Correlation between Folic Acid and Homocysteine Plasma in Severe Pre-Eclampsia and Normal Pregnancy
Background: Lack of folic acid intake or genetic abnormalities in folic acid metabolism was correlates with elevated plasma or serum homocysteine concentrations. This case-control analytical study aims to determine the correlation between folic acid and homocysteine levels in severe pre-eclampsia an...
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| Format: | Article |
| Language: | English |
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Universitas Indonesia
2018-08-01
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| Series: | Makara Journal of Health Research |
| Subjects: | |
| Online Access: | https://scholarhub.ui.ac.id/mjhr/vol22/iss2/4/ |
| _version_ | 1827990984739258368 |
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| author | Inke Malahayati Joserizal Serudji Delmi Sulastri |
| author_facet | Inke Malahayati Joserizal Serudji Delmi Sulastri |
| author_sort | Inke Malahayati |
| collection | DOAJ |
| description | Background: Lack of folic acid intake or genetic abnormalities in folic acid metabolism was correlates with elevated plasma or serum homocysteine concentrations. This case-control analytical study aims to determine the correlation between folic acid and homocysteine levels in severe pre-eclampsia and normal pregnancy. Methods: We enrolled 46 pregnant women (age 20─35 years) with severe pre-eclampsia or normal pregnancy at a government hospital in Padang, Indonesia, between March and May 2015. The samples size was selected by consecutive sampling. Then, we determined folic acid and homocysteine levels using ELISA and statistical analysis using the independent t-test and Pearson correlation. Results: We observed a difference in folic acid levels between severe pre-eclampsia (39.48 ± 9.40 ng/mL) and normal pregnancy (47.04 ± 13.20 ng/mL, p < 0.05). A difference was also observed in homocysteine levels between pre-eclampsia (18.52 ± 0.41 pmol/mL) and normal pregnancy (17.80 ± 0.73 pmol/mL, p < 0.05). The correlation between folic acid and homocysteine in severe pre-eclampsia and normal pregnancy was negative (r = -0.034, p > 0.05 and r = -0.222, p > 0.05, respectively). Conclusions: Low folic acid levels tend to increase homocysteine levels in severe pre-eclampsia, whereas high folic acid levels tend to lower homocysteine levels in normal pregnancy. |
| first_indexed | 2024-04-10T00:43:37Z |
| format | Article |
| id | doaj.art-196493a28cc24830b1f18ac6fd71cabc |
| institution | Directory Open Access Journal |
| issn | 2356-3664 2356-3656 |
| language | English |
| last_indexed | 2024-04-10T00:43:37Z |
| publishDate | 2018-08-01 |
| publisher | Universitas Indonesia |
| record_format | Article |
| series | Makara Journal of Health Research |
| spelling | doaj.art-196493a28cc24830b1f18ac6fd71cabc2023-03-14T04:22:45ZengUniversitas IndonesiaMakara Journal of Health Research2356-36642356-36562018-08-01222747910.7454/msk.v22i2.92973940Correlation between Folic Acid and Homocysteine Plasma in Severe Pre-Eclampsia and Normal PregnancyInke Malahayati0Joserizal Serudji1Delmi Sulastri2Poltekkes Kemenkes Medan, Midwifery Study Program of Pematang Siantar, Sumatera Utara 20137, IndonesiaDepartment of Obstetrics Gynecology Faculty of Medicine, Universitas Andalas, Sumatera Barat 25163, IndonesiaNutrition Department Faculty of Medicine, Universitas Andalas, Sumatera Barat 25163, IndonesiaBackground: Lack of folic acid intake or genetic abnormalities in folic acid metabolism was correlates with elevated plasma or serum homocysteine concentrations. This case-control analytical study aims to determine the correlation between folic acid and homocysteine levels in severe pre-eclampsia and normal pregnancy. Methods: We enrolled 46 pregnant women (age 20─35 years) with severe pre-eclampsia or normal pregnancy at a government hospital in Padang, Indonesia, between March and May 2015. The samples size was selected by consecutive sampling. Then, we determined folic acid and homocysteine levels using ELISA and statistical analysis using the independent t-test and Pearson correlation. Results: We observed a difference in folic acid levels between severe pre-eclampsia (39.48 ± 9.40 ng/mL) and normal pregnancy (47.04 ± 13.20 ng/mL, p < 0.05). A difference was also observed in homocysteine levels between pre-eclampsia (18.52 ± 0.41 pmol/mL) and normal pregnancy (17.80 ± 0.73 pmol/mL, p < 0.05). The correlation between folic acid and homocysteine in severe pre-eclampsia and normal pregnancy was negative (r = -0.034, p > 0.05 and r = -0.222, p > 0.05, respectively). Conclusions: Low folic acid levels tend to increase homocysteine levels in severe pre-eclampsia, whereas high folic acid levels tend to lower homocysteine levels in normal pregnancy.https://scholarhub.ui.ac.id/mjhr/vol22/iss2/4/folic acidhomocysteinepre-eclampsiapregnancy |
| spellingShingle | Inke Malahayati Joserizal Serudji Delmi Sulastri Correlation between Folic Acid and Homocysteine Plasma in Severe Pre-Eclampsia and Normal Pregnancy Makara Journal of Health Research folic acid homocysteine pre-eclampsia pregnancy |
| title | Correlation between Folic Acid and Homocysteine Plasma in Severe Pre-Eclampsia and Normal Pregnancy |
| title_full | Correlation between Folic Acid and Homocysteine Plasma in Severe Pre-Eclampsia and Normal Pregnancy |
| title_fullStr | Correlation between Folic Acid and Homocysteine Plasma in Severe Pre-Eclampsia and Normal Pregnancy |
| title_full_unstemmed | Correlation between Folic Acid and Homocysteine Plasma in Severe Pre-Eclampsia and Normal Pregnancy |
| title_short | Correlation between Folic Acid and Homocysteine Plasma in Severe Pre-Eclampsia and Normal Pregnancy |
| title_sort | correlation between folic acid and homocysteine plasma in severe pre eclampsia and normal pregnancy |
| topic | folic acid homocysteine pre-eclampsia pregnancy |
| url | https://scholarhub.ui.ac.id/mjhr/vol22/iss2/4/ |
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