Growth and Morphogenesis during Early Heart Development in Amniotes
In this review, we will focus on the growth and morphogenesis of the developing heart, an aspect of cardiovascular development to which Antoon Moorman and colleagues have extensively contributed. Over the last decades, genetic studies and characterization of regionally regulated gene programs have p...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2017-11-01
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| Series: | Journal of Cardiovascular Development and Disease |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2308-3425/4/4/20 |
| _version_ | 1828484091896397824 |
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| author | Kenzo Ivanovitch Isaac Esteban Miguel Torres |
| author_facet | Kenzo Ivanovitch Isaac Esteban Miguel Torres |
| author_sort | Kenzo Ivanovitch |
| collection | DOAJ |
| description | In this review, we will focus on the growth and morphogenesis of the developing heart, an aspect of cardiovascular development to which Antoon Moorman and colleagues have extensively contributed. Over the last decades, genetic studies and characterization of regionally regulated gene programs have provided abundant novel insights into heart development essential to understand the basis of congenital heart disease. Heart morphogenesis, however, is inherently a complex and dynamic three-dimensional process and we are far from understanding its cellular basis. Here, we discuss recent advances in studying heart morphogenesis and regionalization under the light of the pioneering work of Moorman and colleagues, which allowed the reinterpretation of regional gene expression patterns under a new morphogenetic framework. Two aspects of early heart formation will be discussed in particular: (1) the initial formation of the heart tube and (2) the formation of the cardiac chambers by the ballooning process. Finally, we emphasize that in addition to analyses based on fixed samples, new approaches including clonal analysis, single-cell sequencing, live-imaging and quantitative analysis of the data generated will likely lead to novel insights in understanding early heart tube regionalization and morphogenesis in the near future. |
| first_indexed | 2024-12-11T08:49:57Z |
| format | Article |
| id | doaj.art-196f187915a54d1c844a61ddffa501e7 |
| institution | Directory Open Access Journal |
| issn | 2308-3425 |
| language | English |
| last_indexed | 2024-12-11T08:49:57Z |
| publishDate | 2017-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Cardiovascular Development and Disease |
| spelling | doaj.art-196f187915a54d1c844a61ddffa501e72022-12-22T01:14:02ZengMDPI AGJournal of Cardiovascular Development and Disease2308-34252017-11-01442010.3390/jcdd4040020jcdd4040020Growth and Morphogenesis during Early Heart Development in AmniotesKenzo Ivanovitch0Isaac Esteban1Miguel Torres2Developmental Biology Program, Centro Nacional de Investigaciones Cardiovasculares (CNIC), 28029 Madrid, SpainDevelopmental Biology Program, Centro Nacional de Investigaciones Cardiovasculares (CNIC), 28029 Madrid, SpainDevelopmental Biology Program, Centro Nacional de Investigaciones Cardiovasculares (CNIC), 28029 Madrid, SpainIn this review, we will focus on the growth and morphogenesis of the developing heart, an aspect of cardiovascular development to which Antoon Moorman and colleagues have extensively contributed. Over the last decades, genetic studies and characterization of regionally regulated gene programs have provided abundant novel insights into heart development essential to understand the basis of congenital heart disease. Heart morphogenesis, however, is inherently a complex and dynamic three-dimensional process and we are far from understanding its cellular basis. Here, we discuss recent advances in studying heart morphogenesis and regionalization under the light of the pioneering work of Moorman and colleagues, which allowed the reinterpretation of regional gene expression patterns under a new morphogenetic framework. Two aspects of early heart formation will be discussed in particular: (1) the initial formation of the heart tube and (2) the formation of the cardiac chambers by the ballooning process. Finally, we emphasize that in addition to analyses based on fixed samples, new approaches including clonal analysis, single-cell sequencing, live-imaging and quantitative analysis of the data generated will likely lead to novel insights in understanding early heart tube regionalization and morphogenesis in the near future.https://www.mdpi.com/2308-3425/4/4/20heart tubecardiac crescentcardiac differentiationfirst heart fieldsecond heart fieldcardiomyocytelive-imaging |
| spellingShingle | Kenzo Ivanovitch Isaac Esteban Miguel Torres Growth and Morphogenesis during Early Heart Development in Amniotes Journal of Cardiovascular Development and Disease heart tube cardiac crescent cardiac differentiation first heart field second heart field cardiomyocyte live-imaging |
| title | Growth and Morphogenesis during Early Heart Development in Amniotes |
| title_full | Growth and Morphogenesis during Early Heart Development in Amniotes |
| title_fullStr | Growth and Morphogenesis during Early Heart Development in Amniotes |
| title_full_unstemmed | Growth and Morphogenesis during Early Heart Development in Amniotes |
| title_short | Growth and Morphogenesis during Early Heart Development in Amniotes |
| title_sort | growth and morphogenesis during early heart development in amniotes |
| topic | heart tube cardiac crescent cardiac differentiation first heart field second heart field cardiomyocyte live-imaging |
| url | https://www.mdpi.com/2308-3425/4/4/20 |
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