Impact of anterior cruciate ligament surgery on the development of knee osteoarthritis: A systematic literature review and meta-analysis comparing non-surgical and surgical treatments
Introduction: Context: The development of knee osteoarthritis (OA) after anterior cruciate ligament (ACL) injury is now widely recognized. The impact of surgical or non-surgical management on the development of post-traumatic osteoarthritis is still debated in the medical community.Here, we present...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-09-01
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| Series: | Osteoarthritis and Cartilage Open |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S266591312300033X |
| _version_ | 1797732840293531648 |
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| author | Stephanie Ferrero Marion Louvois Thomas Barnetche Veronique Breuil Christian Roux |
| author_facet | Stephanie Ferrero Marion Louvois Thomas Barnetche Veronique Breuil Christian Roux |
| author_sort | Stephanie Ferrero |
| collection | DOAJ |
| description | Introduction: Context: The development of knee osteoarthritis (OA) after anterior cruciate ligament (ACL) injury is now widely recognized. The impact of surgical or non-surgical management on the development of post-traumatic osteoarthritis is still debated in the medical community.Here, we present a meta-analysis comparing the impact of surgical or non-surgical management of ACL injuries on the development of knee OA. Method: A systematic literature review was conducted using data from the PubMed, EMBASE, Medline, and Cochrane libraries from February to May 2019. Only randomized clinical trials published between 2005 and 2019 with a non-surgical group and a surgical group were included to explore the onset or progression of knee OA after ACL injury. Trials had to have at least one radiographic endpoint (Kellgren—Lawrence scoring system). Heterogeneity was assessed using the Cochrane's Q and I2 statistical methods. Results: Only three randomized controlled trials met the inclusion criteria and were selected for meta-analysis. Of the 343 injured knees included in the studies, 180 underwent ACL reconstruction and 163 underwent non-surgical treatment. The relative risk of knee osteoarthritis was higher after surgery than after non-surgical treatment (RR 1.72, CI 95% [1.18–2.53], I2 = 0%). Conclusion: The results of this meta-analysis suggest a predisposition to knee osteoarthritis after ACL reconstruction surgery compared with non-surgical management. Due to the small number of good quality studies available, further well-conducted randomised studies are needed to confirm these findings. |
| first_indexed | 2024-03-12T12:19:22Z |
| format | Article |
| id | doaj.art-198294a7299f4c09bdfe8805ef9c8918 |
| institution | Directory Open Access Journal |
| issn | 2665-9131 |
| language | English |
| last_indexed | 2024-03-12T12:19:22Z |
| publishDate | 2023-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Osteoarthritis and Cartilage Open |
| spelling | doaj.art-198294a7299f4c09bdfe8805ef9c89182023-08-30T05:54:46ZengElsevierOsteoarthritis and Cartilage Open2665-91312023-09-0153100366Impact of anterior cruciate ligament surgery on the development of knee osteoarthritis: A systematic literature review and meta-analysis comparing non-surgical and surgical treatmentsStephanie Ferrero0Marion Louvois1Thomas Barnetche2Veronique Breuil3Christian Roux4Department of Rheumatology, Pasteur Hospital, Nice University Hospital, Nice Sophia Antipolis University, F-06000, Nice, France; Corresponding author.Department of Rheumatology, Pasteur Hospital, Nice University Hospital, Nice Sophia Antipolis University, F-06000, Nice, FranceDepartment of Rheumatology, University Hospital of Bordeaux Pellegrin, FranceDepartment of Rheumatology, Pasteur Hospital, Nice University Hospital, Nice Sophia Antipolis University, F-06000, Nice, FranceDepartment Rheumatology, University of Cote D'Azur, Nice Hospital, Laboratory LAMHESS, EA6312, IBV CNRS IMR 7277 INSERM U1091 UNS, FranceIntroduction: Context: The development of knee osteoarthritis (OA) after anterior cruciate ligament (ACL) injury is now widely recognized. The impact of surgical or non-surgical management on the development of post-traumatic osteoarthritis is still debated in the medical community.Here, we present a meta-analysis comparing the impact of surgical or non-surgical management of ACL injuries on the development of knee OA. Method: A systematic literature review was conducted using data from the PubMed, EMBASE, Medline, and Cochrane libraries from February to May 2019. Only randomized clinical trials published between 2005 and 2019 with a non-surgical group and a surgical group were included to explore the onset or progression of knee OA after ACL injury. Trials had to have at least one radiographic endpoint (Kellgren—Lawrence scoring system). Heterogeneity was assessed using the Cochrane's Q and I2 statistical methods. Results: Only three randomized controlled trials met the inclusion criteria and were selected for meta-analysis. Of the 343 injured knees included in the studies, 180 underwent ACL reconstruction and 163 underwent non-surgical treatment. The relative risk of knee osteoarthritis was higher after surgery than after non-surgical treatment (RR 1.72, CI 95% [1.18–2.53], I2 = 0%). Conclusion: The results of this meta-analysis suggest a predisposition to knee osteoarthritis after ACL reconstruction surgery compared with non-surgical management. Due to the small number of good quality studies available, further well-conducted randomised studies are needed to confirm these findings.http://www.sciencedirect.com/science/article/pii/S266591312300033XKneeOsteoarthritisAnterior cruciate ligamentInjuryRadiographic |
| spellingShingle | Stephanie Ferrero Marion Louvois Thomas Barnetche Veronique Breuil Christian Roux Impact of anterior cruciate ligament surgery on the development of knee osteoarthritis: A systematic literature review and meta-analysis comparing non-surgical and surgical treatments Osteoarthritis and Cartilage Open Knee Osteoarthritis Anterior cruciate ligament Injury Radiographic |
| title | Impact of anterior cruciate ligament surgery on the development of knee osteoarthritis: A systematic literature review and meta-analysis comparing non-surgical and surgical treatments |
| title_full | Impact of anterior cruciate ligament surgery on the development of knee osteoarthritis: A systematic literature review and meta-analysis comparing non-surgical and surgical treatments |
| title_fullStr | Impact of anterior cruciate ligament surgery on the development of knee osteoarthritis: A systematic literature review and meta-analysis comparing non-surgical and surgical treatments |
| title_full_unstemmed | Impact of anterior cruciate ligament surgery on the development of knee osteoarthritis: A systematic literature review and meta-analysis comparing non-surgical and surgical treatments |
| title_short | Impact of anterior cruciate ligament surgery on the development of knee osteoarthritis: A systematic literature review and meta-analysis comparing non-surgical and surgical treatments |
| title_sort | impact of anterior cruciate ligament surgery on the development of knee osteoarthritis a systematic literature review and meta analysis comparing non surgical and surgical treatments |
| topic | Knee Osteoarthritis Anterior cruciate ligament Injury Radiographic |
| url | http://www.sciencedirect.com/science/article/pii/S266591312300033X |
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