Integrative Metabolomics, Proteomics and Transcriptomics Analysis Reveals Liver Toxicity of Mesoporous Silica Nanoparticles

Integrative Metabolomics, Proteomics and Transcriptomics Analysis Reveals Liver Toxicity of Mesoporous Silica Nanoparticles

As pharmaceutical excipients, mesoporous silica nanoparticles (MSNs) have attracted considerable concern based on potential risks to the public. The impact of MSNs on biochemical metabolism is poorly understood, and few studies have compared the effects of MSNs administered via different routes. To...

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Bibliographic Details
Main Authors: Jing Li, Runbin Sun, Hui Xu, Guangji Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-01-01
Series:Frontiers in Pharmacology
Subjects:
mesoporous silica nanoparticle
metabolomics
proteomics
transcriptomic
hepatotoxicity
oxidative stress
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.835359/full

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