Validity and Prognostic Value of a Polygenic Risk Score for Parkinson’s Disease

Validity and Prognostic Value of a Polygenic Risk Score for Parkinson’s Disease

Idiopathic Parkinson’s disease (PD) is a complex multifactorial disorder caused by the interplay of both genetic and non-genetic risk factors. Polygenic risk scores (PRSs) are one way to aggregate the effects of a large number of genetic variants upon the risk for a disease like PD in a single quant...

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Bibliographic Details
Main Authors: Sebastian Koch, Björn-Hergen Laabs, Meike Kasten, Eva-Juliane Vollstedt, Jos Becktepe, Norbert Brüggemann, Andre Franke, Ulrike M. Krämer, Gregor Kuhlenbäumer, Wolfgang Lieb, Brit Mollenhauer, Miriam Neis, Claudia Trenkwalder, Eva Schäffer, Tatiana Usnich, Michael Wittig, Christine Klein, Inke R. König, Katja Lohmann, Michael Krawczak, Amke Caliebe
Format: Article
Language:English
Published: MDPI AG 2021-11-01
Series:Genes
Subjects:
Parkinson’s disease
polygenic risk score
replication
validation
prognostic value
genetic risk
Online Access:https://www.mdpi.com/2073-4425/12/12/1859

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