Extremely preterm children demonstrate hyperconnectivity during verb generation: A multimodal approach
Children born extremely preterm (EPT, <28 weeks gestation) are at risk for delays in development, including language. We use fMRI-constrained magnetoencephalography (MEG) during a verb generation task to assess the extent and functional connectivity (phase locking value, or PLV) of language netwo...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2021-01-01
|
| Series: | NeuroImage: Clinical |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213158221000334 |
| _version_ | 1818661786546601984 |
|---|---|
| author | Maria E. Barnes-Davis Stephanie L. Merhar Scott K. Holland Nehal A. Parikh Darren S. Kadis |
| author_facet | Maria E. Barnes-Davis Stephanie L. Merhar Scott K. Holland Nehal A. Parikh Darren S. Kadis |
| author_sort | Maria E. Barnes-Davis |
| collection | DOAJ |
| description | Children born extremely preterm (EPT, <28 weeks gestation) are at risk for delays in development, including language. We use fMRI-constrained magnetoencephalography (MEG) during a verb generation task to assess the extent and functional connectivity (phase locking value, or PLV) of language networks in a large cohort of EPT children and their term comparisons (TC). 73 participants, aged 4 to 6 years, were enrolled (42 TC, 31 EPT). There were no significant group differences in age, sex, race, ethnicity, parental education, or family income. There were significant group differences in expressive language scores (p < 0.05). Language representation was not significantly different between groups on fMRI, with task-specific activation involving bilateral temporal and left inferior frontal cortex. There were group differences in functional connectivity seen in MEG. To identify a possible subnetwork contributing to focal spectral differences in connectivity, we ran Network Based Statistics analyses. For both beta (20–25 Hz) and gamma (61–70 Hz) bands, we observed a subnetwork showing hyperconnectivity in the EPT group (p < 0.05). Network strength was computed for the beta and gamma subnetworks and assessed for correlation with language performance. For the EPT group exclusively, strength of the subnetwork identified in the gamma frequency band was positively correlated with expressive language scores (r = 0.318, p < 0.05). Thus, hyperconnectivity is positively related to language for EPT children and might represent a marker for resiliency in this population. |
| first_indexed | 2024-12-17T04:50:36Z |
| format | Article |
| id | doaj.art-19625c050289483389e405d36bf4dd53 |
| institution | Directory Open Access Journal |
| issn | 2213-1582 |
| language | English |
| last_indexed | 2024-12-17T04:50:36Z |
| publishDate | 2021-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage: Clinical |
| spelling | doaj.art-19625c050289483389e405d36bf4dd532022-12-21T22:02:55ZengElsevierNeuroImage: Clinical2213-15822021-01-0130102589Extremely preterm children demonstrate hyperconnectivity during verb generation: A multimodal approachMaria E. Barnes-Davis0Stephanie L. Merhar1Scott K. Holland2Nehal A. Parikh3Darren S. Kadis4Cincinnati Children’s Hospital Medical Center, Perinatal Institute, United States; University of Cincinnati, Department of Pediatrics, United States; University of Cincinnati, Department of Neuroscience, United States; Corresponding author at: Department of Pediatrics, University of Cincinnati College of Medicine, Attending Neonatologist, Perinatal Institute, Cincinnati Children's Hospital Medical Center, United States.Cincinnati Children’s Hospital Medical Center, Perinatal Institute, United States; University of Cincinnati, Department of Pediatrics, United StatesMedpace Imaging Core Laboratory, Medpace Inc., United States; University of Cincinnati, Department of Physics, United StatesCincinnati Children’s Hospital Medical Center, Perinatal Institute, United States; University of Cincinnati, Department of Pediatrics, United StatesHospital for Sick Children and University of Toronto are in Toronto, Canada; University of Toronto, Department of Physiology, CanadaChildren born extremely preterm (EPT, <28 weeks gestation) are at risk for delays in development, including language. We use fMRI-constrained magnetoencephalography (MEG) during a verb generation task to assess the extent and functional connectivity (phase locking value, or PLV) of language networks in a large cohort of EPT children and their term comparisons (TC). 73 participants, aged 4 to 6 years, were enrolled (42 TC, 31 EPT). There were no significant group differences in age, sex, race, ethnicity, parental education, or family income. There were significant group differences in expressive language scores (p < 0.05). Language representation was not significantly different between groups on fMRI, with task-specific activation involving bilateral temporal and left inferior frontal cortex. There were group differences in functional connectivity seen in MEG. To identify a possible subnetwork contributing to focal spectral differences in connectivity, we ran Network Based Statistics analyses. For both beta (20–25 Hz) and gamma (61–70 Hz) bands, we observed a subnetwork showing hyperconnectivity in the EPT group (p < 0.05). Network strength was computed for the beta and gamma subnetworks and assessed for correlation with language performance. For the EPT group exclusively, strength of the subnetwork identified in the gamma frequency band was positively correlated with expressive language scores (r = 0.318, p < 0.05). Thus, hyperconnectivity is positively related to language for EPT children and might represent a marker for resiliency in this population.http://www.sciencedirect.com/science/article/pii/S2213158221000334PrematurityLanguageFunctional MRIMagnetoencephalographyConnectivity |
| spellingShingle | Maria E. Barnes-Davis Stephanie L. Merhar Scott K. Holland Nehal A. Parikh Darren S. Kadis Extremely preterm children demonstrate hyperconnectivity during verb generation: A multimodal approach NeuroImage: Clinical Prematurity Language Functional MRI Magnetoencephalography Connectivity |
| title | Extremely preterm children demonstrate hyperconnectivity during verb generation: A multimodal approach |
| title_full | Extremely preterm children demonstrate hyperconnectivity during verb generation: A multimodal approach |
| title_fullStr | Extremely preterm children demonstrate hyperconnectivity during verb generation: A multimodal approach |
| title_full_unstemmed | Extremely preterm children demonstrate hyperconnectivity during verb generation: A multimodal approach |
| title_short | Extremely preterm children demonstrate hyperconnectivity during verb generation: A multimodal approach |
| title_sort | extremely preterm children demonstrate hyperconnectivity during verb generation a multimodal approach |
| topic | Prematurity Language Functional MRI Magnetoencephalography Connectivity |
| url | http://www.sciencedirect.com/science/article/pii/S2213158221000334 |
| work_keys_str_mv | AT mariaebarnesdavis extremelypretermchildrendemonstratehyperconnectivityduringverbgenerationamultimodalapproach AT stephanielmerhar extremelypretermchildrendemonstratehyperconnectivityduringverbgenerationamultimodalapproach AT scottkholland extremelypretermchildrendemonstratehyperconnectivityduringverbgenerationamultimodalapproach AT nehalaparikh extremelypretermchildrendemonstratehyperconnectivityduringverbgenerationamultimodalapproach AT darrenskadis extremelypretermchildrendemonstratehyperconnectivityduringverbgenerationamultimodalapproach |