New Insights Into the Skin Microbial Communities and Skin Aging
Although it is well-known that human skin aging is accompanied by an alteration in the skin microbiota, we know little about how the composition of these changes during the course of aging and the effects of age-related skin microbes on aging. Using 16S ribosomal DNA and internal transcribed spacer...
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-10-01
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| Series: | Frontiers in Microbiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fmicb.2020.565549/full |
| _version_ | 1811323795018874880 |
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| author | Zichao Li Xiaozhi Bai Tingwei Peng Xiaowei Yi Liang Luo Jizhong Yang Jiaqi Liu Yunchuan Wang Ting He Xujie Wang Huayu Zhu Hongtao Wang Ke Tao Zhao Zheng Linlin Su Dahai Hu |
| author_facet | Zichao Li Xiaozhi Bai Tingwei Peng Xiaowei Yi Liang Luo Jizhong Yang Jiaqi Liu Yunchuan Wang Ting He Xujie Wang Huayu Zhu Hongtao Wang Ke Tao Zhao Zheng Linlin Su Dahai Hu |
| author_sort | Zichao Li |
| collection | DOAJ |
| description | Although it is well-known that human skin aging is accompanied by an alteration in the skin microbiota, we know little about how the composition of these changes during the course of aging and the effects of age-related skin microbes on aging. Using 16S ribosomal DNA and internal transcribed spacer ribosomal DNA sequencing to profile the microbiomes of 160 skin samples from two anatomical sites, the cheek and the abdomen, on 80 individuals of varying ages, we developed age-related microbiota profiles for both intrinsic skin aging and photoaging to provide an improved understanding of the age-dependent variation in skin microbial composition. According to the landscape, the microbial composition in the Children group was significantly different from that in the other age groups. Further correlation analysis with clinical parameters and functional prediction in each group revealed that high enrichment of nine microbial communities (i.e., Cyanobacteria, Staphylococcus, Cutibacterium, Lactobacillus, Corynebacterium, Streptococcus, Neisseria, Candida, and Malassezia) and 18 pathways (such as biosynthesis of antibiotics) potentially affected skin aging, implying that skin microbiomes may perform key functions in skin aging by regulating the immune response, resistance to ultraviolet light, and biosynthesis and metabolism of age-related substances. Our work re-establishes that skin microbiomes play an important regulatory role in the aging process and opens a new approach for targeted microbial therapy for skin aging. |
| first_indexed | 2024-04-13T14:01:48Z |
| format | Article |
| id | doaj.art-19655aaae1d44d2cbe5198727dcdf44c |
| institution | Directory Open Access Journal |
| issn | 1664-302X |
| language | English |
| last_indexed | 2024-04-13T14:01:48Z |
| publishDate | 2020-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj.art-19655aaae1d44d2cbe5198727dcdf44c2022-12-22T02:44:01ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2020-10-011110.3389/fmicb.2020.565549565549New Insights Into the Skin Microbial Communities and Skin AgingZichao Li0Xiaozhi Bai1Tingwei Peng2Xiaowei Yi3Liang Luo4Jizhong Yang5Jiaqi Liu6Yunchuan Wang7Ting He8Xujie Wang9Huayu Zhu10Hongtao Wang11Ke Tao12Zhao Zheng13Linlin Su14Dahai Hu15Department of Burns and Cutaneous Surgery, Xijing Hospital, Fourth Military Medical University, Xi’an, ChinaDepartment of Burns and Cutaneous Surgery, Xijing Hospital, Fourth Military Medical University, Xi’an, ChinaDepartment of Cardiology, Tangdu Hospital, Fourth Military Medical University, Xi’an, ChinaWest China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, ChinaDepartment of Burns and Cutaneous Surgery, Xijing Hospital, Fourth Military Medical University, Xi’an, ChinaDepartment of Plastic Surgery, Xijing Hospital, Fourth Military Medical University, Xi’an, ChinaDepartment of Burns and Cutaneous Surgery, Xijing Hospital, Fourth Military Medical University, Xi’an, ChinaDepartment of Burns and Cutaneous Surgery, Xijing Hospital, Fourth Military Medical University, Xi’an, ChinaDepartment of Burns and Cutaneous Surgery, Xijing Hospital, Fourth Military Medical University, Xi’an, ChinaDepartment of Burns and Cutaneous Surgery, Xijing Hospital, Fourth Military Medical University, Xi’an, ChinaDepartment of Burns and Cutaneous Surgery, Xijing Hospital, Fourth Military Medical University, Xi’an, ChinaDepartment of Burns and Cutaneous Surgery, Xijing Hospital, Fourth Military Medical University, Xi’an, ChinaDepartment of Burns and Cutaneous Surgery, Xijing Hospital, Fourth Military Medical University, Xi’an, ChinaDepartment of Burns and Cutaneous Surgery, Xijing Hospital, Fourth Military Medical University, Xi’an, ChinaDepartment of Burns and Cutaneous Surgery, Xijing Hospital, Fourth Military Medical University, Xi’an, ChinaDepartment of Burns and Cutaneous Surgery, Xijing Hospital, Fourth Military Medical University, Xi’an, ChinaAlthough it is well-known that human skin aging is accompanied by an alteration in the skin microbiota, we know little about how the composition of these changes during the course of aging and the effects of age-related skin microbes on aging. Using 16S ribosomal DNA and internal transcribed spacer ribosomal DNA sequencing to profile the microbiomes of 160 skin samples from two anatomical sites, the cheek and the abdomen, on 80 individuals of varying ages, we developed age-related microbiota profiles for both intrinsic skin aging and photoaging to provide an improved understanding of the age-dependent variation in skin microbial composition. According to the landscape, the microbial composition in the Children group was significantly different from that in the other age groups. Further correlation analysis with clinical parameters and functional prediction in each group revealed that high enrichment of nine microbial communities (i.e., Cyanobacteria, Staphylococcus, Cutibacterium, Lactobacillus, Corynebacterium, Streptococcus, Neisseria, Candida, and Malassezia) and 18 pathways (such as biosynthesis of antibiotics) potentially affected skin aging, implying that skin microbiomes may perform key functions in skin aging by regulating the immune response, resistance to ultraviolet light, and biosynthesis and metabolism of age-related substances. Our work re-establishes that skin microbiomes play an important regulatory role in the aging process and opens a new approach for targeted microbial therapy for skin aging.https://www.frontiersin.org/articles/10.3389/fmicb.2020.565549/fullskin microbiomesintrinsic skin agingphotoagingVISIAskin immune regulation |
| spellingShingle | Zichao Li Xiaozhi Bai Tingwei Peng Xiaowei Yi Liang Luo Jizhong Yang Jiaqi Liu Yunchuan Wang Ting He Xujie Wang Huayu Zhu Hongtao Wang Ke Tao Zhao Zheng Linlin Su Dahai Hu New Insights Into the Skin Microbial Communities and Skin Aging Frontiers in Microbiology skin microbiomes intrinsic skin aging photoaging VISIA skin immune regulation |
| title | New Insights Into the Skin Microbial Communities and Skin Aging |
| title_full | New Insights Into the Skin Microbial Communities and Skin Aging |
| title_fullStr | New Insights Into the Skin Microbial Communities and Skin Aging |
| title_full_unstemmed | New Insights Into the Skin Microbial Communities and Skin Aging |
| title_short | New Insights Into the Skin Microbial Communities and Skin Aging |
| title_sort | new insights into the skin microbial communities and skin aging |
| topic | skin microbiomes intrinsic skin aging photoaging VISIA skin immune regulation |
| url | https://www.frontiersin.org/articles/10.3389/fmicb.2020.565549/full |
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