Altered Metabolites in the Occipital Lobe in Migraine Without Aura During the Attack and the Interictal Period
Background: Although there have been many magnetic resonance spectroscopy (MRS) studies of migraine, few have focused on migraines during an attack. Here, we aimed to assess metabolite changes in the brain of patients with migraine, both during an attack and in the interictal phase.Methods: Six pati...
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| Format: | Article |
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Frontiers Media S.A.
2021-05-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2021.656349/full |
| _version_ | 1819085094711721984 |
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| author | Luping Zhang Jinwen Huang Zhengxiang Zhang Zhijian Cao |
| author_facet | Luping Zhang Jinwen Huang Zhengxiang Zhang Zhijian Cao |
| author_sort | Luping Zhang |
| collection | DOAJ |
| description | Background: Although there have been many magnetic resonance spectroscopy (MRS) studies of migraine, few have focused on migraines during an attack. Here, we aimed to assess metabolite changes in the brain of patients with migraine, both during an attack and in the interictal phase.Methods: Six patients (one man and five women, mean age: 39 ± 10 years) with migraine without aura during the attack (MWoA-DA), 13 patients (three men and 10 women, mean age: 31 ± 9 years) with migraine without aura during the interictal period (MWoA-DI), and 13 healthy controls (HC) (four men and nine women, mean age: 31 ± 9 years) were studied. All subjects underwent an MRS examination focusing on the occipital lobe. Metabolite changes were investigated among three groups.Results: The MWoA-DA patients had lower glutathione/total creatine ratio (GSH/tCr) than the MWoA-DI patients and HC. Furthermore, MWoA-DI patients showed lower total choline/total creatine ratio (tCho/tCr) than those in the other two groups. The GSH/tCr ratio was positively correlated with attack frequency in the MWoA-DI group. The tCho/tCr ratio was positively correlated with attack frequency and Migraine Disability Assessment Scale (MIDAS) scores in the MWoA-DA group.Conclusion: The present study suggests the existence of distinct pathophysiological states between the MWoA-DA and MWoA-DI groups. Neuronal dysfunction is a possible predisposing factor for migraine attack onset, along with oxidative stress and inflammation. |
| first_indexed | 2024-12-21T20:58:54Z |
| format | Article |
| id | doaj.art-197327bd2ecf4aa19f4bb7075c6bfc06 |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-12-21T20:58:54Z |
| publishDate | 2021-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-197327bd2ecf4aa19f4bb7075c6bfc062022-12-21T18:50:30ZengFrontiers Media S.A.Frontiers in Neurology1664-22952021-05-011210.3389/fneur.2021.656349656349Altered Metabolites in the Occipital Lobe in Migraine Without Aura During the Attack and the Interictal PeriodLuping Zhang0Jinwen Huang1Zhengxiang Zhang2Zhijian Cao3Department of Radiology, Hangzhou TCM Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou, ChinaThe First Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, ChinaDepartment of Neurology, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, ChinaDepartment of Radiology, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, ChinaBackground: Although there have been many magnetic resonance spectroscopy (MRS) studies of migraine, few have focused on migraines during an attack. Here, we aimed to assess metabolite changes in the brain of patients with migraine, both during an attack and in the interictal phase.Methods: Six patients (one man and five women, mean age: 39 ± 10 years) with migraine without aura during the attack (MWoA-DA), 13 patients (three men and 10 women, mean age: 31 ± 9 years) with migraine without aura during the interictal period (MWoA-DI), and 13 healthy controls (HC) (four men and nine women, mean age: 31 ± 9 years) were studied. All subjects underwent an MRS examination focusing on the occipital lobe. Metabolite changes were investigated among three groups.Results: The MWoA-DA patients had lower glutathione/total creatine ratio (GSH/tCr) than the MWoA-DI patients and HC. Furthermore, MWoA-DI patients showed lower total choline/total creatine ratio (tCho/tCr) than those in the other two groups. The GSH/tCr ratio was positively correlated with attack frequency in the MWoA-DI group. The tCho/tCr ratio was positively correlated with attack frequency and Migraine Disability Assessment Scale (MIDAS) scores in the MWoA-DA group.Conclusion: The present study suggests the existence of distinct pathophysiological states between the MWoA-DA and MWoA-DI groups. Neuronal dysfunction is a possible predisposing factor for migraine attack onset, along with oxidative stress and inflammation.https://www.frontiersin.org/articles/10.3389/fneur.2021.656349/fullglutathionecholinemagnetic resonance spectroscopyoxidative stressinflammationneuronal dysfunction |
| spellingShingle | Luping Zhang Jinwen Huang Zhengxiang Zhang Zhijian Cao Altered Metabolites in the Occipital Lobe in Migraine Without Aura During the Attack and the Interictal Period Frontiers in Neurology glutathione choline magnetic resonance spectroscopy oxidative stress inflammation neuronal dysfunction |
| title | Altered Metabolites in the Occipital Lobe in Migraine Without Aura During the Attack and the Interictal Period |
| title_full | Altered Metabolites in the Occipital Lobe in Migraine Without Aura During the Attack and the Interictal Period |
| title_fullStr | Altered Metabolites in the Occipital Lobe in Migraine Without Aura During the Attack and the Interictal Period |
| title_full_unstemmed | Altered Metabolites in the Occipital Lobe in Migraine Without Aura During the Attack and the Interictal Period |
| title_short | Altered Metabolites in the Occipital Lobe in Migraine Without Aura During the Attack and the Interictal Period |
| title_sort | altered metabolites in the occipital lobe in migraine without aura during the attack and the interictal period |
| topic | glutathione choline magnetic resonance spectroscopy oxidative stress inflammation neuronal dysfunction |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2021.656349/full |
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