Metabolic pathways regulating the development and non-genomic heritable traits of germ cells
Metabolism is an important cellular process necessary not only for producing energy and building blocks for cells, but also for regulating various cell functions, including intracellular signaling, epigenomic effects, and transcription. The regulatory roles of metabolism have been extensively studie...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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The Society for Reproduction and Development
2021-12-01
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| Series: | The Journal of Reproduction and Development |
| Subjects: | |
| Online Access: | https://www.jstage.jst.go.jp/article/jrd/68/2/68_2021-137/_pdf/-char/en |
| _version_ | 1797633917768957952 |
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| author | Yasuhisa MATSUI Yohei HAYASHI |
| author_facet | Yasuhisa MATSUI Yohei HAYASHI |
| author_sort | Yasuhisa MATSUI |
| collection | DOAJ |
| description | Metabolism is an important cellular process necessary not only for producing energy and building blocks for cells, but also for regulating various cell functions, including intracellular signaling, epigenomic effects, and transcription. The regulatory roles of metabolism have been extensively studied in somatic cells, including stem cells and cancer cells, but data regarding germ cells are limited. Because germ cells produce individuals of subsequent generations, understanding the role of metabolism and its regulatory functions in germ cells is important. Although limited information concerning the specific role of metabolism in germ cells is available, recent advances in related research have revealed specific metabolic states of undifferentiated germ cells in embryos as well as in germ cells undergoing oogenesis and spermatogenesis. Studies have also elucidated the functions of some metabolic pathways associated with germ cell development and the non-genomic heritable machinery of germ cells. In this review, we summarized all the available knowledge on the characteristic metabolic pathways in germ cells, focusing on their regulatory functions, while discussing the issues that need to be addressed to enhance the understanding of germ cell metabolism. |
| first_indexed | 2024-03-11T12:01:22Z |
| format | Article |
| id | doaj.art-196570faf15b4ec9beae13341367e82c |
| institution | Directory Open Access Journal |
| issn | 0916-8818 1348-4400 |
| language | English |
| last_indexed | 2024-03-11T12:01:22Z |
| publishDate | 2021-12-01 |
| publisher | The Society for Reproduction and Development |
| record_format | Article |
| series | The Journal of Reproduction and Development |
| spelling | doaj.art-196570faf15b4ec9beae13341367e82c2023-11-08T05:07:03ZengThe Society for Reproduction and DevelopmentThe Journal of Reproduction and Development0916-88181348-44002021-12-016829610310.1262/jrd.2021-137jrdMetabolic pathways regulating the development and non-genomic heritable traits of germ cellsYasuhisa MATSUI0Yohei HAYASHI1Cell Resource Center for Biomedical Research, Institute of Development, Aging and Cancer (IDAC), Tohoku University, Miyagi 980-8575, JapanCell Resource Center for Biomedical Research, Institute of Development, Aging and Cancer (IDAC), Tohoku University, Miyagi 980-8575, JapanMetabolism is an important cellular process necessary not only for producing energy and building blocks for cells, but also for regulating various cell functions, including intracellular signaling, epigenomic effects, and transcription. The regulatory roles of metabolism have been extensively studied in somatic cells, including stem cells and cancer cells, but data regarding germ cells are limited. Because germ cells produce individuals of subsequent generations, understanding the role of metabolism and its regulatory functions in germ cells is important. Although limited information concerning the specific role of metabolism in germ cells is available, recent advances in related research have revealed specific metabolic states of undifferentiated germ cells in embryos as well as in germ cells undergoing oogenesis and spermatogenesis. Studies have also elucidated the functions of some metabolic pathways associated with germ cell development and the non-genomic heritable machinery of germ cells. In this review, we summarized all the available knowledge on the characteristic metabolic pathways in germ cells, focusing on their regulatory functions, while discussing the issues that need to be addressed to enhance the understanding of germ cell metabolism.https://www.jstage.jst.go.jp/article/jrd/68/2/68_2021-137/_pdf/-char/enepigenomegerm cellsmetabolismoogenesisspermatogenesis |
| spellingShingle | Yasuhisa MATSUI Yohei HAYASHI Metabolic pathways regulating the development and non-genomic heritable traits of germ cells The Journal of Reproduction and Development epigenome germ cells metabolism oogenesis spermatogenesis |
| title | Metabolic pathways regulating the development and non-genomic heritable traits of germ cells |
| title_full | Metabolic pathways regulating the development and non-genomic heritable traits of germ cells |
| title_fullStr | Metabolic pathways regulating the development and non-genomic heritable traits of germ cells |
| title_full_unstemmed | Metabolic pathways regulating the development and non-genomic heritable traits of germ cells |
| title_short | Metabolic pathways regulating the development and non-genomic heritable traits of germ cells |
| title_sort | metabolic pathways regulating the development and non genomic heritable traits of germ cells |
| topic | epigenome germ cells metabolism oogenesis spermatogenesis |
| url | https://www.jstage.jst.go.jp/article/jrd/68/2/68_2021-137/_pdf/-char/en |
| work_keys_str_mv | AT yasuhisamatsui metabolicpathwaysregulatingthedevelopmentandnongenomicheritabletraitsofgermcells AT yoheihayashi metabolicpathwaysregulatingthedevelopmentandnongenomicheritabletraitsofgermcells |