The Chemistry of HNO: Mechanisms and Reaction Kinetics
Azanone (HNO, also known as nitroxyl) is the protonated form of the product of one-electron reduction of nitric oxide (•NO), and an elusive electrophilic reactive nitrogen species of increasing pharmacological significance. Over the past 20 years, the interest in the biological chemistry of HNO has...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-07-01
|
| Series: | Frontiers in Chemistry |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fchem.2022.930657/full |
| _version_ | 1818466540941475840 |
|---|---|
| author | Radosław Michalski Renata Smulik-Izydorczyk Jakub Pięta Monika Rola Angelika Artelska Karolina Pierzchała Jacek Zielonka Balaraman Kalyanaraman Adam Bartłomiej Sikora |
| author_facet | Radosław Michalski Renata Smulik-Izydorczyk Jakub Pięta Monika Rola Angelika Artelska Karolina Pierzchała Jacek Zielonka Balaraman Kalyanaraman Adam Bartłomiej Sikora |
| author_sort | Radosław Michalski |
| collection | DOAJ |
| description | Azanone (HNO, also known as nitroxyl) is the protonated form of the product of one-electron reduction of nitric oxide (•NO), and an elusive electrophilic reactive nitrogen species of increasing pharmacological significance. Over the past 20 years, the interest in the biological chemistry of HNO has increased significantly due to the numerous beneficial pharmacological effects of its donors. Increased availability of various HNO donors was accompanied by great progress in the understanding of HNO chemistry and chemical biology. This review is focused on the chemistry of HNO, with emphasis on reaction kinetics and mechanisms in aqueous solutions. |
| first_indexed | 2024-04-13T20:58:44Z |
| format | Article |
| id | doaj.art-1977414ea6e4468c93c4a0979a7609c0 |
| institution | Directory Open Access Journal |
| issn | 2296-2646 |
| language | English |
| last_indexed | 2024-04-13T20:58:44Z |
| publishDate | 2022-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Chemistry |
| spelling | doaj.art-1977414ea6e4468c93c4a0979a7609c02022-12-22T02:30:12ZengFrontiers Media S.A.Frontiers in Chemistry2296-26462022-07-011010.3389/fchem.2022.930657930657The Chemistry of HNO: Mechanisms and Reaction KineticsRadosław Michalski0Renata Smulik-Izydorczyk1Jakub Pięta2Monika Rola3Angelika Artelska4Karolina Pierzchała5Jacek Zielonka6Balaraman Kalyanaraman7Adam Bartłomiej Sikora8Institute of Applied Radiation Chemistry, Lodz University of Technology, Lodz, PolandInstitute of Applied Radiation Chemistry, Lodz University of Technology, Lodz, PolandInstitute of Applied Radiation Chemistry, Lodz University of Technology, Lodz, PolandInstitute of Applied Radiation Chemistry, Lodz University of Technology, Lodz, PolandInstitute of Applied Radiation Chemistry, Lodz University of Technology, Lodz, PolandInstitute of Applied Radiation Chemistry, Lodz University of Technology, Lodz, PolandDepartment of Biophysics, Medical College of Wisconsin, Milwaukee, WI, United StatesDepartment of Biophysics, Medical College of Wisconsin, Milwaukee, WI, United StatesInstitute of Applied Radiation Chemistry, Lodz University of Technology, Lodz, PolandAzanone (HNO, also known as nitroxyl) is the protonated form of the product of one-electron reduction of nitric oxide (•NO), and an elusive electrophilic reactive nitrogen species of increasing pharmacological significance. Over the past 20 years, the interest in the biological chemistry of HNO has increased significantly due to the numerous beneficial pharmacological effects of its donors. Increased availability of various HNO donors was accompanied by great progress in the understanding of HNO chemistry and chemical biology. This review is focused on the chemistry of HNO, with emphasis on reaction kinetics and mechanisms in aqueous solutions.https://www.frontiersin.org/articles/10.3389/fchem.2022.930657/fullazanonenitroxylHNOchemical kineticsreaction mechanism |
| spellingShingle | Radosław Michalski Renata Smulik-Izydorczyk Jakub Pięta Monika Rola Angelika Artelska Karolina Pierzchała Jacek Zielonka Balaraman Kalyanaraman Adam Bartłomiej Sikora The Chemistry of HNO: Mechanisms and Reaction Kinetics Frontiers in Chemistry azanone nitroxyl HNO chemical kinetics reaction mechanism |
| title | The Chemistry of HNO: Mechanisms and Reaction Kinetics |
| title_full | The Chemistry of HNO: Mechanisms and Reaction Kinetics |
| title_fullStr | The Chemistry of HNO: Mechanisms and Reaction Kinetics |
| title_full_unstemmed | The Chemistry of HNO: Mechanisms and Reaction Kinetics |
| title_short | The Chemistry of HNO: Mechanisms and Reaction Kinetics |
| title_sort | chemistry of hno mechanisms and reaction kinetics |
| topic | azanone nitroxyl HNO chemical kinetics reaction mechanism |
| url | https://www.frontiersin.org/articles/10.3389/fchem.2022.930657/full |
| work_keys_str_mv | AT radosławmichalski thechemistryofhnomechanismsandreactionkinetics AT renatasmulikizydorczyk thechemistryofhnomechanismsandreactionkinetics AT jakubpieta thechemistryofhnomechanismsandreactionkinetics AT monikarola thechemistryofhnomechanismsandreactionkinetics AT angelikaartelska thechemistryofhnomechanismsandreactionkinetics AT karolinapierzchała thechemistryofhnomechanismsandreactionkinetics AT jacekzielonka thechemistryofhnomechanismsandreactionkinetics AT balaramankalyanaraman thechemistryofhnomechanismsandreactionkinetics AT adambartłomiejsikora thechemistryofhnomechanismsandreactionkinetics AT radosławmichalski chemistryofhnomechanismsandreactionkinetics AT renatasmulikizydorczyk chemistryofhnomechanismsandreactionkinetics AT jakubpieta chemistryofhnomechanismsandreactionkinetics AT monikarola chemistryofhnomechanismsandreactionkinetics AT angelikaartelska chemistryofhnomechanismsandreactionkinetics AT karolinapierzchała chemistryofhnomechanismsandreactionkinetics AT jacekzielonka chemistryofhnomechanismsandreactionkinetics AT balaramankalyanaraman chemistryofhnomechanismsandreactionkinetics AT adambartłomiejsikora chemistryofhnomechanismsandreactionkinetics |