Ability of spectral domain optical coherence tomography peripapillary retinal nerve fiber layer thickness measurements to identify early glaucoma
Purpose : To evaluate the ability of spectral domain optical coherence tomography (OCT) peripapillary retinal nerve fiber layer thickness (RNFLT) parameters to distinguish normal eyes from those with early glaucoma in Asian Indian eyes. Design : Observational cross-sectional study. Materials and Met...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2011-01-01
|
| Series: | Indian Journal of Ophthalmology |
| Subjects: | |
| Online Access: | http://www.ijo.in/article.asp?issn=0301-4738;year=2011;volume=59;issue=6;spage=455;epage=459;aulast=Mansoori |
| _version_ | 1818172337875320832 |
|---|---|
| author | Tarannum Mansoori Kalluri Viswanath Nagalla Balakrishna |
| author_facet | Tarannum Mansoori Kalluri Viswanath Nagalla Balakrishna |
| author_sort | Tarannum Mansoori |
| collection | DOAJ |
| description | Purpose : To evaluate the ability of spectral domain optical coherence tomography (OCT) peripapillary retinal nerve fiber layer thickness (RNFLT) parameters to distinguish normal eyes from those with early glaucoma in Asian Indian eyes. Design : Observational cross-sectional study. Materials and Methods : One hundred and seventy eight eyes (83 glaucoma patients and 95 age matched healthy subjects) of subjects more than 40 years of age were included in the study. All subjects underwent RNFLT measurement with spectral OCT/ scanning laser ophthalmoscope (SLO) after dilatation. Sensitivity, specificity and area under the receiving operating characteristic curve (AROC) were calculated for various OCT peripapillary RNFL parameters. Results: The mean RNFLT in healthy subjects and patients with early glaucoma were 105.7 ± 5.1 μm and 90.7 ± 7.5 μm, respectively. The largest AROC was found for 12 o′clock- hour (0.98), average (0.96) and superior quadrant RNFLT (0.9). When target specificity was set at ≥ 90% and ≥ 80%, the parameters with highest sensitivity were 12 o′clock -hour (91.6%), average RNFLT (85.3%) and 12 o′ clock- hour (96.8 %), average RNFLT (94.7%) respectively. Conclusion : Our study showed good ability of spectral OCT/ SLO to differentiate normal eyes from patients with early glaucoma and hence it may serve as an useful adjunct for early diagnosis of glaucoma. |
| first_indexed | 2024-12-11T19:11:01Z |
| format | Article |
| id | doaj.art-1971208917004c97a5985ad347c4dab7 |
| institution | Directory Open Access Journal |
| issn | 0301-4738 1998-3689 |
| language | English |
| last_indexed | 2024-12-11T19:11:01Z |
| publishDate | 2011-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Ophthalmology |
| spelling | doaj.art-1971208917004c97a5985ad347c4dab72022-12-22T00:53:46ZengWolters Kluwer Medknow PublicationsIndian Journal of Ophthalmology0301-47381998-36892011-01-0159645545910.4103/0301-4738.86312Ability of spectral domain optical coherence tomography peripapillary retinal nerve fiber layer thickness measurements to identify early glaucomaTarannum MansooriKalluri ViswanathNagalla BalakrishnaPurpose : To evaluate the ability of spectral domain optical coherence tomography (OCT) peripapillary retinal nerve fiber layer thickness (RNFLT) parameters to distinguish normal eyes from those with early glaucoma in Asian Indian eyes. Design : Observational cross-sectional study. Materials and Methods : One hundred and seventy eight eyes (83 glaucoma patients and 95 age matched healthy subjects) of subjects more than 40 years of age were included in the study. All subjects underwent RNFLT measurement with spectral OCT/ scanning laser ophthalmoscope (SLO) after dilatation. Sensitivity, specificity and area under the receiving operating characteristic curve (AROC) were calculated for various OCT peripapillary RNFL parameters. Results: The mean RNFLT in healthy subjects and patients with early glaucoma were 105.7 ± 5.1 