Transglutaminase 2 Expression and Its Prognostic Significance in Clear Cell Renal Cell Carcinoma
Background: A few recent studies have demonstrated a possible role of transglutaminase 2 (TG2) in tumorigenesis or progression of renal cell carcinoma (RCC). The aim of this study was to examine TG2 expression and its clinicopathologic significance in a large number of human clear cell RCCs (CCRCCs)...
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Korean Society of Pathologists & the Korean Society for Cytopathology
2015-01-01
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| Series: | Journal of Pathology and Translational Medicine |
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| Online Access: | http://www.jpatholtm.org/upload/pdf/jptm-49-1-37.pdf |
| _version_ | 1818132956035678208 |
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| author | Min Jee Park Hae Woon Baek Ye-Young Rhee Cheol Lee Jeong Whan Park Hwal Woong Kim Kyung Chul Moon |
| author_facet | Min Jee Park Hae Woon Baek Ye-Young Rhee Cheol Lee Jeong Whan Park Hwal Woong Kim Kyung Chul Moon |
| author_sort | Min Jee Park |
| collection | DOAJ |
| description | Background: A few recent studies have demonstrated a possible role of transglutaminase 2 (TG2) in tumorigenesis or progression of renal cell carcinoma (RCC). The aim of this study was to examine TG2 expression and its clinicopathologic significance in a large number of human clear cell RCCs (CCRCCs). Methods: We analyzed 638 CCRCC patients who underwent partial or radical nephrectomy between 1995 and 2005. The expression of TG2 was determined by immunohistochemistry and categorized into four groups, according to staining intensity: negative (0), mild (1+), moderate (2+), and strong (3+). Results: TG2 staining intensity was negative in 8.5% of CCRCC (n=54), 1+ in 32.6% (n=208), 2+ in 50.5% (n=322), and 3+ in 8.5% (n=54). Strong TG2 expression was correlated with high Fuhrman nuclear grade (p=.011), high T category (p=.049), metastasis (p=.043) and male sex (p<.001) but not with N category.The survival analysis showed a significant association between strong TG2 expression and worse overall and cancer-specific survival (p=.027 and p=.010, respectively). On multivariate analysis, strong TG2 expression was a marginally significant prognostic indicator for Fuhrman nuclear grade and TNM staging (p=.054). Conclusions: Our study is the first to demonstrate the clinicopathologic significance of TG2 expression in a large number of human CCRCC samples. Strong TG2 expression was associated with high nuclear grade and poor prognosis. |
| first_indexed | 2024-12-11T08:45:03Z |
| format | Article |
| id | doaj.art-1979df5c12704b7dbfc43c8740d2257c |
| institution | Directory Open Access Journal |
| issn | 2383-7837 2383-7845 |
| language | English |
| last_indexed | 2024-12-11T08:45:03Z |
| publishDate | 2015-01-01 |
| publisher | Korean Society of Pathologists & the Korean Society for Cytopathology |
| record_format | Article |
| series | Journal of Pathology and Translational Medicine |
| spelling | doaj.art-1979df5c12704b7dbfc43c8740d2257c2022-12-22T01:14:10ZengKorean Society of Pathologists & the Korean Society for CytopathologyJournal of Pathology and Translational Medicine2383-78372383-78452015-01-01491374310.4132/jptm.2014.10.255809Transglutaminase 2 Expression and Its Prognostic Significance in Clear Cell Renal Cell CarcinomaMin Jee Park0Hae Woon Baek1Ye-Young Rhee2Cheol Lee3Jeong Whan Park4Hwal Woong Kim5Kyung Chul Moon6 Department of Pathology, Seoul National University College of Medicine, Seoul, Korea Department of Pathology, Seoul National University College of Medicine, Seoul, Korea Department of Pathology, Seoul National University College of Medicine, Seoul, Korea Department of Pathology, Seoul National University College of Medicine, Seoul, Korea Department of Pathology, Seoul National University College of Medicine, Seoul, Korea Department of Pathology, Good Moonhwa Hospital, Busan, Korea Department of Pathology, Seoul National University College of Medicine, Seoul, KoreaBackground: A few recent studies have demonstrated a possible role of transglutaminase 2 (TG2) in tumorigenesis or progression of renal cell carcinoma (RCC). The aim of this study was to examine TG2 expression and its clinicopathologic significance in a large number of human clear cell RCCs (CCRCCs). Methods: We analyzed 638 CCRCC patients who underwent partial or radical nephrectomy between 1995 and 2005. The expression of TG2 was determined by immunohistochemistry and categorized into four groups, according to staining intensity: negative (0), mild (1+), moderate (2+), and strong (3+). Results: TG2 staining intensity was negative in 8.5% of CCRCC (n=54), 1+ in 32.6% (n=208), 2+ in 50.5% (n=322), and 3+ in 8.5% (n=54). Strong TG2 expression was correlated with high Fuhrman nuclear grade (p=.011), high T category (p=.049), metastasis (p=.043) and male sex (p<.001) but not with N category.The survival analysis showed a significant association between strong TG2 expression and worse overall and cancer-specific survival (p=.027 and p=.010, respectively). On multivariate analysis, strong TG2 expression was a marginally significant prognostic indicator for Fuhrman nuclear grade and TNM staging (p=.054). Conclusions: Our study is the first to demonstrate the clinicopathologic significance of TG2 expression in a large number of human CCRCC samples. Strong TG2 expression was associated with high nuclear grade and poor prognosis.http://www.jpatholtm.org/upload/pdf/jptm-49-1-37.pdfTransglutaminasesCarcinoma, renal cellPrognosis |
| spellingShingle | Min Jee Park Hae Woon Baek Ye-Young Rhee Cheol Lee Jeong Whan Park Hwal Woong Kim Kyung Chul Moon Transglutaminase 2 Expression and Its Prognostic Significance in Clear Cell Renal Cell Carcinoma Journal of Pathology and Translational Medicine Transglutaminases Carcinoma, renal cell Prognosis |
| title | Transglutaminase 2 Expression and Its Prognostic Significance in Clear Cell Renal Cell Carcinoma |
| title_full | Transglutaminase 2 Expression and Its Prognostic Significance in Clear Cell Renal Cell Carcinoma |
| title_fullStr | Transglutaminase 2 Expression and Its Prognostic Significance in Clear Cell Renal Cell Carcinoma |
| title_full_unstemmed | Transglutaminase 2 Expression and Its Prognostic Significance in Clear Cell Renal Cell Carcinoma |
| title_short | Transglutaminase 2 Expression and Its Prognostic Significance in Clear Cell Renal Cell Carcinoma |
| title_sort | transglutaminase 2 expression and its prognostic significance in clear cell renal cell carcinoma |
| topic | Transglutaminases Carcinoma, renal cell Prognosis |
| url | http://www.jpatholtm.org/upload/pdf/jptm-49-1-37.pdf |
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