Aberrant induction of p19Arf-mediated cellular senescence contributes to neurodevelopmental defects

Aberrant induction of p19Arf-mediated cellular senescence contributes to neurodevelopmental defects

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Valproic acid (VPA) is a widely prescribed drug to treat epilepsy, bipolar disorder, and migraine. If taken during pregnancy, however, exposure to the developing embryo can cause birth defects, cognitive impairment, and autism spectrum disorder. How VPA causes these developmental defects remains unk...

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Bibliographic Details
Main Authors: Muriel Rhinn, Irene Zapata-Bodalo, Annabelle Klein, Jean-Luc Plassat, Tania Knauer-Meyer, William M. Keyes
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2022-06-01
Series:PLoS Biology
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9197032/?tool=EBI

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