MRI and Pulmonary Function Tests’ Results as Ventilation Inhomogeneity Markers in Children and Adolescents with Cystic Fibrosis
Magnetic resonance imaging (MRI) of the chest is becoming more available in the detection and monitoring of early changes in lung function and structure in patients with cystic fibrosis (CF). The aim of this study was to assess the relationship between pulmonary function tests (PFT) and perfusion de...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-08-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/12/15/5136 |
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| author | Irena Wojsyk-Banaszak Barbara Więckowska Aleksandra Szczepankiewicz Zuzanna Stachowiak Marta Andrzejewska Jerzy Juchnowicz Maciej Kycler Paulina Famulska Marta Osińska Katarzyna Jończyk-Potoczna |
| author_facet | Irena Wojsyk-Banaszak Barbara Więckowska Aleksandra Szczepankiewicz Zuzanna Stachowiak Marta Andrzejewska Jerzy Juchnowicz Maciej Kycler Paulina Famulska Marta Osińska Katarzyna Jończyk-Potoczna |
| author_sort | Irena Wojsyk-Banaszak |
| collection | DOAJ |
| description | Magnetic resonance imaging (MRI) of the chest is becoming more available in the detection and monitoring of early changes in lung function and structure in patients with cystic fibrosis (CF). The aim of this study was to assess the relationship between pulmonary function tests (PFT) and perfusion deficits in CF children measured by MRI. We performed a retrospective analysis of the perfusion lung MRI scans and the results of spirometry, oscillometry, body plethysmography, single-breath carbon monoxide uptake, and multiple-breath washout technique (MBW). There were statistically significant correlations between the MRI perfusion scores and MBW parameters (2.5% LCI, M1/M0, M2/M0), spirometry parameters (FEV<sub>1</sub>, FVC, FEF25/75), reactance indices in impulse oscillometry (X5Hz, X10Hz), total lung capacity (TLC) measured in single breath carbon monoxide uptake, markers of air-trapping in body plethysmography (RV, RV/TLC), and the diffusing capacity of the lungs for carbon monoxide. We also observed significant differences in the aforementioned PFT variables between the patient groups divided based on perfusion scores. We noted a correlation between markers of functional lung deficits measured by the MRI and PFTs in CF children. MRI perfusion abnormalities were reflected sooner in the course of the disease than PFT abnormalities. |
| first_indexed | 2024-03-11T00:23:07Z |
| format | Article |
| id | doaj.art-19626bde38e5490f940d1b3287a4a014 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-11T00:23:07Z |
| publishDate | 2023-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-19626bde38e5490f940d1b3287a4a0142023-11-18T23:09:51ZengMDPI AGJournal of Clinical Medicine2077-03832023-08-011215513610.3390/jcm12155136MRI and Pulmonary Function Tests’ Results as Ventilation Inhomogeneity Markers in Children and Adolescents with Cystic FibrosisIrena Wojsyk-Banaszak0Barbara Więckowska1Aleksandra Szczepankiewicz2Zuzanna Stachowiak3Marta Andrzejewska4Jerzy Juchnowicz5Maciej Kycler6Paulina Famulska7Marta Osińska8Katarzyna Jończyk-Potoczna9Department of Paediatric Pulmonology, Allergy and Clinical Immunology, Poznan University of Medical Sciences, 60-572 Poznań, PolandDepartment of Computer Science and Statistics, Poznan University of Medical Sciences, 61-701 Poznań, PolandMolecular and Cell Biology Unit, Poznan University of Medical Sciences, 60-572 Poznań, PolandMolecular and Cell Biology Unit, Poznan University of Medical Sciences, 60-572 Poznań, PolandDepartment of Paediatric Pulmonology, Allergy and Clinical Immunology, Poznan University of Medical Sciences, 60-572 Poznań, PolandDepartment of Computer Science and Statistics, Poznan University of Medical Sciences, 61-701 Poznań, PolandDepartment of Paediatric Pulmonology, Allergy and Clinical Immunology, Poznan University of Medical Sciences, 60-572 Poznań, PolandPediatric and Cystic Fibrosis Department, Pediatric Hospital in Gdańsk, 80-308 Gdańsk, PolandPediatric and Cystic Fibrosis Department, Pediatric Hospital in Gdańsk, 80-308 Gdańsk, PolandDepartment of Paediatric Radiology, Poznan University of Medical Sciences, 61-701 Poznań, PolandMagnetic resonance imaging (MRI) of the chest is becoming more available in the detection and monitoring of early changes in lung function and structure in patients with cystic fibrosis (CF). The aim of this study was to assess the relationship between pulmonary function tests (PFT) and perfusion deficits in CF children measured by MRI. We performed a retrospective analysis of the perfusion lung MRI scans and the results of spirometry, oscillometry, body plethysmography, single-breath carbon monoxide uptake, and multiple-breath washout technique (MBW). There were statistically significant correlations between the MRI perfusion scores and MBW parameters (2.5% LCI, M1/M0, M2/M0), spirometry parameters (FEV<sub>1</sub>, FVC, FEF25/75), reactance indices in impulse oscillometry (X5Hz, X10Hz), total lung capacity (TLC) measured in single breath carbon monoxide uptake, markers of air-trapping in body plethysmography (RV, RV/TLC), and the diffusing capacity of the lungs for carbon monoxide. We also observed significant differences in the aforementioned PFT variables between the patient groups divided based on perfusion scores. We noted a correlation between markers of functional lung deficits measured by the MRI and PFTs in CF children. MRI perfusion abnormalities were reflected sooner in the course of the disease than PFT abnormalities.https://www.mdpi.com/2077-0383/12/15/5136cystic fibrosischildrenMRIpulmonary function tests |
| spellingShingle | Irena Wojsyk-Banaszak Barbara Więckowska Aleksandra Szczepankiewicz Zuzanna Stachowiak Marta Andrzejewska Jerzy Juchnowicz Maciej Kycler Paulina Famulska Marta Osińska Katarzyna Jończyk-Potoczna MRI and Pulmonary Function Tests’ Results as Ventilation Inhomogeneity Markers in Children and Adolescents with Cystic Fibrosis Journal of Clinical Medicine cystic fibrosis children MRI pulmonary function tests |
| title | MRI and Pulmonary Function Tests’ Results as Ventilation Inhomogeneity Markers in Children and Adolescents with Cystic Fibrosis |
| title_full | MRI and Pulmonary Function Tests’ Results as Ventilation Inhomogeneity Markers in Children and Adolescents with Cystic Fibrosis |
| title_fullStr | MRI and Pulmonary Function Tests’ Results as Ventilation Inhomogeneity Markers in Children and Adolescents with Cystic Fibrosis |
| title_full_unstemmed | MRI and Pulmonary Function Tests’ Results as Ventilation Inhomogeneity Markers in Children and Adolescents with Cystic Fibrosis |
| title_short | MRI and Pulmonary Function Tests’ Results as Ventilation Inhomogeneity Markers in Children and Adolescents with Cystic Fibrosis |
| title_sort | mri and pulmonary function tests results as ventilation inhomogeneity markers in children and adolescents with cystic fibrosis |
| topic | cystic fibrosis children MRI pulmonary function tests |
| url | https://www.mdpi.com/2077-0383/12/15/5136 |
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