Expression of Cartilage Oligomeric Matrix Protein in colorectal cancer is an adverse prognostic factor and correlates negatively with infiltrating immune cells and PD-L1 expression

Expression of Cartilage Oligomeric Matrix Protein in colorectal cancer is an adverse prognostic factor and correlates negatively with infiltrating immune cells and PD-L1 expression

IntroductionCartilage Oligomeric Matrix Protein (COMP) is an oncogenic protein that has been associated with a decrease in infiltrating T-cells in periampullary adenocarcinoma. This study aimed to investigate whether this is also the case for colorectal cancer (CRC) and to evaluate the relationship...

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Bibliographic Details
Main Authors: Anna M. Blom, Chrysostomi Gialeli, Catharina Hagerling, Jonna Berntsson, Karin Jirström, Konstantinos S. Papadakos
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-05-01
Series:Frontiers in Immunology
Subjects:
colon cancer
T-cells
PD-L1
collagen
fibrosis
Cartilage Oligomeric Matrix Protein (COMP)
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1167659/full

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