Non-canonical Hedgehog signaling regulates spinal cord and muscle regeneration in Xenopus laevis larvae

Non-canonical Hedgehog signaling regulates spinal cord and muscle regeneration in Xenopus laevis larvae

Inducing regeneration in injured spinal cord represents one of modern medicine’s greatest challenges. Research from a variety of model organisms indicates that Hedgehog (Hh) signaling may be a useful target to drive regeneration. However, the mechanisms of Hh signaling-mediated tissue regeneration r...

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Bibliographic Details
Main Authors: Andrew M Hamilton, Olga A Balashova, Laura N Borodinsky
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-05-01
Series:eLife
Subjects:
spinal cord injury
skeletal muscle regeneration
PKA
non-canonical hedgehog signaling
CREB
Gli transcriptional activity
Online Access:https://elifesciences.org/articles/61804

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