A review of brain circuitries involved in stuttering
Stuttering has been the subject of much research, nevertheless its aetiology remains incompletely understood. This article presents a critical review of the literature on stuttering, with particular reference to the role of the basal ganglia. Neuroimaging and lesion studies of developmental and acqu...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2014-11-01
|
| Series: | Frontiers in Human Neuroscience |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fnhum.2014.00884/full |
| _version_ | 1828190591065784320 |
|---|---|
| author | Anna eCraig-Mcquaide Harith eAkram Ludvic eZrinzo Elina eTripoliti |
| author_facet | Anna eCraig-Mcquaide Harith eAkram Ludvic eZrinzo Elina eTripoliti |
| author_sort | Anna eCraig-Mcquaide |
| collection | DOAJ |
| description | Stuttering has been the subject of much research, nevertheless its aetiology remains incompletely understood. This article presents a critical review of the literature on stuttering, with particular reference to the role of the basal ganglia. Neuroimaging and lesion studies of developmental and acquired stuttering, as well as pharmacological and genetic studies are discussed. Evidence that stuttering of structural and functional changes in the basal ganglia in those who stutter indicates that this motor speech disorder is due, at least in part, to abnormal basal ganglia cues for the initiation and termination of articulatory movements. Studies discussed provide evidence of a dysfunctional hyperdopaminergic state of the thalamocortical pathways underlying speech motor control in stuttering. Evidence that stuttering can improve, worsen or recur following deep brain stimulation (DBS) for other indications is presented in order to emphasise the role of basal ganglia in stuttering. Further research is needed to fully elucidate the pathophysiology of this speech disorder, which is associated with significant social isolation. |
| first_indexed | 2024-04-12T08:25:02Z |
| format | Article |
| id | doaj.art-197856523eef4a678322304c8de26336 |
| institution | Directory Open Access Journal |
| issn | 1662-5161 |
| language | English |
| last_indexed | 2024-04-12T08:25:02Z |
| publishDate | 2014-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Human Neuroscience |
| spelling | doaj.art-197856523eef4a678322304c8de263362022-12-22T03:40:25ZengFrontiers Media S.A.Frontiers in Human Neuroscience1662-51612014-11-01810.3389/fnhum.2014.00884105398A review of brain circuitries involved in stutteringAnna eCraig-Mcquaide0Harith eAkram1Ludvic eZrinzo2Elina eTripoliti3Imperial College School of MedicineUCL, Institute of Neurology, and UCLH NHS TrustUCL, Institute of Neurology, and UCLH NHS TrustUCL, Institute of Neurology, and UCLH NHS TrustStuttering has been the subject of much research, nevertheless its aetiology remains incompletely understood. This article presents a critical review of the literature on stuttering, with particular reference to the role of the basal ganglia. Neuroimaging and lesion studies of developmental and acquired stuttering, as well as pharmacological and genetic studies are discussed. Evidence that stuttering of structural and functional changes in the basal ganglia in those who stutter indicates that this motor speech disorder is due, at least in part, to abnormal basal ganglia cues for the initiation and termination of articulatory movements. Studies discussed provide evidence of a dysfunctional hyperdopaminergic state of the thalamocortical pathways underlying speech motor control in stuttering. Evidence that stuttering can improve, worsen or recur following deep brain stimulation (DBS) for other indications is presented in order to emphasise the role of basal ganglia in stuttering. Further research is needed to fully elucidate the pathophysiology of this speech disorder, which is associated with significant social isolation.http://journal.frontiersin.org/Journal/10.3389/fnhum.2014.00884/fullBasal GangliaDeep Brain StimulationStutteringThalamuspalilaliaspeech neural control |
| spellingShingle | Anna eCraig-Mcquaide Harith eAkram Ludvic eZrinzo Elina eTripoliti A review of brain circuitries involved in stuttering Frontiers in Human Neuroscience Basal Ganglia Deep Brain Stimulation Stuttering Thalamus palilalia speech neural control |
| title | A review of brain circuitries involved in stuttering |
| title_full | A review of brain circuitries involved in stuttering |
| title_fullStr | A review of brain circuitries involved in stuttering |
| title_full_unstemmed | A review of brain circuitries involved in stuttering |
| title_short | A review of brain circuitries involved in stuttering |
| title_sort | review of brain circuitries involved in stuttering |
| topic | Basal Ganglia Deep Brain Stimulation Stuttering Thalamus palilalia speech neural control |
| url | http://journal.frontiersin.org/Journal/10.3389/fnhum.2014.00884/full |
| work_keys_str_mv | AT annaecraigmcquaide areviewofbraincircuitriesinvolvedinstuttering AT haritheakram areviewofbraincircuitriesinvolvedinstuttering AT ludvicezrinzo areviewofbraincircuitriesinvolvedinstuttering AT elinaetripoliti areviewofbraincircuitriesinvolvedinstuttering AT annaecraigmcquaide reviewofbraincircuitriesinvolvedinstuttering AT haritheakram reviewofbraincircuitriesinvolvedinstuttering AT ludvicezrinzo reviewofbraincircuitriesinvolvedinstuttering AT elinaetripoliti reviewofbraincircuitriesinvolvedinstuttering |