Biological Impact of Gold Nanoparticle on Estradaiol and Testosterone Levels in Sera of Human Males
Background: There is a little information on the potential nanoparticle risk to human health, particularly on the sex hormones. Objectives: the present study aims to investigate the impact of gold nanoparticles potential toxicity on the levels of sex hormones testosterone (T) and estradiol (E2) in s...
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| Format: | Article |
| Language: | English |
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College of Medicine University of Baghdad
2016-01-01
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| Series: | مجلة كلية الطب |
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| Online Access: | http://iqjmc.uobaghdad.edu.iq/index.php/19JFacMedBaghdad36/article/view/403 |
| _version_ | 1797368635068514304 |
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| author | Sura A. Abdulsattar |
| author_facet | Sura A. Abdulsattar |
| author_sort | Sura A. Abdulsattar |
| collection | DOAJ |
| description | Background: There is a little information on the potential nanoparticle risk to human health, particularly on the sex hormones.
Objectives: the present study aims to investigate the impact of gold nanoparticles potential toxicity on the levels of sex hormones testosterone (T) and estradiol (E2) in sera of human males
Patients and methods: a total of 25 healthy men volunteers aged (20-45) years participated. Four types of gold nanoparticles were used to study their impact on estradiol and testosterone levels.
Results: The results indicated inhibiting effect of gold nanoparticles on E2 level and activating effect on T level .The low impact of T/E2 by gold nanoparticles was executed at 20μl serum.
Conclusion: different types of gold nanoparticles have an impact on sex hormone binding to their receptors and thus effect on its level in the blood, hence affects the biological processes that are dependant on hormone concentration. |
| first_indexed | 2024-03-08T17:35:35Z |
| format | Article |
| id | doaj.art-19806060703d4e44b36669995b2494a4 |
| institution | Directory Open Access Journal |
| issn | 0041-9419 2410-8057 |
| language | English |
| last_indexed | 2024-03-08T17:35:35Z |
| publishDate | 2016-01-01 |
| publisher | College of Medicine University of Baghdad |
| record_format | Article |
| series | مجلة كلية الطب |
| spelling | doaj.art-19806060703d4e44b36669995b2494a42024-01-02T12:51:14ZengCollege of Medicine University of Baghdadمجلة كلية الطب0041-94192410-80572016-01-0157410.32007/med.1936/jfacmedbagdad.v57i4.17Biological Impact of Gold Nanoparticle on Estradaiol and Testosterone Levels in Sera of Human MalesSura A. Abdulsattar0Dept. of Chemistry /College of Science /Al-Mustansyria University, Iraq.Background: There is a little information on the potential nanoparticle risk to human health, particularly on the sex hormones. Objectives: the present study aims to investigate the impact of gold nanoparticles potential toxicity on the levels of sex hormones testosterone (T) and estradiol (E2) in sera of human males Patients and methods: a total of 25 healthy men volunteers aged (20-45) years participated. Four types of gold nanoparticles were used to study their impact on estradiol and testosterone levels. Results: The results indicated inhibiting effect of gold nanoparticles on E2 level and activating effect on T level .The low impact of T/E2 by gold nanoparticles was executed at 20μl serum. Conclusion: different types of gold nanoparticles have an impact on sex hormone binding to their receptors and thus effect on its level in the blood, hence affects the biological processes that are dependant on hormone concentration.http://iqjmc.uobaghdad.edu.iq/index.php/19JFacMedBaghdad36/article/view/403estradiol, testosterone, nanoparticle, gold, hormone. |
| spellingShingle | Sura A. Abdulsattar Biological Impact of Gold Nanoparticle on Estradaiol and Testosterone Levels in Sera of Human Males مجلة كلية الطب estradiol, testosterone, nanoparticle, gold, hormone. |
| title | Biological Impact of Gold Nanoparticle on Estradaiol and Testosterone Levels in Sera of Human Males |
| title_full | Biological Impact of Gold Nanoparticle on Estradaiol and Testosterone Levels in Sera of Human Males |
| title_fullStr | Biological Impact of Gold Nanoparticle on Estradaiol and Testosterone Levels in Sera of Human Males |
| title_full_unstemmed | Biological Impact of Gold Nanoparticle on Estradaiol and Testosterone Levels in Sera of Human Males |
| title_short | Biological Impact of Gold Nanoparticle on Estradaiol and Testosterone Levels in Sera of Human Males |
| title_sort | biological impact of gold nanoparticle on estradaiol and testosterone levels in sera of human males |
| topic | estradiol, testosterone, nanoparticle, gold, hormone. |
| url | http://iqjmc.uobaghdad.edu.iq/index.php/19JFacMedBaghdad36/article/view/403 |
| work_keys_str_mv | AT suraaabdulsattar biologicalimpactofgoldnanoparticleonestradaiolandtestosteronelevelsinseraofhumanmales |