Identification of Chalcones as Fasciola hepatica Cathepsin L Inhibitors Using a Comprehensive Experimental and Computational Approach.

Identification of Chalcones as Fasciola hepatica Cathepsin L Inhibitors Using a Comprehensive Experimental and Computational Approach.

BACKGROUND:Increased reports of human infections have led fasciolosis, a widespread disease of cattle and sheep caused by the liver flukes Fasciola hepatica and Fasciola gigantica, to be considered an emerging zoonotic disease. Chemotherapy is the main control measure available, and triclabendazole...

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Bibliographic Details
Main Authors: Florencia Ferraro, Alicia Merlino, Nicolás Dell Oca, Jorge Gil, José F Tort, Mercedes Gonzalez, Hugo Cerecetto, Mauricio Cabrera, Ileana Corvo
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-07-01
Series:PLoS Neglected Tropical Diseases
Online Access:http://europepmc.org/articles/PMC4962987?pdf=render

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