Cell mechanics and cell-cell recognition controls by Toll-like receptors in tissue morphogenesis and homeostasis
Signal transduction by the Toll-like receptors (TLRs) is conserved and essential for innate immunity in metazoans. The founding member of the TLR family, Drosophila Toll-1, was initially identified for its role in dorsoventral axis formation in early embryogenesis. The Drosophila genome encodes nine...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2022-12-01
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| Series: | Fly |
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| Online Access: | http://dx.doi.org/10.1080/19336934.2022.2074783 |
| _version_ | 1797678337641938944 |
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| author | Daiki Umetsu |
| author_facet | Daiki Umetsu |
| author_sort | Daiki Umetsu |
| collection | DOAJ |
| description | Signal transduction by the Toll-like receptors (TLRs) is conserved and essential for innate immunity in metazoans. The founding member of the TLR family, Drosophila Toll-1, was initially identified for its role in dorsoventral axis formation in early embryogenesis. The Drosophila genome encodes nine TLRs that display dynamic expression patterns during development, suggesting their involvement in tissue morphogenesis and homeostasis. Recent progress on the developmental functions of TLRs beyond dorsoventral patterning has revealed not only their diverse functions in various biological processes, but also unprecedented molecular mechanisms in directly regulating cell mechanics and cell-cell recognition independent of the canonical signal transduction pathway involving transcriptional regulation of target genes. In this review, I feature and discuss the non-immune functions of TLRs in the control of epithelial tissue homeostasis, tissue morphogenesis, and cell-cell recognition between cell populations with different cell identities. |
| first_indexed | 2024-03-11T22:58:16Z |
| format | Article |
| id | doaj.art-196e42fc38624029997ed4e3f5b369de |
| institution | Directory Open Access Journal |
| issn | 1933-6934 1933-6942 |
| language | English |
| last_indexed | 2024-03-11T22:58:16Z |
| publishDate | 2022-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Fly |
| spelling | doaj.art-196e42fc38624029997ed4e3f5b369de2023-09-21T15:17:01ZengTaylor & Francis GroupFly1933-69341933-69422022-12-0116123324710.1080/19336934.2022.20747832074783Cell mechanics and cell-cell recognition controls by Toll-like receptors in tissue morphogenesis and homeostasisDaiki Umetsu0Tohoku UniversitySignal transduction by the Toll-like receptors (TLRs) is conserved and essential for innate immunity in metazoans. The founding member of the TLR family, Drosophila Toll-1, was initially identified for its role in dorsoventral axis formation in early embryogenesis. The Drosophila genome encodes nine TLRs that display dynamic expression patterns during development, suggesting their involvement in tissue morphogenesis and homeostasis. Recent progress on the developmental functions of TLRs beyond dorsoventral patterning has revealed not only their diverse functions in various biological processes, but also unprecedented molecular mechanisms in directly regulating cell mechanics and cell-cell recognition independent of the canonical signal transduction pathway involving transcriptional regulation of target genes. In this review, I feature and discuss the non-immune functions of TLRs in the control of epithelial tissue homeostasis, tissue morphogenesis, and cell-cell recognition between cell populations with different cell identities.http://dx.doi.org/10.1080/19336934.2022.2074783toll-like receptorsplanar polaritymyosin iicell-cell adhesioncell recognitiontissue morphogenesiscell competitioncell mechanics |
| spellingShingle | Daiki Umetsu Cell mechanics and cell-cell recognition controls by Toll-like receptors in tissue morphogenesis and homeostasis Fly toll-like receptors planar polarity myosin ii cell-cell adhesion cell recognition tissue morphogenesis cell competition cell mechanics |
| title | Cell mechanics and cell-cell recognition controls by Toll-like receptors in tissue morphogenesis and homeostasis |
| title_full | Cell mechanics and cell-cell recognition controls by Toll-like receptors in tissue morphogenesis and homeostasis |
| title_fullStr | Cell mechanics and cell-cell recognition controls by Toll-like receptors in tissue morphogenesis and homeostasis |
| title_full_unstemmed | Cell mechanics and cell-cell recognition controls by Toll-like receptors in tissue morphogenesis and homeostasis |
| title_short | Cell mechanics and cell-cell recognition controls by Toll-like receptors in tissue morphogenesis and homeostasis |
| title_sort | cell mechanics and cell cell recognition controls by toll like receptors in tissue morphogenesis and homeostasis |
| topic | toll-like receptors planar polarity myosin ii cell-cell adhesion cell recognition tissue morphogenesis cell competition cell mechanics |
| url | http://dx.doi.org/10.1080/19336934.2022.2074783 |
| work_keys_str_mv | AT daikiumetsu cellmechanicsandcellcellrecognitioncontrolsbytolllikereceptorsintissuemorphogenesisandhomeostasis |