Implantable loop recorder in Brugada syndrome: Insights from a single-center experience
Background: This study aimed to investigate the characteristics and outcomes of patients diagnosed with Brugada syndrome (BrS) who underwent implantable loop recorder (ILR) insertion during routine clinical activity. Methods: We conducted a comprehensive screening of all consecutive patients diagnos...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-04-01
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| Series: | International Journal of Cardiology: Heart & Vasculature |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S235290672400037X |
| _version_ | 1827289737017163776 |
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| author | Gianmarco Arabia Manuel Cerini Angelica Cersosimo Paolo Vinciguerra Emiliano Calvi Gianfranco Mitacchione Mohamed Aboelhassan Daniele Giacopelli Antonio Curnis |
| author_facet | Gianmarco Arabia Manuel Cerini Angelica Cersosimo Paolo Vinciguerra Emiliano Calvi Gianfranco Mitacchione Mohamed Aboelhassan Daniele Giacopelli Antonio Curnis |
| author_sort | Gianmarco Arabia |
| collection | DOAJ |
| description | Background: This study aimed to investigate the characteristics and outcomes of patients diagnosed with Brugada syndrome (BrS) who underwent implantable loop recorder (ILR) insertion during routine clinical activity. Methods: We conducted a comprehensive screening of all consecutive patients diagnosed with BrS at our institution. We analyzed baseline clinical characteristics, arrhythmic findings, and outcomes. Results: Out of 147 BrS patients, 42 (29 %) received an ILR, 13 (9 %) underwent implantable cardioverter-defibrillator (ICD) placement, and 92 patients (63 %) continued regular cardiological follow-up. Patients who received an ILR had a higher prevalence of suspected arrhythmic syncope (43 % vs. 22 %, p = 0.012) and tended to be younger (median age 38 years, interquartile range 30–52, vs. 43 years, 35–55, p = 0.044) with a higher presence of SCN5A gene mutations (17 % vs. 6 %, p = 0.066) compared to those who continued regular follow-up. Additionally, compared to patients with an ICD, those with an ILR had a significantly lower frequency of positive programmed ventricular stimulation (0 % vs. 91 %, p < 0.001). During a median follow-up period of 14.7 months (4.7–44.8), no deaths occurred among the patients with ILR. Eight individuals (19 %) were diagnosed with arrhythmic findings through continuous ILR monitoring, primarily atrial fibrillation, and asystolic pauses. The median time from insertion to the occurrence of these events was 8.7 months (3.6–46.4). No adverse events related to ILR were reported. Conclusion: Continuous monitoring with ILR may facilitate the timely detection of non-malignant rhythm disorders in BrS patients with risk factors but without an indication for primary prevention ICD implantation. |
| first_indexed | 2024-03-07T20:04:45Z |
| format | Article |
| id | doaj.art-197d060bb98e4e1b93955bb1e5805186 |
| institution | Directory Open Access Journal |
| issn | 2352-9067 |
| language | English |
| last_indexed | 2024-04-24T11:56:11Z |
| publishDate | 2024-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | International Journal of Cardiology: Heart & Vasculature |
| spelling | doaj.art-197d060bb98e4e1b93955bb1e58051862024-04-09T04:13:16ZengElsevierInternational Journal of Cardiology: Heart & Vasculature2352-90672024-04-0151101371Implantable loop recorder in Brugada syndrome: Insights from a single-center experienceGianmarco Arabia0Manuel Cerini1Angelica Cersosimo2Paolo Vinciguerra3Emiliano Calvi4Gianfranco Mitacchione5Mohamed Aboelhassan6Daniele Giacopelli7Antonio Curnis8Cardiology Department, Spedali Civili Hospital, University of Brescia, Italy; Corresponding author at: Cardiology Department, Spedali Civili Hospital, Piazzale Spedali Civili 1, 25123 Brescia, Italy.Cardiology Department, Spedali Civili Hospital, University of Brescia, ItalyCardiology Department, Spedali Civili Hospital, University of Brescia, ItalyCardiology Department, Spedali Civili Hospital, University of Brescia, ItalyCardiology Department, Spedali Civili Hospital, University of Brescia, ItalyDepartment of Cardiology, Luigi Sacco University Hospital, Milan, ItalyDepartment of Cardiovascular Medicine, Assiut University Heart Hospital, Assiut University, Assiut, EgyptClinical Unit, Biotronik Italia, Cologno Monzese (MI), ItalyCardiology Department, Spedali Civili Hospital, University of Brescia, ItalyBackground: This study aimed to investigate the characteristics and outcomes of patients diagnosed with Brugada syndrome (BrS) who underwent implantable loop recorder (ILR) insertion during routine clinical activity. Methods: We conducted a comprehensive screening of all consecutive patients diagnosed with BrS at our institution. We analyzed baseline clinical characteristics, arrhythmic findings, and outcomes. Results: Out of 147 BrS patients, 42 (29 %) received an ILR, 13 (9 %) underwent implantable cardioverter-defibrillator (ICD) placement, and 92 patients (63 %) continued regular cardiological follow-up. Patients who received an ILR had a higher prevalence of suspected arrhythmic syncope (43 % vs. 22 %, p = 0.012) and tended to be younger (median age 38 years, interquartile range 30–52, vs. 43 years, 35–55, p = 0.044) with a higher presence of SCN5A gene mutations (17 % vs. 6 %, p = 0.066) compared to those who continued regular follow-up. Additionally, compared to patients with an ICD, those with an ILR had a significantly lower frequency of positive programmed ventricular stimulation (0 % vs. 91 %, p < 0.001). During a median follow-up period of 14.7 months (4.7–44.8), no deaths occurred among the patients with ILR. Eight individuals (19 %) were diagnosed with arrhythmic findings through continuous ILR monitoring, primarily atrial fibrillation, and asystolic pauses. The median time from insertion to the occurrence of these events was 8.7 months (3.6–46.4). No adverse events related to ILR were reported. Conclusion: Continuous monitoring with ILR may facilitate the timely detection of non-malignant rhythm disorders in BrS patients with risk factors but without an indication for primary prevention ICD implantation.http://www.sciencedirect.com/science/article/pii/S235290672400037XBrugada syndromeImplantable loop recorderSudden cardiac death |
| spellingShingle | Gianmarco Arabia Manuel Cerini Angelica Cersosimo Paolo Vinciguerra Emiliano Calvi Gianfranco Mitacchione Mohamed Aboelhassan Daniele Giacopelli Antonio Curnis Implantable loop recorder in Brugada syndrome: Insights from a single-center experience International Journal of Cardiology: Heart & Vasculature Brugada syndrome Implantable loop recorder Sudden cardiac death |
| title | Implantable loop recorder in Brugada syndrome: Insights from a single-center experience |
| title_full | Implantable loop recorder in Brugada syndrome: Insights from a single-center experience |
| title_fullStr | Implantable loop recorder in Brugada syndrome: Insights from a single-center experience |
| title_full_unstemmed | Implantable loop recorder in Brugada syndrome: Insights from a single-center experience |
| title_short | Implantable loop recorder in Brugada syndrome: Insights from a single-center experience |
| title_sort | implantable loop recorder in brugada syndrome insights from a single center experience |
| topic | Brugada syndrome Implantable loop recorder Sudden cardiac death |
| url | http://www.sciencedirect.com/science/article/pii/S235290672400037X |
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