The age-related pattern of inner retinal thickening is affected by myopia development and progression
Abstract The longitudinal effect of myopic eye growth on each individual retinal layer has not been described to date on an established non-human primate (NHP) model of myopia. We evaluated the changes experienced by the overall and individual central and mid-peripheral retinal thickness profiles in...
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| Format: | Article |
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Nature Portfolio
2022-12-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-26598-w |
| _version_ | 1797977453277216768 |
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| author | Reynolds Kwame Ablordeppey Carol Lin Alexandra Benavente-Perez |
| author_facet | Reynolds Kwame Ablordeppey Carol Lin Alexandra Benavente-Perez |
| author_sort | Reynolds Kwame Ablordeppey |
| collection | DOAJ |
| description | Abstract The longitudinal effect of myopic eye growth on each individual retinal layer has not been described to date on an established non-human primate (NHP) model of myopia. We evaluated the changes experienced by the overall and individual central and mid-peripheral retinal thickness profiles in marmosets (Callithrix jacchus) induced with myopia continuously for 5.5 months compared to controls using spectral-domain optical coherence tomography. Cycloplegic refractive state (Rx), vitreous chamber depth (VCD) and retinal thickness were measured at baseline and after 3 and 5.5 months on thirteen marmosets: eight animals with lens-induced myopia and five untreated controls. The overall and individual retinal layer thickness in the central and mid-peripheral retina were obtained and compared between groups. Regression models were used to explore the extent to which VCD or Rx changes could predict the thickness changes observed. While the retinas of control marmosets thickened significantly over 5.5 months, marmosets with lens-induced myopia experienced less retinal thickening and thinning at times, mostly in the inner neuroretinal layers and the ganglion cell-inner plexiform layer. The regression models suggest that 90% of the growth and refractive changes observed could be predicted by the thickness changes in the near to mid peripheral retina. This study confirms the longitudinal effect that myopia has on the inner retina of a NHP model during the early stages of myopia development. The observed myopia-driven differences in inner retina thickness templates might represent early biomarkers of myopia progression and associated complications. |
| first_indexed | 2024-04-11T05:07:08Z |
| format | Article |
| id | doaj.art-19825f644a1349539e215aa245a61029 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-11T05:07:08Z |
| publishDate | 2022-12-01 |
| publisher | Nature Portfolio |
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| series | Scientific Reports |
| spelling | doaj.art-19825f644a1349539e215aa245a610292022-12-25T12:15:20ZengNature PortfolioScientific Reports2045-23222022-12-0112111310.1038/s41598-022-26598-wThe age-related pattern of inner retinal thickening is affected by myopia development and progressionReynolds Kwame Ablordeppey0Carol Lin1Alexandra Benavente-Perez2Department of Biological and Vision Sciences, College of Optometry, State University of New YorkDepartment of Biological and Vision Sciences, College of Optometry, State University of New YorkDepartment of Biological and Vision Sciences, College of Optometry, State University of New YorkAbstract The longitudinal effect of myopic eye growth on each individual retinal layer has not been described to date on an established non-human primate (NHP) model of myopia. We evaluated the changes experienced by the overall and individual central and mid-peripheral retinal thickness profiles in marmosets (Callithrix jacchus) induced with myopia continuously for 5.5 months compared to controls using spectral-domain optical coherence tomography. Cycloplegic refractive state (Rx), vitreous chamber depth (VCD) and retinal thickness were measured at baseline and after 3 and 5.5 months on thirteen marmosets: eight animals with lens-induced myopia and five untreated controls. The overall and individual retinal layer thickness in the central and mid-peripheral retina were obtained and compared between groups. Regression models were used to explore the extent to which VCD or Rx changes could predict the thickness changes observed. While the retinas of control marmosets thickened significantly over 5.5 months, marmosets with lens-induced myopia experienced less retinal thickening and thinning at times, mostly in the inner neuroretinal layers and the ganglion cell-inner plexiform layer. The regression models suggest that 90% of the growth and refractive changes observed could be predicted by the thickness changes in the near to mid peripheral retina. This study confirms the longitudinal effect that myopia has on the inner retina of a NHP model during the early stages of myopia development. The observed myopia-driven differences in inner retina thickness templates might represent early biomarkers of myopia progression and associated complications.https://doi.org/10.1038/s41598-022-26598-w |
| spellingShingle | Reynolds Kwame Ablordeppey Carol Lin Alexandra Benavente-Perez The age-related pattern of inner retinal thickening is affected by myopia development and progression Scientific Reports |
| title | The age-related pattern of inner retinal thickening is affected by myopia development and progression |
| title_full | The age-related pattern of inner retinal thickening is affected by myopia development and progression |
| title_fullStr | The age-related pattern of inner retinal thickening is affected by myopia development and progression |
| title_full_unstemmed | The age-related pattern of inner retinal thickening is affected by myopia development and progression |
| title_short | The age-related pattern of inner retinal thickening is affected by myopia development and progression |
| title_sort | age related pattern of inner retinal thickening is affected by myopia development and progression |
| url | https://doi.org/10.1038/s41598-022-26598-w |
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