Fractional-Order Models for Biochemical Processes

Biochemical processes present complex mechanisms and can be described by various computational models. Complex systems present a variety of problems, especially the loss of intuitive understanding. The present work uses fractional-order calculus to obtain mathematical models for erythritol and manni...

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Main Authors: Eva-H. Dulf, Dan C. Vodnar, Alex Danku, Cristina-I. Muresan, Ovidiu Crisan
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:Fractal and Fractional
Subjects:
Online Access:https://www.mdpi.com/2504-3110/4/2/12
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author Eva-H. Dulf
Dan C. Vodnar
Alex Danku
Cristina-I. Muresan
Ovidiu Crisan
author_facet Eva-H. Dulf
Dan C. Vodnar
Alex Danku
Cristina-I. Muresan
Ovidiu Crisan
author_sort Eva-H. Dulf
collection DOAJ
description Biochemical processes present complex mechanisms and can be described by various computational models. Complex systems present a variety of problems, especially the loss of intuitive understanding. The present work uses fractional-order calculus to obtain mathematical models for erythritol and mannitol synthesis. The obtained models are useful for both prediction and process optimization. The models present the complex behavior of the process due to the fractional order, without losing the physical meaning of gain and time constants. To validate each obtained model, the simulation results were compared with experimental data. In order to highlight the advantages of fractional-order models, comparisons with the corresponding integer-order models are presented.
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spelling doaj.art-198326c8dee449bd94815e1fb42fb8092023-11-19T21:14:28ZengMDPI AGFractal and Fractional2504-31102020-04-01421210.3390/fractalfract4020012Fractional-Order Models for Biochemical ProcessesEva-H. Dulf0Dan C. Vodnar1Alex Danku2Cristina-I. Muresan3Ovidiu Crisan4Faculty of Automation and Computer Science, Technical University of Cluj-Napoca, 400144 Cluj-Napoca, RomaniaFood Science and Technology Department, University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca, 400372 Cluj-Napoca, RomaniaFaculty of Automation and Computer Science, Technical University of Cluj-Napoca, 400144 Cluj-Napoca, RomaniaFaculty of Automation and Computer Science, Technical University of Cluj-Napoca, 400144 Cluj-Napoca, RomaniaDepartment of Organic Chemistry, Iuliu Hațieganu University of Medicine and Pharmacy, 400012 Cluj-Napoca, RomaniaBiochemical processes present complex mechanisms and can be described by various computational models. Complex systems present a variety of problems, especially the loss of intuitive understanding. The present work uses fractional-order calculus to obtain mathematical models for erythritol and mannitol synthesis. The obtained models are useful for both prediction and process optimization. The models present the complex behavior of the process due to the fractional order, without losing the physical meaning of gain and time constants. To validate each obtained model, the simulation results were compared with experimental data. In order to highlight the advantages of fractional-order models, comparisons with the corresponding integer-order models are presented.https://www.mdpi.com/2504-3110/4/2/12biochemical processfractional order modeloptimization
spellingShingle Eva-H. Dulf
Dan C. Vodnar
Alex Danku
Cristina-I. Muresan
Ovidiu Crisan
Fractional-Order Models for Biochemical Processes
Fractal and Fractional
biochemical process
fractional order model
optimization
title Fractional-Order Models for Biochemical Processes
title_full Fractional-Order Models for Biochemical Processes
title_fullStr Fractional-Order Models for Biochemical Processes
title_full_unstemmed Fractional-Order Models for Biochemical Processes
title_short Fractional-Order Models for Biochemical Processes
title_sort fractional order models for biochemical processes
topic biochemical process
fractional order model
optimization
url https://www.mdpi.com/2504-3110/4/2/12
work_keys_str_mv AT evahdulf fractionalordermodelsforbiochemicalprocesses
AT dancvodnar fractionalordermodelsforbiochemicalprocesses
AT alexdanku fractionalordermodelsforbiochemicalprocesses
AT cristinaimuresan fractionalordermodelsforbiochemicalprocesses
AT ovidiucrisan fractionalordermodelsforbiochemicalprocesses