O3 Impact of hyperglycaemia and the therapeutic action of metformin on the length of the telomers
Introduction: Hyperglycemia is one of the most important factors that determine the production of oxidative stress and inflammation, processes that can accelerate telomere shortening. Objectives: The objectives were to analyse the absolute telomere length (aTL) in individuals with altered fasting g...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | Spanish |
| Published: |
Sello Editorial Lugones
2020-11-01
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| Series: | Revista de la Sociedad Argentina de Diabetes |
| Subjects: | |
| Online Access: | https://revistasad.com/index.php/diabetes/article/view/364 |
| Summary: | Introduction: Hyperglycemia is one of the most important factors that determine the production of oxidative stress and inflammation, processes that can accelerate telomere shortening.
Objectives: The objectives were to analyse the absolute telomere length (aTL) in individuals with altered fasting glucose levels (AFG) compared to individuals with normal glucose levels (NFG). To study from a prospective controlled study, the variation in aTL in patients with decompensated type 2 diabetes (T2D) before and after treatment.
Materials and Methods: A population of 246 individuals of both genders was studied, which were divided into a group of individuals with blood glucose levels <110 mg / dl (NFG group, made up only of healthy individuals) and blood glucose levels ≥110 mg / dl and <125 mg / dl (AFG group, made up of individuals with obesity, individuals with T2D or MODY). In addition, each group was divided by age groups: under 25 years (<25Y), between 25 and 50 years (25-50Y) and over 50 years (> 50Y). A subgroup of 30 patients with newly diagnosed T2D was studied, at the beginning (T0), and at 6 months (T6) of a pharmacological treatment and hygienic-dietary measures with the objective of achieving metabolic compensation. In both studies, the biochemical-clinical variables of all individuals and the aTL were determined by quantitative real-time PCR. Statistical analyses were performed using Graph Pad Prism and SPSS software. |
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| ISSN: | 0325-5247 2346-9420 |