μm and 90.7 ± 7.5 μm, respectively. The largest AROC was found for 12 o′clock- hour (0.98), average (0.96) and superior quadrant RNFLT (0.9). When target specificity was set at ≥ 90% and ≥ 80%, the parameters with highest sensitivity were 12 o′clock -hour (91.6%), average RNFLT (85.3%) and 12 o′ clock- hour (96.8 %), average RNFLT (94.7%) respectively. Conclusion : Our study showed good ability of spectral OCT/ SLO to differentiate normal eyes from patients with early glaucoma and hence it may serve as an useful adjunct for early diagnosis of glaucoma.http://www.ijo.in/article.asp?issn=0301-4738;year=2011;volume=59;issue=6;spage=455;epage=459;aulast=MansooriMyopiaprethreshold retinopathy of prematurityretinopathy of prematurityRetinopathy of prematurityscreeningsurveyAnthraxcommunity-acquired methicillin-resistant Staphyloccus aureusorbital cellulitispreseptal cellulitisIntrastromal corneal ring segments; keraring; post-LASIK ectasiaBlebitisbleb leakmicrobiologyocular surface diseasesrisk factorsEarly glaucomaretinal nerve fiber layer thicknessspectral optical coherence tomography / scanning laser ophthalmoscope |
| spellingShingle | Tarannum Mansoori Kalluri Viswanath Nagalla Balakrishna Ability of spectral domain optical coherence tomography peripapillary retinal nerve fiber layer thickness measurements to identify early glaucoma Indian Journal of Ophthalmology Myopia prethreshold retinopathy of prematurity retinopathy of prematurity Retinopathy of prematurity screening survey Anthrax community-acquired methicillin-resistant Staphyloccus aureus orbital cellulitis preseptal cellulitis Intrastromal corneal ring segments; keraring; post-LASIK ectasia Blebitis bleb leak microbiology ocular surface diseases risk factors Early glaucoma retinal nerve fiber layer thickness spectral optical coherence tomography / scanning laser ophthalmoscope |
| title | Ability of spectral domain optical coherence tomography peripapillary retinal nerve fiber layer thickness measurements to identify early glaucoma |
| title_full | Ability of spectral domain optical coherence tomography peripapillary retinal nerve fiber layer thickness measurements to identify early glaucoma |
| title_fullStr | Ability of spectral domain optical coherence tomography peripapillary retinal nerve fiber layer thickness measurements to identify early glaucoma |
| title_full_unstemmed | Ability of spectral domain optical coherence tomography peripapillary retinal nerve fiber layer thickness measurements to identify early glaucoma |
| title_short | Ability of spectral domain optical coherence tomography peripapillary retinal nerve fiber layer thickness measurements to identify early glaucoma |
| title_sort | ability of spectral domain optical coherence tomography peripapillary retinal nerve fiber layer thickness measurements to identify early glaucoma |
| topic | Myopia prethreshold retinopathy of prematurity retinopathy of prematurity Retinopathy of prematurity screening survey Anthrax community-acquired methicillin-resistant Staphyloccus aureus orbital cellulitis preseptal cellulitis Intrastromal corneal ring segments; keraring; post-LASIK ectasia Blebitis bleb leak microbiology ocular surface diseases risk factors Early glaucoma retinal nerve fiber layer thickness spectral optical coherence tomography / scanning laser ophthalmoscope |
| url | http://www.ijo.in/article.asp?issn=0301-4738;year=2011;volume=59;issue=6;spage=455;epage=459;aulast=Mansoori |
| work_keys_str_mv | AT tarannummansoori abilityofspectraldomainopticalcoherencetomographyperipapillaryretinalnervefiberlayerthicknessmeasurementstoidentifyearlyglaucoma AT kalluriviswanath abilityofspectraldomainopticalcoherencetomographyperipapillaryretinalnervefiberlayerthicknessmeasurementstoidentifyearlyglaucoma AT nagallabalakrishna abilityofspectraldomainopticalcoherencetomographyperipapillaryretinalnervefiberlayerthicknessmeasurementstoidentifyearlyglaucoma |