Human cystic echinococcosis in South Africa
Cystic echinococcosis (CE) is caused by the tapeworm, Echinococcus granulosus. The tapeworms resides in the small intestines of canids and the lifecycle involves both intermediate and definitive hosts. Humans are accidental intermediate hosts. Cystic echinococcosis is an economically important infe...
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| Format: | Article |
| Language: | English |
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AOSIS
2012-06-01
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| Series: | Onderstepoort Journal of Veterinary Research |
| Subjects: | |
| Online Access: | https://ojvr.org/index.php/ojvr/article/view/469 |
| _version_ | 1819083500184141824 |
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| author | Benjamin Mogoye Colin N. Menezes Martin P. Grobusch Kerstin Wahlers John Frean |
| author_facet | Benjamin Mogoye Colin N. Menezes Martin P. Grobusch Kerstin Wahlers John Frean |
| author_sort | Benjamin Mogoye |
| collection | DOAJ |
| description | Cystic echinococcosis (CE) is caused by the tapeworm, Echinococcus granulosus. The tapeworms resides in the small intestines of canids and the lifecycle involves both intermediate and definitive hosts. Humans are accidental intermediate hosts. Cystic echinococcosis is an economically important infection constituting a threat to public health, and is considered an emerging disease around the world. There are at least 10 Echinococcus strain types (G1 – G10), each exhibiting diversity of morphology, development and host range. The epidemiology of CE is poorly understood in South Africa. A retrospective data analysis of the National Health Laboratory Service (NHLS) laboratory information system on echinococcosis serology, microscopy and histopathology results in eight provinces (excluding KwaZula-Natal) showed an overall positivity rate in submitted diagnostic samples of 17.0% (1056/6211), with the Eastern Cape (30.4%), North West (19.0%) and Northern Cape (18.0%) provinces showing highest rates. The data showed considerable variability between provinces. The review also showed that most proven cases were negative on serology, implying that the actual number of patients could be underestimated. To our knowledge, no data exist about the prevalent strains of E. granulosus and this prospective study will attempt to fill that gap. The aim is to genotype strains causing the disease in South Africa. Two different polymerase chain reaction (PCR) methods will be used to respectively target the 12S rRNA and nad 1 genes. To date, three samples have been genotyped as G1, G5 and G6; suggesting diversity of strains prevalent in the country, but more data is needed for a clearer picture. |
| first_indexed | 2024-12-21T20:33:33Z |
| format | Article |
| id | doaj.art-19818a4a303b4847ad526598030609de |
| institution | Directory Open Access Journal |
| issn | 0030-2465 2219-0635 |
| language | English |
| last_indexed | 2024-12-21T20:33:33Z |
| publishDate | 2012-06-01 |
| publisher | AOSIS |
| record_format | Article |
| series | Onderstepoort Journal of Veterinary Research |
| spelling | doaj.art-19818a4a303b4847ad526598030609de2022-12-21T18:51:10ZengAOSISOnderstepoort Journal of Veterinary Research0030-24652219-06352012-06-0179210.4102/ojvr.v79i2.469346Human cystic echinococcosis in South AfricaBenjamin Mogoye0Colin N. Menezes1Martin P. Grobusch2Kerstin Wahlers3John Frean4National Institute for Communicable Diseases, National Health Laboratory ServiceDepartment of Internal Medicine, Chris Hani Baragwanath Hospital and University of the WitwatersrandDepartment of Internal Medicine, Chris Hani Baragwanath Hospital and University of the WitwatersrandComprehensive Infectious Diseases Center, University HospitalsNational Institute for Communicable Diseases, National Health Laboratory ServiceCystic echinococcosis (CE) is caused by the tapeworm, Echinococcus granulosus. The tapeworms resides in the small intestines of canids and the lifecycle involves both intermediate and definitive hosts. Humans are accidental intermediate hosts. Cystic echinococcosis is an economically important infection constituting a threat to public health, and is considered an emerging disease around the world. There are at least 10 Echinococcus strain types (G1 – G10), each exhibiting diversity of morphology, development and host range. The epidemiology of CE is poorly understood in South Africa. A retrospective data analysis of the National Health Laboratory Service (NHLS) laboratory information system on echinococcosis serology, microscopy and histopathology results in eight provinces (excluding KwaZula-Natal) showed an overall positivity rate in submitted diagnostic samples of 17.0% (1056/6211), with the Eastern Cape (30.4%), North West (19.0%) and Northern Cape (18.0%) provinces showing highest rates. The data showed considerable variability between provinces. The review also showed that most proven cases were negative on serology, implying that the actual number of patients could be underestimated. To our knowledge, no data exist about the prevalent strains of E. granulosus and this prospective study will attempt to fill that gap. The aim is to genotype strains causing the disease in South Africa. Two different polymerase chain reaction (PCR) methods will be used to respectively target the 12S rRNA and nad 1 genes. To date, three samples have been genotyped as G1, G5 and G6; suggesting diversity of strains prevalent in the country, but more data is needed for a clearer picture.https://ojvr.org/index.php/ojvr/article/view/469Echinococcus granulosussurveyprovincesSouth Africa |
| spellingShingle | Benjamin Mogoye Colin N. Menezes Martin P. Grobusch Kerstin Wahlers John Frean Human cystic echinococcosis in South Africa Onderstepoort Journal of Veterinary Research Echinococcus granulosus survey provinces South Africa |
| title | Human cystic echinococcosis in South Africa |
| title_full | Human cystic echinococcosis in South Africa |
| title_fullStr | Human cystic echinococcosis in South Africa |
| title_full_unstemmed | Human cystic echinococcosis in South Africa |
| title_short | Human cystic echinococcosis in South Africa |
| title_sort | human cystic echinococcosis in south africa |
| topic | Echinococcus granulosus survey provinces South Africa |
| url | https://ojvr.org/index.php/ojvr/article/view/469 |
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