Profibrotic, Electrical, and Calcium-Handling Remodeling of the Atria in Heart Failure Patients With and Without Atrial Fibrillation

Profibrotic, Electrical, and Calcium-Handling Remodeling of the Atria in Heart Failure Patients With and Without Atrial Fibrillation

Atrial fibrillation (AF) and heart failure (HF) are common cardiovascular diseases that often co-exist. Animal models have suggested complex AF-promoting atrial structural, electrical, and Ca2+-handling remodeling in the setting of HF, but data in human samples are scarce, particularly regarding Ca2...

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Bibliographic Details
Main Authors: Cristina E. Molina, Issam H. Abu-Taha, Qiongling Wang, Elena Roselló-Díez, Marcus Kamler, Stanley Nattel, Ursula Ravens, Xander H. T. Wehrens, Leif Hove-Madsen, Jordi Heijman, Dobromir Dobrev
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-10-01
Series:Frontiers in Physiology
Subjects:
atrial fibrillation
heart failure
heart failure with reduced ejection fraction
human atrial cardiomyocytes
Ca2+ handling
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2018.01383/full

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