/10.3317/jraas.2001.016 |
| spellingShingle | Harald Seeger Caroline Lippert Diethelm Wallwiener Alfred O Mueck Valsartan and candesartan can inhibit deteriorating effects of angiotensin II on coronary endothelial function Journal of the Renin-Angiotensin-Aldosterone System |
| title | Valsartan and candesartan can inhibit deteriorating effects of angiotensin II on coronary endothelial function |
| title_full | Valsartan and candesartan can inhibit deteriorating effects of angiotensin II on coronary endothelial function |
| title_fullStr | Valsartan and candesartan can inhibit deteriorating effects of angiotensin II on coronary endothelial function |
| title_full_unstemmed | Valsartan and candesartan can inhibit deteriorating effects of angiotensin II on coronary endothelial function |
| title_short | Valsartan and candesartan can inhibit deteriorating effects of angiotensin II on coronary endothelial function |
| title_sort | valsartan and candesartan can inhibit deteriorating effects of angiotensin ii on coronary endothelial function |
| url | https://doi.org/10.3317/jraas.2001.016 |
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