Comparison of Effects and Side Effects of Two Naloxone-Based Regimens in Treatment of Methadone Overdose
Background: Acute opioid overdose is a common cause of admission in emergency department. In spite of the fact that naloxone is the main therapy for decades, there are controversies about the proper way of its use. This study aimed to compare two most recommended administration modes for naloxone....
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| Format: | Article |
| Language: | English |
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Arak University of Medical Sciences
2015-11-01
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| Series: | Iranian Journal of Toxicology |
| Subjects: | |
| Online Access: | http://ijt.arakmu.ac.ir/browse.php?a_id=443&sid=1&slc_lang=en |
| _version_ | 1811258156510085120 |
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| author | Arash Yazdanbakhsh Amir Mohammad Kazemifar Kamyar Nazari Bahman Sadeghi Sedeh Hassan Solhi |
| author_facet | Arash Yazdanbakhsh Amir Mohammad Kazemifar Kamyar Nazari Bahman Sadeghi Sedeh Hassan Solhi |
| author_sort | Arash Yazdanbakhsh |
| collection | DOAJ |
| description | Background: Acute opioid overdose is a common cause of admission in emergency department. In spite of the fact that naloxone is the main therapy for decades, there are controversies about the proper way of its use. This study aimed to compare two most recommended administration modes for naloxone.
Methods: In this single-blind clinical trial, 80 patients with methadone overdose syndrome were randomly divided into two equal groups. The patients in infusion group received a constant infusion of naloxone preparation; while in the patients in PRN group, naloxone was administered only if needed clinically. Severity of withdrawal syndrome was evaluated after 30 min, 3 h, and 12 h of the treatments in both groups.
Results: Eighty patients completed the study (10 women and 70 men). Both groups were similar in terms of mean age, sex ratio, and the severity of intoxication. The severity of withdrawal symptom was significantly lower in the PRN group (P<0.001).
Conclusion: Naloxone administration as PRN mode lowers the rate and severity of withdrawal syndrome. It is recommended as the preferred mode of naloxone administration. |
| first_indexed | 2024-04-12T18:08:51Z |
| format | Article |
| id | doaj.art-197ee35fc5894950b545d211960a8f2c |
| institution | Directory Open Access Journal |
| issn | 2008-2967 2251-9459 |
| language | English |
| last_indexed | 2024-04-12T18:08:51Z |
| publishDate | 2015-11-01 |
| publisher | Arak University of Medical Sciences |
| record_format | Article |
| series | Iranian Journal of Toxicology |
| spelling | doaj.art-197ee35fc5894950b545d211960a8f2c2022-12-22T03:21:53ZengArak University of Medical SciencesIranian Journal of Toxicology2008-29672251-94592015-11-011014952Comparison of Effects and Side Effects of Two Naloxone-Based Regimens in Treatment of Methadone OverdoseArash Yazdanbakhsh 0Amir Mohammad Kazemifar 1Kamyar Nazari 2Bahman Sadeghi Sedeh3Hassan Solhi 4Department of Emergency Medicine, Arak University of Medical Science, Arak, Iran.Department of Toxicology, Qazvin University of Medical Science, Qazvin, Iran.MD, Arak University of Medical Science, Arak, Iran.Department of Social Medicine, Arak University of Medical Science, Arak, Iran. * Corresponding Author: E-mail: dr.sadeghis@arakmu.ac.irDepartment of Toxicology, Arak University of Medical Science, Arak, Iran.Background: Acute opioid overdose is a common cause of admission in emergency department. In spite of the fact that naloxone is the main therapy for decades, there are controversies about the proper way of its use. This study aimed to compare two most recommended administration modes for naloxone. Methods: In this single-blind clinical trial, 80 patients with methadone overdose syndrome were randomly divided into two equal groups. The patients in infusion group received a constant infusion of naloxone preparation; while in the patients in PRN group, naloxone was administered only if needed clinically. Severity of withdrawal syndrome was evaluated after 30 min, 3 h, and 12 h of the treatments in both groups. Results: Eighty patients completed the study (10 women and 70 men). Both groups were similar in terms of mean age, sex ratio, and the severity of intoxication. The severity of withdrawal symptom was significantly lower in the PRN group (P<0.001). Conclusion: Naloxone administration as PRN mode lowers the rate and severity of withdrawal syndrome. It is recommended as the preferred mode of naloxone administration.http://ijt.arakmu.ac.ir/browse.php?a_id=443&sid=1&slc_lang=enInfusionMethadone IntoxicationNaloxonePRNWithdrawal syndrome. |
| spellingShingle | Arash Yazdanbakhsh Amir Mohammad Kazemifar Kamyar Nazari Bahman Sadeghi Sedeh Hassan Solhi Comparison of Effects and Side Effects of Two Naloxone-Based Regimens in Treatment of Methadone Overdose Iranian Journal of Toxicology Infusion Methadone Intoxication Naloxone PRN Withdrawal syndrome. |
| title | Comparison of Effects and Side Effects of Two Naloxone-Based Regimens in Treatment of Methadone Overdose |
| title_full | Comparison of Effects and Side Effects of Two Naloxone-Based Regimens in Treatment of Methadone Overdose |
| title_fullStr | Comparison of Effects and Side Effects of Two Naloxone-Based Regimens in Treatment of Methadone Overdose |
| title_full_unstemmed | Comparison of Effects and Side Effects of Two Naloxone-Based Regimens in Treatment of Methadone Overdose |
| title_short | Comparison of Effects and Side Effects of Two Naloxone-Based Regimens in Treatment of Methadone Overdose |
| title_sort | comparison of effects and side effects of two naloxone based regimens in treatment of methadone overdose |
| topic | Infusion Methadone Intoxication Naloxone PRN Withdrawal syndrome. |
| url | http://ijt.arakmu.ac.ir/browse.php?a_id=443&sid=1&slc_lang=en |
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