A longitudinal analysis of the relationship between serum uric acid and residual renal function loss in peritoneal dialysis patients
Background Hyperuricemia occurs frequently in patients with continuous ambulatory peritoneal dialysis (CAPD). This study aimed to evaluate the impact of serum uric acid (UA) over time on residual renal function (RRF) loss in a cohort of patients with CAPD. Methods A total of 201 patients who started...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2020-01-01
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| Series: | Renal Failure |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/0886022X.2020.1761387 |
| _version_ | 1818914850694234112 |
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| author | Chiehlun Yang Xinxin Ma Wenbo Zhao Yanru Chen Hongchun Lin Dan Luo Jun Zhang Tanqi Lou Yu Peng Hui Peng |
| author_facet | Chiehlun Yang Xinxin Ma Wenbo Zhao Yanru Chen Hongchun Lin Dan Luo Jun Zhang Tanqi Lou Yu Peng Hui Peng |
| author_sort | Chiehlun Yang |
| collection | DOAJ |
| description | Background Hyperuricemia occurs frequently in patients with continuous ambulatory peritoneal dialysis (CAPD). This study aimed to evaluate the impact of serum uric acid (UA) over time on residual renal function (RRF) loss in a cohort of patients with CAPD. Methods A total of 201 patients who started CAPD therapy between January 1, 2008 and April 30, 2016 were included in this single-center, retrospective cohort study. All patients were followed up until December 31, 2016. The median follow-up time was 23.43 ± 16.60 months. RRF loss was represented as the time to anuria. Results Eighty-six patients developed anuria within 5 years. Multivariate Cox regression analysis showed that time-averaged serum UA and peritonitis were independent risk factors for RRF loss, while weekly Kt/V urea was a protective factor. Cox proportional hazard regression models showed that both patients with time-averaged uric acid (TA-UA) < 6.77 mg/dL [hazard ratio (HR) = 1.165, 95% confidence interval (CI) 1.054–1.387; p < 0.05] and those with TA-UA≥ 7.64 mg/dL (HR = 1.184, 95% CI 1.045–2.114; p < 0.05) had a higher risk of RRF than those with TA-UA in the range of 6.77–7.64 mg/dL. Penalized spline smoothing also showed a U-shaped relationship between continuous UA and RRF loss. Conclusion The present study demonstrated that both high and low serum UA over time were associated with RRF loss in patients with CAPD. |
| first_indexed | 2024-12-19T23:52:56Z |
| format | Article |
| id | doaj.art-196498917d6244acb60dd9109ec0013c |
| institution | Directory Open Access Journal |
| issn | 0886-022X 1525-6049 |
| language | English |
| last_indexed | 2024-12-19T23:52:56Z |
| publishDate | 2020-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Renal Failure |
| spelling | doaj.art-196498917d6244acb60dd9109ec0013c2022-12-21T20:01:04ZengTaylor & Francis GroupRenal Failure0886-022X1525-60492020-01-0142144745410.1080/0886022X.2020.17613871761387A longitudinal analysis of the relationship between serum uric acid and residual renal function loss in peritoneal dialysis patientsChiehlun Yang0Xinxin Ma1Wenbo Zhao2Yanru Chen3Hongchun Lin4Dan Luo5Jun Zhang6Tanqi Lou7Yu Peng8Hui Peng9Nephrology Division, Department of Medicine, The Third Affiliated Hospital of Sun Yat-Sen UniversityNephrology Division, Department of Medicine, The Third Affiliated Hospital of Sun Yat-Sen UniversityNephrology Division, Department of Medicine, The Third Affiliated Hospital of Sun Yat-Sen UniversityNephrology Division, Department of Medicine, The Third Affiliated Hospital of Sun Yat-Sen UniversityNephrology Division, Department of Medicine, The Third Affiliated Hospital of Sun Yat-Sen UniversityNephrology Division, Department of Medicine, The Third Affiliated Hospital of Sun Yat-Sen UniversityNephrology Division, Department of Medicine, The Third Affiliated Hospital of Sun Yat-Sen UniversityNephrology Division, Department of Medicine, The Third Affiliated Hospital of Sun Yat-Sen UniversityNephrology Division, Department of Medicine, Guangdong Province Traditional Chinese Medical HospitalNephrology Division, Department of Medicine, The Third Affiliated Hospital of Sun Yat-Sen UniversityBackground Hyperuricemia occurs frequently in patients with continuous ambulatory peritoneal dialysis (CAPD). This study aimed to evaluate the impact of serum uric acid (UA) over time on residual renal function (RRF) loss in a cohort of patients with CAPD. Methods A total of 201 patients who started CAPD therapy between January 1, 2008 and April 30, 2016 were included in this single-center, retrospective cohort study. All patients were followed up until December 31, 2016. The median follow-up time was 23.43 ± 16.60 months. RRF loss was represented as the time to anuria. Results Eighty-six patients developed anuria within 5 years. Multivariate Cox regression analysis showed that time-averaged serum UA and peritonitis were independent risk factors for RRF loss, while weekly Kt/V urea was a protective factor. Cox proportional hazard regression models showed that both patients with time-averaged uric acid (TA-UA) < 6.77 mg/dL [hazard ratio (HR) = 1.165, 95% confidence interval (CI) 1.054–1.387; p < 0.05] and those with TA-UA≥ 7.64 mg/dL (HR = 1.184, 95% CI 1.045–2.114; p < 0.05) had a higher risk of RRF than those with TA-UA in the range of 6.77–7.64 mg/dL. Penalized spline smoothing also showed a U-shaped relationship between continuous UA and RRF loss. Conclusion The present study demonstrated that both high and low serum UA over time were associated with RRF loss in patients with CAPD.http://dx.doi.org/10.1080/0886022X.2020.1761387peritoneal dialysisuric acidresidual renal functionend-stage renal disease |
| spellingShingle | Chiehlun Yang Xinxin Ma Wenbo Zhao Yanru Chen Hongchun Lin Dan Luo Jun Zhang Tanqi Lou Yu Peng Hui Peng A longitudinal analysis of the relationship between serum uric acid and residual renal function loss in peritoneal dialysis patients Renal Failure peritoneal dialysis uric acid residual renal function end-stage renal disease |
| title | A longitudinal analysis of the relationship between serum uric acid and residual renal function loss in peritoneal dialysis patients |
| title_full | A longitudinal analysis of the relationship between serum uric acid and residual renal function loss in peritoneal dialysis patients |
| title_fullStr | A longitudinal analysis of the relationship between serum uric acid and residual renal function loss in peritoneal dialysis patients |
| title_full_unstemmed | A longitudinal analysis of the relationship between serum uric acid and residual renal function loss in peritoneal dialysis patients |
| title_short | A longitudinal analysis of the relationship between serum uric acid and residual renal function loss in peritoneal dialysis patients |
| title_sort | longitudinal analysis of the relationship between serum uric acid and residual renal function loss in peritoneal dialysis patients |
| topic | peritoneal dialysis uric acid residual renal function end-stage renal disease |
| url | http://dx.doi.org/10.1080/0886022X.2020.1761387 |
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